Meromictic Antarctic lakes as recorders of climate change: the structures of Ace and Organic Lakes, Vestfold Hills, Antarctica

The meromictic lakes that occur in closed, rocky basins of the Vestfold Hills provide records of local climate change. From a consideration of the physical structure of these stratified lakes it is apparent that maximum winter under-ice water salinity (associated with minimum water temperatures) is a function of the water level for a particular lake. The structure of the lakes will also be affected by changes in water balance. An increase in water level will result in a lens of fresher water and warmer winter temperatures at the surface of the lake, whereas a decrease will result in increased salinity, colder temperatures and deeper epilimnetic mixing. Evidence of periods oflow water level is retained by the lakes as intervals of near isopycnal water within the water column, which can be used to calculate minimum palaeolevels. Changes in the structures of Organic Lake and Ace Lake between 1975 and 1995 are used in this article to illustrate these points

The biogeography of shallow-water macrofauna at Heard Island

Collections of 23 macroinvertebrate taxa associated with Durvillaea antarctica holdfasts and 58 invertebrate taxa associated with artificial substrata collectors are described from shallow-water and intertidal habitats at Heard Island. The fauna sampled possessed strong biogeographic affinities with the Kerguelen Island fauna and, to a slightly lesser extent, the fauna recorded at Macquarie Island but negligible affinity with the Antarctic. Experiments involving the offshore tethering of D. antarctica holdfasts indicated that epifaunal invertebrates rapidly abandoned detached holdfasts, but that the few species surviving after one day could probably survive long periods adrift

The history of the elephant seal industry at Macquarie Island and an estimate of the pre-sealing numbers

A comprehensive list was compiled of all sealing ships that visited Macquarie Island (54°30'S, 158°57'E) between 1810 and 1919 and, where possible, their cargoes. Approximately 207 sealing visits were made to Macquarie Island in 109 years and an estimated 8380 tuns of elephant seal oil removed. The major sealing effort seems to have been in the first 20 years, between 1810 and 1829, when almost half of the voyages occurred and over half of the oil was collected. For the present study, a mathematical model was devised to examine the responses of the population to the estimated annual harvest of seals from 1810-29. Given the often incomplete nature of the sealing records, accurate estimates of the pre-sealing elephant seal population were impossible to obtain, but the model suggests that it may have been in the region of 93 000 to 110000 animals. The major impact of sealing activity was between 1820 and 1830, when the population was reduced by approximately 70%. Numbers are thought to have recovered to near pre-sealing levels by the 1900's, when the level of sealing was within the sustainable yield of the population. Key Words: elephant seal, sealing industry, sealing ships, Macquarie Islan

Profound and Sustained Reduction in Chlamydia trachomatis in The Gambia: A Five-Year Longitudinal Study of Trachoma Endemic Communities

Trachoma is the most common infectious cause of blindness worldwide. Mass antibiotic treatment with azithromycin is used to control ocular Chlamydia trachomatis infection. There is uncertainty over how frequently and for how long treatment is needed, particularly in low prevalence settings. This study examines the effect of a single round of treatment on clinical disease and infection in a cluster of trachoma endemic Gambian villages over a five-year period. These villages had good water supplies and sanitation improved part way through the study. We found treatment was followed by a marked decline in infection prevalence (by PCR) to less than 1%. The decline in prevalence of active disease in children was less marked. Several villages had a prevalence of active trachoma in 1 to 9 year old children of greater than 10% during the follow-up period, mostly in the absence of detectable infection. The implication of this study is that a single, high coverage mass treatment may be sufficient to control C. trachomatis infection in a low prevalence setting, particularly when combined with environmental measures to limit transmission. However, relying on clinical signs to guide treatment decisions is likely to lead to significant amounts of over treatment where current guidelines are implemented

Elimination of Active Trachoma after Two Topical Mass Treatments with Azithromycin 1.5% Eye Drops

