The effect of feedback and information on children's pedometer step counts at school

This study examined whether feedback or feedback plus physical activity information could increase the number of pedometer steps taken during 1 school week. One hundred seventy-seven students (mean age 9.124 ± 1.11 years) in three elementary schools participated. Schools were randomly assigned to control (CON), feedback (FB), or feedback plus information (FB+I) groups. Children wore pedometers during school time for 5 consecutive weekdays. The total steps of the groups were recorded at the end of each school day, with students in the FB and FB+I groups free to view their step counts. In addition, the FB+I group received information and ideas about how they could increase their daily steps. The CON group received no step-count feedback or information. Students in the FB+I group achieved significantly more steps per minute (17.17 ± 4.87) than those in the FB (13.77 ± 4.06, p = 0.003) and CON (12.41 ± 3.12, p = 0.0001) groups. Information, as well as step-count feedback, increased elementary students’ school-based physical activity (number of steps) in the short term. A longer intervention period is necessary to assess the sustained impact of this type of approach

The mutational meltdown in asexual populations

Loss of fitness due to the accumulation of deleterious mutations appears to be inevitable in small, obligately asexual populations, as these are incapable of reconstituting highly fit genotypes by recombination or back mutation. The cumulative buildup of such mutations is expected to lead to an eventual reduction in population size, and this facilitates the chance accumulation of future mutations. This synergistic interaction between population size reduction and mutation accumulation leads to an extinction process known as the mutational meltdown, and provides a powerful explanation for the rarity of obligate asexuality. We give an overview of the theory of the mutational meltdown, showing how the process depends on the demographic properties of a population, the properties of mutations, and the relationship between fitness and number of mutations incurred

Hierarchy of integrable Hamiltonians describing of nonlinear n-wave interaction

In the paper we construct an hierarchy of integrable Hamiltonian systems which describe the variation of n-wave envelopes in nonlinear dielectric medium. The exact solutions for some special Hamiltonians are given in terms of elliptic functions of the first kind.Comment: 17 page

Hawking radiation from "phase horizons" in laser filaments?

Belgiorno et al have reported on experiments aiming at the detection of (the analogue of) Hawking radiation using laser filaments [F. Belgiorno et al, Phys. Rev. Lett. 105, 203901 (2010)]. They sent intense focused Bessel pulses into a non-linear dielectric medium in order to change its refractive index via the Kerr effect and saw creation of photons orthogonal to the direction of travel of the pluses. Since the refractive index change in the pulse generated a "phase horizon" (where the phase velocity of these photons equals the pulse speed), they concluded that they observed the analogue of Hawking radiation. We study this scenario in a model with a phase horizon and a phase velocity very similar to that of their experiment and find that the effective metric does not quite correspond to a black hole. The photons created in this model are not due to the analogue of black hole evaporation but have more similarities to cosmological particle creation. Nevertheless, even this effect cannot explain the observations -- unless the pulse has significant small scale structure in both the longitudinal and transverse dimensions.Comment: 13 pages RevTeX, 2 figure

Using Wave-Packet Interferometry to Monitor the External Vibrational Control of Electronic Excitation Transfer

We investigate the control of electronic energy transfer in molecular dimers through the preparation of specific vibrational coherences prior to electronic excitation, and its observation by nonlinear wave-packet interferometry. Laser-driven coherent nuclear motion can affect the instantaneous resonance between site-excited electronic states and thereby influence short-time electronic excitation transfer (EET). We first illustrate this control mechanism with calculations on a dimer whose constituent monomers undergo harmonic vibrations. We then consider the use of nonlinear wave-packet interferometry (nl-WPI) experiments to monitor the nuclear dynamics accompanying EET in general dimer complexes following impulsive vibrational excitation by a sub-resonant control pulse (or control pulse sequence). In measurements of this kind, two pairs of polarized phase-related femtosecond pulses following the control pulse generate superpositions of coherent nuclear wave packets in optically accessible electronic states. Interference contributions to the time- and frequency-integrated fluorescence signal due to overlaps among the superposed wave packets provide amplitude-level information on the nuclear and electronic dynamics. We derive the basic expression for a control-pulse-dependent nl-WPI signal. The electronic transition moments of the constituent monomers are assumed to have a fixed relative orientation, while the overall orientation of the complex is distributed isotropically. We include the limiting case of coincident arrival by pulses within each phase-related pair in which control-influenced nl-WPI reduces to a fluorescence-detected pump-probe difference experiment. Numerical calculations of pump-probe signals based on these theoretical expressions are presented in the following paper

Oxidative Stress Resulting From Helicobacter pylori Infection Contributes to Gastric Carcinogenesis.

