Effects of physical environment factors on worker's health in micro and small sized industries of Pakistan

Background: Physical and environmental factors can affect both job performance and job satisfaction of the workers. Despite of the progress and improvement made for occupational safety and health, work environment especially in low and middle income countries is still hazardous for the workers. A large number of work related injuries and occupational accidents happens around the world each year. This research project aims to map work environment conditions and impact of physical environmental factors on occupational health in Punjab – Pakistan. Methods: Total eight micro and small industries in Lahore and Gujaranwala were visited during winter and summer season separately. Physical factors of light, noise and temperature were recorded for six hours during winter. A quantitive questionnaire was filled from 138 workers and an inspection of workplace was made by using ILO ergonomics checklist. Modified Testo 177 and Lascar data loggers were used to measure air (ta), globe (tg), natural wet bulb (tnw) temperatures and relative humidity (RH) to calculate the WBGT index. Result: Mean age of workers was 28.6 ± 10.5 years working for 8.8 ± 1.5 hours a day at a metabolic rate of 165 W/m2 (ISO 7243 level of exertion) and had 0.5 – 1 hour rest. In cold season the average indoor WBGT was 16.0 ± 2.5 ºC and in hot season the average indoor WBGT was 29.9 ± 5.5 ºC and indoor air velocity was 0.7 ± 0.3 m/s. Noise was recorded for time weightage average (TWA) and recorded a range of 73.1 dB (A) to 91.7 dB (A). Minimum intensity of 41.5 lux for light was recorded in one industry. Conclusion: A noise level of less than 85 dB (A) and light of 400 lux to 800 lux will improve physical and psychosocial work environment. Heat stress monitoring policy can be implemented by using ISO 7243. ILO ergonomic checklist can prove an important tool to make assessment and recommendations for working environments in Pakistan. Key Words: WBGT, Physical and environmental factors, Occupational healt

Multi-objective optimization of turning titanium-based alloy Ti-6Al-4V under dry, wet, and cryogenic conditions using gray relational analysis (GRA).

In modern manufacturing industries, the importance of multi-objective optimization cannot be overemphasized particularly when the desired responses are differing in nature towards each other. With the emergence of new technologies, the need to achieve overall efficiency in terms of energy, output, and tooling is on the rise. Resultantly, endeavor is to make the machining process sustainable, productive, and efficient simultaneously. In this research, the effects of machining parameters (feed, cutting speed, depth of cut, and cutting condition including dry, wet, and cryogenic) were analyzed. Since sustainable production demands a balance between production quality and energy consumption, therefore, response parameters including specific cutting energy, tool wear, surface roughness, and material removal rate were considered. Taguchi-gray integrated approach was adopted in this study. Multi-objective function was developed using gray relational methodology, and its regression analysis was conducted. Response surface optimization was carried out to optimize the formulated multi-objective function and derive the optimum machining parameters. Concurrent responses were optimized with best-suited values of input parameters to make the most out of the machining process. Analysis of variance results showed that feed is the most effective parameter followed by cutting condition in terms of overall contribution in multi-objective function. The proposed optimum parameters resulted in improvement of tool wear and surface roughness by 30% and 22%, respectively, whereas specific cutting energy was reduced by 4%

Statistical analysis of energy consumption, tool wear and surface roughness in machining of Titanium alloy (Ti-6Al-4V) under dry, wet and cryogenic conditions.

Productivity and economy are key elements of any sustainable manufacturing system. While productivity is associated to quantity and quality, economy focuses on energy efficient processes achieving an overall high output to input ratio. Machining of hard-to-cut materials has always posed a challenge due to increased tool wear and energy loss. Cryogenics have emerged as an effective means to improve sustainability in the recent past. In the present research the use of cooling conditions has been investigated as an input variable to analyze its effect on tool wear, specific cutting energy and surface roughness in combination with other input machining parameters of feed rate, cutting speed and depth of cut. Experimental design was based on Taguchi design of experiment. Analysis of Variance (ANOVA) was carried out to ascertain the contribution ratio of each input. Results showed the positive effect of coolant usage, particularly cryogenic, on process responses. Tool wear was improved by 33% whereas specific cutting energy and surface roughness were improved by 10% and 9% respectively by adapting the optimum machining conditions

Factors associated with month 2 smear non-conversion among category 1 tuberculosis patients in Karachi, Pakistan

Predictors of smear non-conversion at baseline can help identify cases at risk for failure of tuberculosis treatment. Retrospective data for smear-positive Category 1 patients in Karachi, Pakistan, was analyzed. Predictors of sputum conversion were determined using multiple logistic regression with sputum conversion as outcome variable and patient demographics, baseline weight, baseline sputum smear grade, case-finding approach as explanatory variables. Age ≥35 years, baseline sputum grade of 3+ were significantly associated with predicting sputum smear positivity at month 2 of treatment. Monitoring compliance to TB treatment should be considered amongst older patients and those with a high sputum grade at baseline

Common Genotypes of Hepatitis B virus prevalent in Injecting drug abusers (addicts) of North West Frontier Province of Pakistan

