22,342 research outputs found
Quasi-static granular flow of ice mélange
We use Landsat 8 imagery to generate ice mĂ©lange velocity fields at Greenlandâs three most
productive outlet glaciers: Jakobshavn IsbrĂŠ, Helheim Glacier, and Kangerdlugssuaq Glacier. Winter velocity
fields are generally steady and highly uniform. Summer velocity fields, on the other hand, tend to be much
more variable and can be uniform, compressional, or extensional. We rarely observe compressional flow
at Jakobshavn IsbrĂŠ or extensional flow at Helheim Glacier, while both are observed at Kangerdlugssuaq
Glacier. Transverse velocity profiles from all three locations are suggestive of viscoplastic flow, in which
deformation occurs primarily in shear zones along the fjord walls. We analyze the transverse profiles in
the context of quasi-static flow using continuum rheologies for granular materials and find that the force
per unit width that ice mélange exerts on glacier termini increases exponentially with the ice mélange
length-to-width ratio and the effective coefficient of friction. Our estimates of ice mélange resistance are
consistent with other independent estimates and suggest that ice mélange may be capable of inhibiting
iceberg calving events, especially during winter. Moreover, our results provide geophysical-scale support for
constitutive relationships for granular materials and suggest a potential avenue for modeling ice mélange
dynamics with continuum models.From acknowledgments:
Funding for this project was provided by the U.S. National Science Foundation (DMR-1506446 and DMR-1506307).
Digital elevation models were provided by the Polar Geospatial Center under the U.S. National Science Foundation (OPP-1043681, OPP-1559691, and OPP-1542736)Ye
Quasi-static granular flow of ice mélange
We use Landsat 8 imagery to generate ice mĂ©lange velocity fields at Greenlandâs three most
productive outlet glaciers: Jakobshavn IsbrĂŠ, Helheim Glacier, and Kangerdlugssuaq Glacier. Winter velocity
fields are generally steady and highly uniform. Summer velocity fields, on the other hand, tend to be much
more variable and can be uniform, compressional, or extensional. We rarely observe compressional flow
at Jakobshavn IsbrĂŠ or extensional flow at Helheim Glacier, while both are observed at Kangerdlugssuaq
Glacier. Transverse velocity profiles from all three locations are suggestive of viscoplastic flow, in which
deformation occurs primarily in shear zones along the fjord walls. We analyze the transverse profiles in
the context of quasi-static flow using continuum rheologies for granular materials and find that the force
per unit width that ice mélange exerts on glacier termini increases exponentially with the ice mélange
length-to-width ratio and the effective coefficient of friction. Our estimates of ice mélange resistance are
consistent with other independent estimates and suggest that ice mélange may be capable of inhibiting
iceberg calving events, especially during winter. Moreover, our results provide geophysical-scale support for
constitutive relationships for granular materials and suggest a potential avenue for modeling ice mélange
dynamics with continuum models.From acknowledgments:
Funding for this project was provided by the U.S. National Science Foundation (DMR-1506446 and DMR-1506307).
Digital elevation models were provided by the Polar Geospatial Center under the U.S. National Science Foundation (OPP-1043681, OPP-1559691, and OPP-1542736)Ye
Quantifying flow and stress in ice mĂ©lange, the worldâs largest granular material.
Tidewater glacier fjords are often filled with a collection of calved icebergs, brash ice, and sea ice. For glaciers with high calving rates, this âm Ìelangeâ of ice can be jam-packed, so that the flow of ice fragments is mostly determined by granular interactions. In the jammed state, ice m Ìelange has been hypothesized to influence iceberg calving and capsize, dispersion and attenuation of ocean waves, injection of freshwater into fjords, and fjord circulation. However, detailed measurements of ice m Ìelange are lacking due to difficulties in instrumenting remote, ice-choked fjords. Here we characterize the flow and associated stress in icem Ìelange, using a combination of terrestrial radar data, laboratory experiments, and numerical simulations. We find that, during periods of terminus quiescence, ice m Ìelange experiences laminar flow over timescales of hours to days. The uniform flow fields are bounded by shear margins along fjord walls where force chains between granular icebergs terminate. In addition, the average force per unit width that is transmitted to the glacier terminus, which can exceed 107N/m, increases exponentially with them Ìelange length-to-width ratio. These âbuttressingâ forces are sufficiently high to inhibit the initiation of large-scale calving events, supporting the notion that ice m Ìelange can be viewed as a weak granular ice shelf that transmits stresses from fjord walls back to glacier termini.Ye
Nonlinear stabilitty for steady vortex pairs
In this article, we prove nonlinear orbital stability for steadily
translating vortex pairs, a family of nonlinear waves that are exact solutions
of the incompressible, two-dimensional Euler equations. We use an adaptation of
Kelvin's variational principle, maximizing kinetic energy penalised by a
multiple of momentum among mirror-symmetric isovortical rearrangements. This
formulation has the advantage that the functional to be maximized and the
constraint set are both invariant under the flow of the time-dependent Euler
equations, and this observation is used strongly in the analysis. Previous work
on existence yields a wide class of examples to which our result applies.Comment: 25 page
The inexorable resistance of inertia determines the initial regime of drop coalescence
Drop coalescence is central to diverse processes involving dispersions of
drops in industrial, engineering and scientific realms. During coalescence, two
drops first touch and then merge as the liquid neck connecting them grows from
initially microscopic scales to a size comparable to the drop diameters. The
curvature of the interface is infinite at the point where the drops first make
contact, and the flows that ensue as the two drops coalesce are intimately
coupled to this singularity in the dynamics. Conventionally, this process has
been thought to have just two dynamical regimes: a viscous and an inertial
regime with a crossover region between them. We use experiments and simulations
to reveal that a third regime, one that describes the initial dynamics of
coalescence for all drop viscosities, has been missed. An argument based on
force balance allows the construction of a new coalescence phase diagram
Statistical modelling of transcript profiles of differentially regulated genes
Background: The vast quantities of gene expression profiling data produced in microarray studies, and
the more precise quantitative PCR, are often not statistically analysed to their full potential. Previous
studies have summarised gene expression profiles using simple descriptive statistics, basic analysis of
variance (ANOVA) and the clustering of genes based on simple models fitted to their expression profiles
over time. We report the novel application of statistical non-linear regression modelling techniques to
describe the shapes of expression profiles for the fungus Agaricus bisporus, quantified by PCR, and for E.