Trachoma is the leading cause of infectious blindness worldwide, accounting for 1.3 million cases of blindness. Although it has disappeared in many regions of the world, trachoma is still endemic in Africa, Eastern Mediterranean, Latin America, Asia, and Australia. The WHO has currently set a target of 2020 for controlling trachoma to a low enough level that resulting blindness will not be a major public health concern. Topical tetracycline was for a long time the recommended treatment for active trachoma, but compliance to the regimen is extremely poor. Azithromycin has properties that make it an ideal treatment for Chlamydia trachomatis: high efficacy, intracellular accumulation, and a long tissue half-life. There is now a new mass treatment of trachoma by azithromycin 1.5% eye drops which is as effective as the oral route. In the test health district of Kolofata, Cameroon, the prevalence of trachoma among children dramatically decreased from 31% to less than 5% after 2 treatments. A third treatment was performed in January 2010. An epidemiological surveillance is implemented to see if this removal will be permanent. It also avoids misuse of oral azithromycin and the eye drops are directly treating the site of the infection

From regional pulse vaccination to global disease eradication: insights from a mathematical model of Poliomyelitis

Mass-vaccination campaigns are an important strategy in the global fight against poliomyelitis and measles. The large-scale logistics required for these mass immunisation campaigns magnifies the need for research into the effectiveness and optimal deployment of pulse vaccination. In order to better understand this control strategy, we propose a mathematical model accounting for the disease dynamics in connected regions, incorporating seasonality, environmental reservoirs and independent periodic pulse vaccination schedules in each region. The effective reproduction number, $R_e$, is defined and proved to be a global threshold for persistence of the disease. Analytical and numerical calculations show the importance of synchronising the pulse vaccinations in connected regions and the timing of the pulses with respect to the pathogen circulation seasonality. Our results indicate that it may be crucial for mass-vaccination programs, such as national immunisation days, to be synchronised across different regions. In addition, simulations show that a migration imbalance can increase $R_e$ and alter how pulse vaccination should be optimally distributed among the patches, similar to results found with constant-rate vaccination. Furthermore, contrary to the case of constant-rate vaccination, the fraction of environmental transmission affects the value of $R_e$ when pulse vaccination is present.Comment: Added section 6.1, made other revisions, changed titl

The Global Burden of Trachoma: A Review

Trachoma is the commonest infectious cause of blindness worldwide. Recurrent infection of the ocular surface by Chlamydia trachomatis, the causative agent, leads to inturning of the eyelashes (trichiasis) and blinding corneal opacification. Trachoma is endemic in more than 50 countries. It is currently estimated that there are about 1.3 million people blind from the disease and a further 8.2 million have trichiasis. Several estimates for the burden of disease from trachoma have been made, giving quite variable results. The variation is partly because different prevalence data have been used and partly because different sequelae have been included. The most recent estimate from the WHO placed it at around 1.3 million Disability-Adjusted Life Years (DALYs). A key issue in producing a reliable estimate of the global burden of trachoma is the limited amount of reliable survey data from endemic regions

Leisure of family as a pedagogical problem

The pedagogical value of family leisure forms is that they actively involve and intensively use various communication mechanisms: family - children, family - family, children - children, children - teenagers - adults. The simultaneity of these contacts gives the family leisure emotional appeal, sincerity, warmth. Intra-family leisure relationships are already in themselves rehabilitative function, actively influencing the creation of a favorable psychological climate in the family.Педагогическая ценность семейных досуговых форм состоит в том, что в них активно включены и интенсивно задействованы различные механизмы общения: семья - дети, семья - семья, дети - дети, дети - подростки - взрослые. Одновременность этих контактов придает семейному досугу эмоциональную привлекательность, душевность, теплоту. Внутрисемейные досуговые отношения уже сами по себе несут реабилитирующую функцию, активно воздействуют на создание благоприятного психологического климата в семье

The Natural History of Trachoma Infection and Disease in a Gambian Cohort with Frequent Follow-Up

Trachoma is an infectious disease of the eye that causes blindness in many of the poorest parts of the world. In this paper, we use a novel statistical approach to estimate the characteristics of this disease among people living in The Gambia who were examined every 2 weeks over a 6-month period. We found that the typical duration of infection with Chlamydia trachomatis and of clinically active disease were significantly longer than previously estimated. We tested different hypotheses about the natural history of trachoma that explain the relationship between infection and disease observed in the field. We also confirmed that disease lasts significantly longer among young children under 5 years old compared with older children and adults, even after accounting for high rates of re-infection in this age group, consistent with the development of immunity with age. The long duration of infection, especially among younger children, contributes to the persistence and gradual return of trachoma after community-wide treatment with azithromycin. This implies the need for high treatment coverage if infection is to be eliminated from a community, even where the return of infection after treatment is seen to be slow