<p>Abstract</p> <p>Background</p> <p>The epidemiological significance of Hepatitis B virus genotypes has been well established and becoming an essential concern day by day however, much little is known about the mixed infection with more than one Hepatitis B virus genotypes and their clinical relevance.</p> <p>Methods</p> <p>Intravenous drug abusers are considered as a major risk group for the acquisition and transmission of blood borne infections like hepatitis B, however, in Pakistan, no such data has ever been reported about the epidemiology of HBV and its genotypes in Injecting Drug Users. 250 individuals were analyzed for hepatitis B virus genotypes after prior screening with serological assay for the detection of HBsAg.</p> <p>Results</p> <p>56 (22.4%) individuals were found positive on ELSIA for HBsAg. The genotype distribution was found to be as: genotype D, 62.5%; genotype A, 8.92% while 28.57% individuals were found to be infected with a mixture of genotype A and D.</p> <p>Conclusion</p> <p>There is an urgent need of the time to develop public health care policies with special emphasis towards the control of HBV transmission through high risk groups especially Injecting Drug Users.</p

Newcastle disease virus induces testicular damage and disrupts steroidogenesis in specific pathogen free roosters

Newcastle disease (ND), which is caused by Newcastle disease virus (NDV), can cause heavy economic losses to the poultry industry worldwide. It is characterised by extensive pathologies of the digestive, respiratory, and nervous systems and can cause severe damage to the reproductive system of egg-laying hens. However, it is unknown whether NDV replicates in the male reproductive system of chickens and induces any pathologies. In this study, we selected a representative strain (i.e. ZJ1) of the most common genotype (i.e. VII) of NDV to investigate whether NDV can induce histological, hormonal, and inflammatory responses in the testes of specific pathogen free (SPF) roosters. NDV infection increased the expression of toll like receptor TLR3, TLR7, MDA5, IFN-α, IFN-β, IFN-γ, IL-8, and CXCLi1 in the testes of NDV-infected roosters at 5 days post-infection (dpi). Severe histological changes, including decrease in the number of Sertoli cells and individualized, shrunken spermatogonia with pyknotic nuclei, were observed at 3 dpi. At 5 dpi, the spermatogenic columns were disorganized, and there were fewer cells, which were replaced by necrotic cells, lipid vacuoles, and proteinaceous homogenous material. A significant decrease in the plasma concentrations of testosterone and luteinizing hormone (LH) and the mRNA expression of their receptors in the testes, steroidogenic acute regulatory protein, cytochrome P450 side-chain cleavage enzyme, and 3β-hydroxysteroid dehydrogenase in the NDV-infected group was observed relative to those in the control group (P < 0.05). Collectively, these results indicate that NDV infection induces a severe inflammatory response and histological changes, which decrease the steroidogenesis. © 2020 The Author(s)

Relationship between the use of drugs and changes in body weight among patients: A systematic review and meta-analysis

Purpose: To investigate the impact of drugs on the body weight of patients.Methods: All the randomized controlled trials that evaluated the impact of medications on the body weight of patients were searched in various databases. Studies quantifying the impact of drugs on body weight when compared to placebo or any other treatment were considered for this review. Moreover, the quantitative synthesis of evidence was also performed by generating the forest plot.Results: A total of 20 studies involving 18,547 participants were included in the current review. Weight gains ranging from 0.5 to 2.6 kg were associated with the use of pioglitazone, espindolol, brexpiprazole, glimepiride and ezogabine while weight loss ranging from 1.1 to 12 kg was linked with the use of betahistine, naltrexone, bupropion, liraglutide, phentermine, topiramate, orlistat, zonisamide, duloxetine, semaglutide, metformin and linagliptin. The quantitative synthesis suggested that drugs can significantly reduce body weight by -0.53 kg (CI 95 % -1.01, -0.04, p &lt; 0.04) when compared to standard treatment.Conclusion: The findings of this review suggest substantial association of drugs and weight change during pharmacotherapy. Pioglitzone, brexpiprazole, espindolol, ezogabine and glimepiride cause weight gain while naltrexone, bupropion, betahistine, topiramate, phentermine, zonisamide, semaglutide, linagliptin, liraglutide, orlistat, duloxetine and metformin were associated with weight loss. Drug-induced changes in body weight might cause serious consequences and should be addressed before initiating treatment

Serology based disease status of Pakistani population infected with Hepatitis B virus

<p>Abstract</p> <p>Background</p> <p>The infection rate of hepatitis B virus is continuously increasing in Pakistan. Therefore, a comprehensive study of epidemiological data is the need of time.</p> <p>Methods</p> <p>A total of 1300 individuals were screened for HBV infection markers including HBsAg, anti-HBsAg, HBeAg and anti-HBcAg. The association of these disease indicators was compared with patients' epidemiological characteristics like age, socio-economic status and residential area to analyze and find out the possible correlation among these variables and the patients disease status.</p> <p>Results</p> <p>52 (4%) individuals were found positive for HBsAg with mean age 23.5 ± 3.7 years. 9.30%, 33.47% and 12% individuals had HBeAg, antibodies for HBsAg, and antibodies for HBcAg respectively. HBsAg seropositivity rate was significantly associated (<it>p </it>= 0.03) with the residing locality indicating high infection in rural areas. Antibodies titer against HBsAg decreased with the increasing age reflecting an inverse correlation.</p> <p>Conclusion</p> <p>Our results indicate high prevalence rate of Hepatitis B virus infection and nationwide vaccination campaigns along with public awareness and educational programs are needed to be practiced urgently.</p