Promoting College Match for Low-Income Students: Lessons for Practitioners

Most high school reform efforts understandably focus on boosting the success of low-income students who are underachieving academically, but in every school district where students struggle, there are academically capable low-income and minority students who do graduate prepared for college. Yet each year, many of these students choose to attend nonselective four-year colleges where graduation rates are distressingly low. Others enroll at two-year colleges, where degree completion and transfer rates are even lower. Many more do not attend college at all. In 2010, MDRC and its partners pilot-tested an innovative advising program, College Match, in three Chicago public high schools. This practitioner brief presents practical lessons from that program. It offers five strategies that show promise, that could be widely applicable, that counselors and advisers can integrate into their existing college guidance activities, and that can be implemented in college advising settings in and out of schools

In Search of a Match: A Guide for Helping Students Make Informed College Choices

This guide is designed for counselors, teachers, and advisers who work with high school students from low-income families and students who are the first in their families to pursue a college education. It offers strategies for helping these students identify, consider, and enroll in "match" colleges -- that is, selective colleges that are a good fit for students based on their academic profiles, financial considerations, and personal needs. Many of the suggestions in this guide are based on insights and lessons learned from the College Match Program, a pilot program that MDRC codeveloped with several partners and implemented in Chicago and New York City to address the problem of "undermatching," or what happens when capable high school students enroll in colleges for which they are academically overqualified or do not apply to college at all. The key lessons of the College Match Program, which are reflected in this guide, are that students are willing to apply to selective colleges when:* They learn about the range of options available to them.* They engage in the planning process early enough to meet college and financial aid deadlines.* They receive guidance, support, and encouragement at all stages.Informed by those key lessons, the guide tracks the many steps in the college search, application, and selection process, suggesting ways to incorporate a match focus at each stage: creating a match culture, identifying match colleges, applying to match colleges, assessing the costs of various college options, selecting a college, and enrolling in college. Because many students question their ability to succeed academically or fit in socially at a selective college, and because they may hesitate to enroll even when they receive good advice and encouragement, the guide offers tips and strategies to help students build the confidence they need to pursue the best college education available to them. Each section also suggests tools and resources in the form of websites and printed materials that counselors, advisers, and students can use, as well as case studies to illustrate the experiences of College Match participants throughout the process

Brucella abortus Infection of Placental Trophoblasts Triggers Endoplasmic Reticulum Stress-Mediated Cell Death and Fetal Loss via Type IV Secretion System-Dependent Activation of CHOP.

Subversion of endoplasmic reticulum (ER) function is a feature shared by multiple intracellular bacteria and viruses, and in many cases this disruption of cellular function activates pathways of the unfolded protein response (UPR). In the case of infection with Brucella abortus, the etiologic agent of brucellosis, the unfolded protein response in the infected placenta contributes to placentitis and abortion, leading to pathogen transmission. Here we show that B. abortus infection of pregnant mice led to death of infected placental trophoblasts in a manner that depended on the VirB type IV secretion system (T4SS) and its effector VceC. The trophoblast death program required the ER stress-induced transcription factor CHOP. While NOD1/NOD2 expression in macrophages contributed to ER stress-induced inflammation, these receptors did not play a role in trophoblast death. Both placentitis and abortion were independent of apoptosis-associated Speck-like protein containing a caspase activation and recruitment domain (ASC). These studies show that B. abortus uses its T4SS to induce cell-type-specific responses to ER stress in trophoblasts that trigger placental inflammation and abortion. Our results suggest further that in B. abortus the T4SS and its effectors are under selection as bacterial transmission factors.IMPORTANCE Brucella abortus infects the placenta of pregnant cows, where it replicates to high levels and triggers abortion of the calf. The aborted material is highly infectious and transmits infection to both cows and humans, but very little is known about how B. abortus causes abortion. By studying this infection in pregnant mice, we discovered that B. abortus kills trophoblasts, which are important cells for maintaining pregnancy. This killing required an injected bacterial protein (VceC) that triggered an endoplasmic reticulum (ER) stress response in the trophoblast. By inhibiting ER stress or infecting mice that lack CHOP, a protein induced by ER stress, we could prevent death of trophoblasts, reduce inflammation, and increase the viability of the pups. Our results suggest that B. abortus injects VceC into placental trophoblasts to promote its transmission by abortion

Bringing Developmental Education to Scale: Lessons from the Developmental Education Initiative

While over half of all community college students are judged to need developmental (or remedial) reading, composition, and/or mathematics classes, these courses — which students are often required to complete before they can enroll in courses that confer credit toward a degree — typically present major roadblocks to student progress. To address this issue, the Developmental Education Initiative (DEI) was created in 2009. Fifteen highly diverse community colleges that had been early participants in Achieving the Dream, a national community college reform network, each received a three-year grant of $743,000 to scale up existing interventions or establish new ones that would help students progress through developmental courses more quickly and successfully. The colleges typically identified two or three “focal strategies” — most often, student support services and new instructional strategies — for achieving these goals. This second and final report from the evaluation relies on both qualitative and quantitative data to examine the implementation of these focal strategies

The human gut colonizer Blastocystis respires using Complex II and alternative oxidase to buffer transient oxygen fluctuations in the gut

Blastocystis is the most common eukaryotic microbe in the human gut. It is linked to irritable bowel syndrome (IBS), but its role in disease has been contested considering its widespread nature. This organism is well adapted to its anoxic niche and lacks typical eukaryotic features such as a cytochrome-driven mitochondrial electron transport. Although generally considered a strict or obligate anaerobe, its genome encodes an alternative oxidase. Alternative oxidases are energetically wasteful enzymes as they are non-protonmotive and energy is liberated in heat, but they are considered to be involved in oxidative stress protective mechanisms. Our results demonstrate that the Blastocystis cells themselves respire oxygen via this alternative oxidase thereby casting doubt on its strict anaerobic nature. Inhibition experiments using alternative oxidase and Complex II specific inhibitors clearly demonstrate their role in cellular respiration. We postulate that the alternative oxidase in Blastocystis is used to buffer transient oxygen fluctuations in the gut and that it likely is a common colonizer of the human gut and not causally involved in IBS. Additionally the alternative oxidase could act as a protective mechanism in a dysbiotic gut and thereby explain the absence of Blastocystis in established IBS environments