490 research outputs found
The Next Steps in Our Understanding of GeneâPeer Interplay: A Commentary
The studies included in this special issue on geneâpeer interplay in child and adolescent outcomes can uniformly be described as cutting edge and methodologically sophisticated. When viewed together, they all but conclusively document the presence and importance of geneâpeer interplay in child and adolescent outcomes. Nevertheless, more work on the topic is needed, both because the inherent complexity of peer studies means we know less on this topic than on many others, but also because available research is limited by the descriptive nature of the findings. The current commentary offers suggestions for future work that would begin to remedy these limitations
Commentary: Improving treatment for youth with callousâunemotional traits through the intersection of basic and applied science â reflections on Dadds et al. (2014)
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/107588/1/jcpp12274.pd
Understanding âWhat Could Beâ: A Call for âExperimental Behavioral Geneticsâ
Behavioral genetic (BG) research has yielded many important discoveries about the origins of human behavior, but offers little insight into how we might improve outcomes. We posit that this gap in our knowledge base stems in part from the epidemiologic nature of BG research questions. Namely, BG studies focus on understanding etiology as it currently exists, rather than etiology in environments that could exist but do not as of yet (e.g., etiology following an intervention). Put another way, they focus exclusively on the etiology of âwhat isâ rather than âwhat could beâ. The current paper discusses various aspects of this field-wide methodological reality, and offers a way to overcome it by demonstrating how behavioral geneticists can incorporate an experimental approach into their work. We outline an ongoing study that embeds a randomized intervention within a twin design, connecting âwhat isâ and âwhat could beâ for the first time. We then lay out a more general framework for a new fieldâexperimental BGsâwhich has the potential to advance both scientific inquiry and related philosophical discussions
Using personâspecific neural networks to characterize heterogeneity in eating disorders: Illustrative links between emotional eating and ovarian hormones
ObjectiveEmotional eating has been linked to ovarian hormone functioning, but no studies toâdate have considered the role of brain function. This knowledge gap may stem from methodological challenges: Data are heterogeneous, violating assumptions of homogeneity made by betweenâsubjects analyses. The primary aim of this paper is to describe an innovative withinâsubjects analysis that models heterogeneity and has potential for filling knowledge gaps in eating disorder research. We illustrate its utility in an application to pilot neuroimaging, hormone, and emotional eating data across the menstrual cycle.MethodGroup iterative multiple model estimation (GIMME) is a personâspecific network approach for estimating sampleâ, subgroupâ, and individualâlevel connections between brain regions. To illustrate its potential for eating disorder research, we apply it to pilot data from 10 female twins (Nâ=â5 pairs) discordant for emotional eating and/or anxiety, who provided two resting state fMRI scans and hormone assays. We then demonstrate how the multimodal data can be linked in multilevel models.ResultsGIMME generated personâspecific neural networks that contained connections common across the sample, shared between coâtwins, and unique to individuals. Illustrative analyses revealed positive relations between hormones and default mode connectivity strength for control twins, but no relations for their coâtwins who engage in emotional eating or who had anxiety.DiscussionThis paper showcases the value of personâspecific neuroimaging network analysis and its multimodal associations in the study of heterogeneous biopsychosocial phenomena, such as eating behavior.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/146371/1/eat22902.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/146371/2/eat22902_am.pd
Commentary: Childhood conduct problems are a public health crisis and require resources: a commentary on Rivenbark et al. ()
Black and white 8x10 Acetate Negativehttps://digitalmaine.com/arc_george_french_photos_a810/2202/thumbnail.jp
Introduction: Rethinking the Impact of the Inter-American Human Rights System
This chapter introduces the central themes of the book and argues that the Inter-American Human Rights System (IAHRS) is activated by political actors and institutions in ways that transcend traditional compliance perspectives and that have the potential to meaningfully alter politics and provoke positive domestic human rights change. The chapter identifies key gaps in existing human rights scholarship, particularly in relation to the IAHRS, and outlines three core perspectives on the Systemâs impact on human rights. It offers a synthesis of the key findings of the volume, and provides reflections on the future prospects of the System by locating it in its broader global context
Uncovering the genetic architecture of broad antisocial behavior through a genome-wide association study meta-analysis
Associations between birth size and later height from infancy through adulthood: An individual based pooled analysis of 28 twin cohorts participating in the CODATwins project.
BACKGROUND: There is evidence that birth size is positively associated with height in later life, but it remains unclear whether this is explained by genetic factors or the intrauterine environment. AIM: To analyze the associations of birth weight, length and ponderal index with height from infancy through adulthood within mono- and dizygotic twin pairs, which provides insights into the role of genetic and environmental individual-specific factors. METHODS: This study is based on the data from 28 twin cohorts in 17 countries. The pooled data included 41,852 complete twin pairs (55% monozygotic and 45% same-sex dizygotic) with information on birth weight and a total of 112,409 paired height measurements at ages ranging from 1 to 69âŻyears. Birth length was available for 19,881 complete twin pairs, with a total of 72,692 paired height measurements. The association between birth size and later height was analyzed at both the individual and within-pair level by linear regression analyses. RESULTS: Within twin pairs, regression coefficients showed that a 1-kg increase in birth weight and a 1-cm increase in birth length were associated with 1.14-4.25âŻcm and 0.18-0.90âŻcm taller height, respectively. The magnitude of the associations was generally greater within dizygotic than within monozygotic twin pairs, and this difference between zygosities was more pronounced for birth length. CONCLUSION: Both genetic and individual-specific environmental factors play a role in the association between birth size and later height from infancy to adulthood, with a larger role for genetics in the association with birth length than with birth weight
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