3,276 research outputs found
Prevalence and associated harm of engagement in self-Asphyxial behaviours ('choking game') in young people:A systematic review
OBJECTIVE: To assess the prevalence of engagement in self-asphyxial (risk-taking) behaviour (SAB) (‘choking game’) and associated morbidity and mortality in children and young people up to age 20. DESIGN: Systematic literature review. SEARCH STRATEGY: Electronic database search of MEDLINE, Embase, PsycINFO, CINAHL, PubMed, Web of Science Core Collection, BIOSIS citation index and the Cochrane register with no language or date limits applied. References of key papers were reviewed, and experts were contacted to identify additional relevant papers. ELIGIBILITY CRITERIA: Systematic reviews, cross-sectional, cohort and case–control studies, and case reports examining SAB with regard to individuals aged 0–20 years, without explicitly stated autoerotic, suicidal or self-harm intentions were included. RESULTS: Thirty-six relevant studies were identified, and SAB was reported in 10 countries. In North America, France and Colombia, awareness of SAB ranged from 36% to 91% across studies/settings, and the median lifetime prevalence of engagement in SAB was 7.4%. Six studies identified the potential for SAB to be associated with engagement in other risk behaviours. Ninety-nine fatal cases were reported. Of the 24 cases described in detail, most occurred when individuals engaged in SAB alone and used a ligature. CONCLUSIONS: The current evidence on SAB among young people is limited, and stems predominantly from North America and France. Awareness of SAB among young people is high, and engagement varies by setting. Further research is needed to understand the level of risk and harm associated with SAB, and to determine the appropriate public health response
Hysteresis phenomenon in turbulent convection
Coherent large-scale circulations of turbulent thermal convection in air have
been studied experimentally in a rectangular box heated from below and cooled
from above using Particle Image Velocimetry. The hysteresis phenomenon in
turbulent convection was found by varying the temperature difference between
the bottom and the top walls of the chamber (the Rayleigh number was changed
within the range of ). The hysteresis loop comprises the one-cell
and two-cells flow patterns while the aspect ratio is kept constant (). We found that the change of the sign of the degree of the anisotropy of
turbulence was accompanied by the change of the flow pattern. The developed
theory of coherent structures in turbulent convection (Elperin et al. 2002;
2005) is in agreement with the experimental observations. The observed coherent
structures are superimposed on a small-scale turbulent convection. The
redistribution of the turbulent heat flux plays a crucial role in the formation
of coherent large-scale circulations in turbulent convection.Comment: 10 pages, 9 figures, REVTEX4, Experiments in Fluids, 2006, in pres
Selecting a single orientation for millimeter sized graphene sheets
We have used Low Energy Electron Microscopy (LEEM) and Photo Emission
Electron Microscopy (PEEM) to study and improve the quality of graphene films
grown on Ir(111) using chemical vapor deposition (CVD). CVD at elevated
temperature already yields graphene sheets that are uniform and of monatomic
thickness. Besides domains that are aligned with respect to the substrate,
other rotational variants grow. Cyclic growth exploiting the faster growth and
etch rates of the rotational variants, yields films that are 99 % composed of
aligned domains. Precovering the substrate with a high density of graphene
nuclei prior to CVD yields pure films of aligned domains extending over
millimeters. Such films can be used to prepare cluster-graphene hybrid
materials for catalysis or nanomagnetism and can potentially be combined with
lift-off techniques to yield high-quality, graphene based electronic devices
Variational bound on energy dissipation in plane Couette flow
We present numerical solutions to the extended Doering-Constantin variational
principle for upper bounds on the energy dissipation rate in turbulent plane
Couette flow. Using the compound matrix technique in order to reformulate this
principle's spectral constraint, we derive a system of equations that is
amenable to numerical treatment in the entire range from low to asymptotically
high Reynolds numbers. Our variational bound exhibits a minimum at intermediate
Reynolds numbers, and reproduces the Busse bound in the asymptotic regime. As a
consequence of a bifurcation of the minimizing wavenumbers, there exist two
length scales that determine the optimal upper bound: the effective width of
the variational profile's boundary segments, and the extension of their flat
interior part.Comment: 22 pages, RevTeX, 11 postscript figures are available as one
uuencoded .tar.gz file from [email protected]
SigsPack, a package for cancer mutational signatures