Helicobacter pylori is a gram-negative, microaerophilic bacterium that infects the stomach and can lead to, among other disorders, the development of gastric cancer. The inability of the host to clear the infection results in a chronic inflammatory state with continued oxidative stress within the tissue. Reactive oxygen species and reactive nitrogen species produced by the immune and epithelial cells damage the host cells and can result in DNA damage. H pylori has evolved to evoke this damaging response while blunting the host's efforts to kill the bacteria. This long-lasting state with inflammation and oxidative stress can result in gastric carcinogenesis. Continued efforts to better understand the bacterium and the host response will serve to prevent or provide improved early diagnosis and treatment of gastric cancer

Distinct phosphorylation clusters determines the signalling outcome of the free fatty acid receptor FFA4/GPR120

It is established that long-chain free fatty acids including ω-3 fatty acids mediate an array of biological responses through members of the free fatty acid receptor family, which includes FFA4. However, the signalling mechanisms and modes of regulation of this receptor class remain unclear. Here we employ mass spectrometry to determine that phosphorylation of mouse (m)FFAR4 occurs at five serine and threonine residues clustered in two separable regions of the C terminal tail, designated cluster 1 (Thr347, Thr349 and Ser350) and cluster 2 (Ser357 and Ser361). Mutation of these phospho-acceptor sites to alanine completely prevented phosphorylation of mFFA4 but did not limit receptor coupling to ERK1/2 activation. Rather an inhibitor of Gq/11 proteins completely prevented receptor signalling to ERK1/2. In contrast, the recruitment of arrestin 3, receptor internalization and activation of Akt were regulated by mFFA4 phosphorylation. The analysis of mFFA4 phosphorylation-dependent signalling was extended further by selective mutations of the phospho-acceptor sites. Mutations within cluster 2 did not affect agonist activation of Akt but instead significantly compromised receptor internalization and arrestin 3 recruitment. Distinctly, mutation of the phospho-acceptor sites within cluster 1 had no effect on receptor internalization and a less extensive effect on arrestin 3 recruitment, but significantly uncoupled the receptor from Akt activation. These unique observations define differential effects on signalling mediated by phosphorylation at distinct locations. This hallmark feature supports the possibility that the signalling outcome of mFFA4 activation can be determined by the pattern of phosphorylation (phosphorylation barcode) at the C-terminus of the receptor

Evidence for Recent Wet-Based Crater Glaciation in Tempe Terra, Mars.

[Introduction] Mars’ mid-latitudes host abundant putative debris-covered water-ice glaciers (viscous flow features; VFF). Eskers emerging from 110-150 Myr-old VFF in Phlegra Montes and Tempe Terra provide evidence for rare occurences of past, localized basal melting of their parent VFF, despite the cold climates of the late Amazonian (see this conf.). Eskers are sinuous ridges comprising glaciofluvial sediment deposited by meltwater flowing through tunnels within glacial ice. Here, we describe a population of sinuous ridges emerging from VFF in an unnamed ~45 km-diameter crater (38.47 N, 72.43 W) in Tempe Terra, ~600 km from the VFF-linked esker identified by Butcher et al. We consider two working hypotheses for the formation of the sinuous ridges; that they are either (1) eskers formed by melting of the glaciers from which they emerge, or (2) topographically inverted fluvial channels which formed prior to glaciation of the crater. We present observations from preliminary geomorphic mapping of the crater to start to test those hypotheses

Breaking of the overall permutation symmetry in nonlinear optical susceptibilities of one-dimensional periodic dimerized Huckel model

Based on infinite one-dimensional single-electron periodic models of trans-polyacetylene, we show analytically that the overall permutation symmetry of nonlinear optical susceptibilities is, albeit preserved in the molecular systems with only bound states, no longer generally held for the periodic systems. The overall permutation symmetry breakdown provides a fairly natural explanation to the widely observed large deviations of Kleinman symmetry for periodic systems in off-resonant regions. Physical conditions to experimentally test the overall permutation symmetry break are discussed.Comment: 7 pages, 1 figur

Microarray analysis of whole genome expression of intracellular Mycobacterium tuberculosis

Analysis of the changing mRNA expression profile of Mycobacterium tuberculosis though the course of infection promises to advance our understanding of how mycobacteria are able to survive the host immune response. The difficulties of sample extraction from distinct mycobacterial populations, and of measuring mRNA expression profiles of multiple genes has limited the impact of gene expression studies on our interpretation of this dynamic infection process. The development of whole genome microarray technology together with advances in sample collection have allowed the expression pattern of the whole M. tuberculosis genome to be compared across a number of different in vitro conditions, murine and human tissue culture models and in vivo infection samples. This review attempts to produce a summative model of the M. tuberculosis response to infection derived from or reflected in these gene expression datasets. The mycobacterial response to the intracellular environment is characterised by the utilisation of lipids as a carbon source and the switch from aerobic/microaerophilic to anaerobic respiratory pathways. Other genes induced in the macrophage phagosome include those likely to be involved in the maintenance of the cell wall and genes related to DNA damage, heat shock, iron sequestration and nutrient limitation. The comparison of transcriptional data from in vitro models of infection with complex in vivo samples, together with the use of bacterial RNA amplification strategies to sample defined populations of bacilli, should allow us to make conclusions about M. tuberculosis physiology and host microenvironments during natural infection