Advancing climate change health adaptation through implementation science

To date, there are few examples of implementation science studies that help guide climate-related health adaptation. Implementation science is the study of methods to promote the adoption and integration of evidence-based tools, interventions, and policies into practice to improve population health. These studies can provide the needed empirical evidence to prioritise and inform implementation of health adaptation efforts. This Personal View discusses five case studies that deployed disease early warning systems around the world. These cases studies illustrate challenges to deploying early warning systems and guide recommendations for implementation science approaches to enhance future research. We propose theory-informed approaches to understand multilevel barriers, design strategies to overcome those barriers, and analyse the ability of those strategies to advance the uptake and scale-up of climate-related health interventions. These findings build upon previous theoretical work by grounding implementation science recommendations and guidance in the context of real-world practice, as detailed in the case studies.Peer ReviewedArticle signat per 14 autors/es: Gila Neta, PhD; William Pan, DrPH; Prof Kristie Ebi, PhD; Daniel F Buss, PhD; Trisha Castranio, BS; Prof Rachel Lowe, PhD; Sadie J Ryan, PhD; Anna M Stewart-Ibarra, PhD; Limb K Hapairai, PhD; Meena Sehgal, MPH; Prof Michael C Wimberly, PhD; Leslie Rollock, DrPH; Prof Maureen Lichtveld, MD; John Balbus, MD"Postprint (published version

KK-duality for self-similar groupoid actions on graphs

We extend Nekrashevych's $KK$-duality for $C^*$-algebras of regular, recurrent, contracting self-similar group actions to regular, contracting self-similar groupoid actions on a graph, removing the recurrence condition entirely and generalising from a finite alphabet to a finite graph. More precisely, given a regular and contracting self-similar groupoid $(G,E)$ acting faithfully on a finite directed graph $E$, we associate two $C^*$-algebras, $\mathcal{O}(G,E)$ and $\widehat{\mathcal{O}}(G,E)$, to it and prove that they are strongly Morita equivalent to the stable and unstable Ruelle C*-algebras of a Smale space arising from a Wieler solenoid of the self-similar limit space. That these algebras are Spanier-Whitehead dual in $KK$-theory follows from the general result for Ruelle algebras of irreducible Smale spaces proved by Kaminker, Putnam, and the last author.Comment: File updated to make several corrections. Example 8.15 adde

Performance Evaluation - Annual Report Year 3

This report describes the work done and results obtained in third year of the CATNETS project. Experiments carried out with the different configurations of the prototype are reported and simulation results are evaluated with the CATNETS metrics framework. The applicability of the Catallactic approach as market model for service and resource allocation in application layer networks is assessed based on the results and experience gained both from the prototype development and simulations. --Grid Computing

Performance Evaluation - Annual Report Year 3

This report describes the work done and results obtained in third year of the CATNETS project. Experiments carried out with the different configurations of the prototype are reported and simulation results are evaluated with the CATNETS metrics framework. The applicability of the Catallactic approach as market model for service and resource allocation in application layer networks is assessed based on the results and experience gained both from the prototype development and simulations

Performance evaluation - annual report year 3

This report describes the work done and results obtained in third year of the CATNETS project. Experiments carried out with the different configurations of the prototype are reported and simulation results are evaluated with the CATNETS metrics framework. The applicability of the Catallactic approach as market model for service and resource allocation in application layer networks is assessed based on the results and experience gained both from the prototype development and simulations

Epidemiologic investigation of immune-mediated polyradiculoneuropathy among abattoir workers exposed to porcine brain

Background In October 2007, a cluster of patients experiencing a novel polyradiculoneuropathy was identified at a pork abattoir (Plant A). Patients worked in the primary carcass processing area (warm room); the majority processed severed heads (head-table). An investigation was initiated to determine risk factors for illness. Methods and Results Symptoms of the reported patients were unlike previously described occupational associated illnesses. A case-control study was conducted at Plant A. A case was defined as evidence of symptoms of peripheral neuropathy and compatible electrodiagnostic testing in a pork abattoir worker. Two control groups were used - randomly selected non-ill warm-room workers (n = 49), and all non-ill head-table workers (n = 56). Consenting cases and controls were interviewed and blood and throat swabs were collected. The 26 largest U.S. pork abattoirs were surveyed to identify additional cases. Fifteen cases were identified at Plant A; illness onsets occurred during May 2004–November 2007. Median age was 32 years (range, 21–55 years). Cases were more likely than warm-room controls to have ever worked at the head-table (adjusted odds ratio [AOR], 6.6; 95% confidence interval [CI], 1.6–26.7), removed brains or removed muscle from the backs of heads (AOR, 10.3; 95% CI, 1.5–68.5), and worked within 0–10 feet of the brain removal operation (AOR, 9.9; 95% CI, 1.2–80.0). Associations remained when comparing head-table cases and head-table controls. Workers removed brains by using compressed air that liquefied brain and generated aerosolized droplets, exposing themselves and nearby workers. Eight additional cases were identified in the only two other abattoirs using this technique. The three abattoirs that used this technique have stopped brain removal, and no new cases have been reported after 24 months of follow up. Cases compared to controls had higher median interferon-gamma (IFNγ) levels (21.7 pg/ml; vs 14.8 pg/ml, P<0.001). Discussion This novel polyradiculoneuropathy was associated with removing porcine brains with compressed air. An autoimmune mechanism is supported by higher levels of IFNγ in cases than in controls consistent with other immune mediated illnesses occurring in association with neural tissue exposure. Abattoirs should not use compressed air to remove brains and should avoid procedures that aerosolize CNS tissue. This outbreak highlights the potential for respiratory or mucosal exposure to cause an immune-mediated illness in an occupational setting

