27 research outputs found
Carbamazepine Withdrawal in Children With Previous Symptomatic Partial Epilepsy: Effects on Neuropsychologic Function
Effects of a Behavioral Intervention on Epileptic Seizure Behavior and Paroxysmal Activity: A Systematic Replication of Three Cases of Children with Intractable Epilepsy
The genetic architecture of sexually selected traits in two natural populations of Drosophila montana
The work was supported by the National Environment Research Council (grant NE/E015255/1 to MGR and RKB) and the Academy of Finland (project 132619 to AH).We investigated the genetic architecture of courtship song and cuticular hydrocarbon traits in two phygenetically distinct populations of Drosophila montana. To study natural variation in these two important traits, we analysed within-population crosses among individuals sampled from the wild. Hence, the genetic variation analysed should represent that available for natural and sexual selection to act upon. In contrast to previous between-population crosses in this species, no major quantitative trait loci (QTLs) were detected, perhaps because the between-population QTLs were due to fixed differences between the populations. Partitioning the trait variation to chromosomes suggested a broadly polygenic genetic architecture of within-population variation, although some chromosomes explained more variation in one population compared with the other. Studies of natural variation provide an important contrast to crosses between species or divergent lines, but our analysis highlights recent concerns that segregating variation within populations for important quantitative ecological traits may largely consist of small effect alleles, difficult to detect with studies of moderate power.PostprintPeer reviewe
Effects of Carbamazepine on Psychomotor Performance in Children as a Function of Drug Concentration, Seizure Type, and Time of Medication
Comparing the Cognitive Effects of Phenytoin and Carbamazepine in Long-Term Monotherapy: A Two-Year Follow-Up
Proximity of signallers can maintain sexual signal variation under stabilizing selection
How sexual communication systems can evolve under stabilizing selection is still a paradox in evolutionary biology. In moths, females emit a species-specific sex pheromone, consisting of a blend of biochemically related components, to which males are attracted. Although males appear to exert strong stabilizing selection on female pheromone, these blends seem to have evolved rapidly, as evidenced by ~120,000 moth species. Here we propose and test a “proximity model” wherein two females that vary in their relative attractiveness to males, can both benefit from calling in close proximity to each other. In a field study, we show that (1) artificially selected unattractive females can achieve mating rates comparable to attractive females if they signal in close proximity to attractive females, and (2) attractive females benefit from higher mating rates when signalling in close proximity to unattractive females. We propose that frequency-dependent behavioural and spatial interactions can sustain signal variation within populations even when these signals are under stabilizing selection