BACKGROUND: Mutational signatures are specific patterns of somatic mutations introduced into the genome by oncogenic processes. Several mutational signatures have been identified and quantified from multiple cancer studies, and some of them have been linked to known oncogenic processes. Identification of the processes contributing to mutations observed in a sample is potentially informative to understand the cancer etiology. RESULTS: We present here SigsPack, a Bioconductor package to estimate a sample's exposure to mutational processes described by a set of mutational signatures. The package also provides functions to estimate stability of these exposures, using bootstrapping. The performance of exposure and exposure stability estimations have been validated using synthetic and real data. Finally, the package provides tools to normalize the mutation frequencies with respect to the tri-nucleotide contents of the regions probed in the experiment. The importance of this effect is illustrated in an example. CONCLUSION: SigsPack provides a complete set of tools for individual sample exposure estimation, and for mutation catalogue & mutational signatures normalization
Wave function mapping in graphene quantum dots with soft confinement
Using low-temperature scanning tunneling spectroscopy, we map the local
density of states (LDOS) of graphene quantum dots supported on Ir(111). Due to
a band gap in the projected Ir band structure around the graphene K point, the
electronic properties of the QDs are dominantly graphene-like. Indeed, we
compare the results favorably with tight binding calculations on the honeycomb
lattice based on parameters derived from density functional theory. We find
that the interaction with the substrate near the edge of the island gradually
opens a gap in the Dirac cone, which implies soft-wall confinement.
Interestingly, this confinement results in highly symmetric wave functions.
Further influences of the substrate are given by the known moir{\'e} potential
and a 10% penetration of an Ir surface resonanceComment: 7 pages, 11 figures, DFT calculations directly showing the origin of
soft confinment, correct identification of the state penetrating from Ir(111)
into graphen
The mechanism of caesium intercalation of graphene
Properties of many layered materials, including copper- and iron-based
superconductors, topological insulators, graphite and epitaxial graphene can be
manipulated by inclusion of different atomic and molecular species between the
layers via a process known as intercalation. For example, intercalation in
graphite can lead to superconductivity and is crucial in the working cycle of
modern batteries and supercapacitors. Intercalation involves complex diffusion
processes along and across the layers, but the microscopic mechanisms and
dynamics of these processes are not well understood. Here we report on a novel
mechanism for intercalation and entrapment of alkali-atoms under epitaxial
graphene. We find that the intercalation is adjusted by the van der Waals
interaction, with the dynamics governed by defects anchored to graphene
wrinkles. Our findings are relevant for the future design and application of
graphene-based nano-structures. Similar mechanisms can also play a role for
intercalation of layered materials.Comment: 8 pages, 7 figures in published form, supplementary information
availabl
In situ observation of stress relaxation in epitaxial graphene
Upon cooling, branched line defects develop in epitaxial graphene grown at
high temperature on Pt(111) and Ir(111). Using atomically resolved scanning
tunneling microscopy we demonstrate that these defects are wrinkles in the
graphene layer, i.e. stripes of partially delaminated graphene. With low energy
electron microscopy (LEEM) we investigate the wrinkling phenomenon in situ.
Upon temperature cycling we observe hysteresis in the appearance and
disappearance of the wrinkles. Simultaneously with wrinkle formation a change
in bright field imaging intensity of adjacent areas and a shift in the moire
spot positions for micro diffraction of such areas takes place. The stress
relieved by wrinkle formation results from the mismatch in thermal expansion
coefficients of graphene and the substrate. A simple one-dimensional model
taking into account the energies related to strain, delamination and bending of
graphene is in qualitative agreement with our observations.Comment: Supplementary information: S1: Photo electron emission microscopy and
LEEM measurements of rotational domains, STM data of a delaminated bulge
around a dislocation. S2: Movie with increasing brightness upon wrinkle
formation as in figure 4. v2: Major revision including new experimental dat
Continuum-type stability balloon in oscillated granular layers
The stability of convection rolls in a fluid heated from below is limited by
secondary instabilities, including the skew-varicose and crossroll
instabilities. We observe a stability boundary defined by the same
instabilities in stripe patterns in a vertically oscillated granular layer.
Molecular dynamics simulations show that the mechanism of the skew-varicose
instability in granular patterns is similar to that in convection. These
results suggest that pattern formation in granular media can be described by
continuum models analogous to those used in fluid systems.Comment: 4 pages, 6 ps figs, submitted to PR
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