Epidemiologic investigation of immune-mediated polyradiculoneuropathy among abattoir workers exposed to porcine brain

Background In October 2007, a cluster of patients experiencing a novel polyradiculoneuropathy was identified at a pork abattoir (Plant A). Patients worked in the primary carcass processing area (warm room); the majority processed severed heads (head-table). An investigation was initiated to determine risk factors for illness. Methods and Results Symptoms of the reported patients were unlike previously described occupational associated illnesses. A case-control study was conducted at Plant A. A case was defined as evidence of symptoms of peripheral neuropathy and compatible electrodiagnostic testing in a pork abattoir worker. Two control groups were used - randomly selected non-ill warm-room workers (n = 49), and all non-ill head-table workers (n = 56). Consenting cases and controls were interviewed and blood and throat swabs were collected. The 26 largest U.S. pork abattoirs were surveyed to identify additional cases. Fifteen cases were identified at Plant A; illness onsets occurred during May 2004–November 2007. Median age was 32 years (range, 21–55 years). Cases were more likely than warm-room controls to have ever worked at the head-table (adjusted odds ratio [AOR], 6.6; 95% confidence interval [CI], 1.6–26.7), removed brains or removed muscle from the backs of heads (AOR, 10.3; 95% CI, 1.5–68.5), and worked within 0–10 feet of the brain removal operation (AOR, 9.9; 95% CI, 1.2–80.0). Associations remained when comparing head-table cases and head-table controls. Workers removed brains by using compressed air that liquefied brain and generated aerosolized droplets, exposing themselves and nearby workers. Eight additional cases were identified in the only two other abattoirs using this technique. The three abattoirs that used this technique have stopped brain removal, and no new cases have been reported after 24 months of follow up. Cases compared to controls had higher median interferon-gamma (IFNγ) levels (21.7 pg/ml; vs 14.8 pg/ml, P<0.001). Discussion This novel polyradiculoneuropathy was associated with removing porcine brains with compressed air. An autoimmune mechanism is supported by higher levels of IFNγ in cases than in controls consistent with other immune mediated illnesses occurring in association with neural tissue exposure. Abattoirs should not use compressed air to remove brains and should avoid procedures that aerosolize CNS tissue. This outbreak highlights the potential for respiratory or mucosal exposure to cause an immune-mediated illness in an occupational setting

Stream biomonitoring using macroinvertebrates around the globe: a comparison of large-scale programs

Water quality agencies and scientists are increasingly adopting standardized sampling methodologies because of the challenges associated with interpreting data derived from dissimilar protocols. Here, we compare 13 protocols for monitoring streams from different regions and countries around the globe. Despite the spatially diverse range of countries assessed, many aspects of bioassessment structure and protocols were similar, thereby providing evidence of key characteristics that might be incorporated in a global sampling methodology. Similarities were found regarding sampler type, mesh size, sampling period, subsampling methods, and taxonomic resolution. Consistent field and laboratory methods are essential for merging data sets collected by multiple institutions to enable large-scale comparisons. We discuss the similarities and differences among protocols and present current trends and future recommendations for monitoring programs, especially for regions where large-scale protocols do not yet exist. We summarize the current state in one of these regions, Latin America, and comment on the possible development path for these techniques in this region. We conclude that several aspects of stream biomonitoring need additional performance evaluation (accuracy, precision, discriminatory power, relative costs), particularly when comparing targeted habitat (only the commonest habitat type) versus site-wide sampling (multiple habitat types), appropriate levels of sampling and processing effort, and standardized indicators to resolve dissimilarities among biomonitoring methods. Global issues such as climate change are creating an environment where there is an increasing need to have universally consistent data collection, processing and storage to enable large-scale trend analysis. Biomonitoring programs following standardized methods could aid international data sharing and interpretation.Keywords: Subsampling taxonomic resolution, Biomonitoring protocols, River management, Standardization, Biological assessmen