coli and Rattus norvegicus, using microarray technology. The use of parametric non-linear regression models
provides a more precise description of expression profiles, reducing the "noise" of the raw data to
produce a clear "signal" given by the fitted curve, and describing each profile with a small number of
biologically interpretable parameters. This approach then allows the direct comparison and clustering of
the shapes of response patterns between genes and potentially enables a greater exploration and
interpretation of the biological processes driving gene expression.
Results: Quantitative reverse transcriptase PCR-derived time-course data of genes were modelled. "Splitline"
or "broken-stick" regression identified the initial time of gene up-regulation, enabling the classification
of genes into those with primary and secondary responses. Five-day profiles were modelled using the
biologically-oriented, critical exponential curve, y(t) = A + (B + Ct)Rt + Δ. This non-linear regression
approach allowed the expression patterns for different genes to be compared in terms of curve shape,
time of maximal transcript level and the decline and asymptotic response levels. Three distinct regulatory
patterns were identified for the five genes studied. Applying the regression modelling approach to
microarray-derived time course data allowed 11% of the Escherichia coli features to be fitted by an
exponential function, and 25% of the Rattus norvegicus features could be described by the critical
exponential model, all with statistical significance of p < 0.05.
Conclusion: The statistical non-linear regression approaches presented in this study provide detailed
biologically oriented descriptions of individual gene expression profiles, using biologically variable data to
generate a set of defining parameters. These approaches have application to the modelling and greater
interpretation of profiles obtained across a wide range of platforms, such as microarrays. Through careful
choice of appropriate model forms, such statistical regression approaches allow an improved comparison
of gene expression profiles, and may provide an approach for the greater understanding of common
regulatory mechanisms between genes
A qualitative study of primary care professionalsâ views of case finding for depression in patients with diabetes or coronary heart disease in the UK
<p>Background
Routinely conducting case finding (also commonly referred to as screening) in patients with chronic illness for depression in primary care appears to have little impact. We explored the views and experiences of primary care nurses, doctors and managers to understand how the implementation of case finding/screening might impact on its effectiveness.</p>
<p>Methods
Two complementary qualitative focus group studies of primary care professionals including nurses, doctors and managers, in five primary care practices and five Community Health Partnerships, were conducted in Scotland.</p>
<p>Results
We identified several features of the way case finding/screening was implemented that may lead to systematic under-detection of depression. These included obstacles to incorporating case finding/screening into a clinical review consultation; a perception of replacing individualised care with mechanistic assessment, and a disconnection for nurses between management of physical and mental health. Far from being a standardised process that encouraged detection of depression, participants described case finding/screening as being conducted in a way which biased it towards negative responses, and for nurses, it was an uncomfortable task for which they lacked the necessary skills to provide immediate support to patients at the time of diagnosis.</p>
<p>Conclusion
The introduction of case finding/screening for depression into routine chronic illness management is not straightforward. Routinized case finding/screening for depression can be implemented in ways that may be counterproductive to engagement (particularly by nurses), with the mental health needs of patients living with long term conditions. If case finding/screening or engagement with mental health problems is to be promoted, primary care nurses require more training to increase their confidence in raising and dealing with mental health issues and GPs and nurses need to work collectively to develop the relational work required to promote cognitive participation in case finding/screening.</p>
Creating multi-vendor solutions: the resources and capabilities required.
Purpose
â The purpose of this paper is to investigate the resources and capabilities required by manufacturers to develop and deliver multi-vendor solutions.
Design/methodology/approach
â A multi-case design comprising six UK-based manufacturers: two from each of the aerospace/defence, information technology and telecommunications sectors.
Findings
â Manufacturers can be characterized by their propensity to include products from other vendors in their solutions; single vendor solution providers (SVSPs) focus on solutions comprising their own products, while multi-vendor solution providers (MVSPs) fully embrace products from other manufacturers. Three capabilities were identified which distinguish MVSPs from SVSPs given the complexity of multi-vendor solutions (expertise specifying the solution, engineers trained in implementing/supporting the solution, partnerships with component suppliers of the solution). These capabilities are underpinned by both technical capability and impartiality in solution specification.
Research limitations/implications
â MVSPs need to be impartial when specifying customer solutions. They should be guided by the best interests of the customer rather than the interests of the product-based SBUs. Achieving impartiality can conflict with some manufacturers' product heritage. The research has focused on three sectors; further research is needed to test whether the findings are applicable beyond these sectors.
Practical implications
â Solutions are a valuable approach in creating market differentiation, although not all manufacturers will possess the resources/capabilities to be successful.
Originality/value
â A continuum of solution providers is proposed; SVSPs at one extreme and MVSPs at the other. The operant resource-based capability âimpartialityâ was identified as being particularly important to MVSPs in creating value for customers.
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