1,488 research outputs found
Dose-adapted post-transplant cyclophosphamide for HLA-haploidentical transplantation in Fanconi anemia.
We developed a haploidentical transplantation protocol with post-transplant cyclophosphamide (CY) for in vivo T-cell depletion (TCD) using a novel adapted-dosing schedule (25 mg/kg on days +3 and +4) for Fanconi anemia (FA). With median follow-up of 3 years (range, 37 days to 6.2 years), all six patients engrafted. Two patients with multiple pre-transplant comorbidities died, one from sepsis and one from sepsis with associated chronic GVHD. Four patients without preexisting comorbidities and early transplant referrals are alive with 100% donor chimerism and excellent performance status. We conclude that adjusted-dosing post-transplant CY is effective in in vivo TCD to promote full donor engraftment in patients with FA
Characteristic Relations for Quantum Matrices
General algebraic properties of the algebras of vector fields over quantum
linear groups and are studied. These quantum algebras
appears to be quite similar to the classical matrix algebra. In particular,
quantum analogues of the characteristic polynomial and characteristic identity
are obtained for them. The -analogues of the Newton relations connecting two
different generating sets of central elements of these algebras (the
determinant-like and the trace-like ones) are derived. This allows one to
express the -determinant of quantized vector fields in terms of their
-traces.Comment: 11 pages, latex, an important reference [16] added
Designing molecules to bypass the singlet-triplet bottleneck in the electroluminescence of organic light-emitting-diode materials
Electroluminescence in organic light emitting diode (OLED) materials occurs
via the recombination of excitonic electrons-hole pairs Only the singlet
excitons of commonly used OLED materials, e.g., Aluminum trihydroxyquinoline
(AlQ), decay radiatively, limiting the external quantum efficiency to a
maximum 25%. Thus 75% of the energy is lost due to the triplet bottleneck for
radiative recombination. We consider molecules derived from AlQ which
bypass the triplet bottleneck by designing structures which contain strong
spin-orbit coupling. As a first stage of this work, groundstate energies and
vertical excitation energies of Al-arsenoquinolines and Al-boroarsenoquinolines
are calculated. It is found that the substitution of N by As leads to very
favourable results, while the boron substitution leads to no advantage.Comment: 4 pages, 4 figue
The potential influence of masculine identity on health-improving behavior in midlife and older African American men
http://dx.doi.org/10.1016/j.jomh.2012.02.00
q-Analogue of
A natural embedding for the
corresponding quantum algebras is constructed through the appropriate
comultiplication on the generators of each of the and
algebras. The above embedding is proved in their -boson realization by means
of the isomorphism between the (mn)(m)(n) algebras.Comment: 11 pages, no figures. In memory of professor R. P. Rousse
A randomized, controlled trial comparing ganciclovir to ganciclovir plus foscarnet (each at half dose) for preemptive therapy of cytomegalovirus infection in transplant recipients
Forty-eight patients who provided 2 consecutive blood samples that tested positive for cytomegalovirus DNA by polymerase chain reaction (PCR) were randomized to receive either full-dose ganciclovir ( 5 mg/kg intravenously [iv] twice daily) or half-dose ganciclovir (5 mg/kg iv once daily) plus half-dose foscarnet (90 mg/kg iv once daily) for 14 days. In the ganciclovir arm, 17 (71%) of 24 patients reached the primary end point of being CMV negative by PCR within 14 days of initiation of therapy, compared with 12 (50%) of 24 patients in the ganciclovir-plus-foscarnet arm (P = .12). Toxicity was greater in the combination-therapy arm. In patients who failed to reach the primary end point, baseline virus load was 0.77 log(10) higher, the replication rate before therapy was faster (1.5 vs. 2.7 days), and the viral decay rate was slower (2.9 vs. 1.1 days) after therapy. Bivariable logistic regression models identified baseline virus load, bone-marrow transplantation, and doubling time and half-life of decay as the major factors affecting response to therapy within 14 days. This study did not support a synergistic effect of ganciclovir plus foscarnet in vivo
The Effect of a Linear Tuning between the Antigenic Stimulations of CD4(+) T Cells and CD4(+) Tregs
We study the equilibria of an Ordinary Differencial Equation (ODE) system where CD4+ effector or helper T cells and Regulatory T cells (Tregs) are present. T cells trigger an immune response in the presence of their specific antigen. Regulatory T cells (Tregs) play a role in limiting auto-immune diseases due to their immune-suppressive ability. Here, we present explicit exact formulas that give the relationship between the concentration of T cells, the concentration of Tregs, and the antigenic stimulation of T cells, when the system is at equilibria, stable or unstable. We found a parameter region of bistability, limited by two thresholds of antigenic stimulation of T cells (hysteresis). Moreover, there are values of the slope parameter of the tuning for which an isola-center bifurcation appears, and, for some other values, there is a transcritical bifurcation. We also present time evolutions of the ODE system
Emerging Issues in the Immunopathogenesis, Diagnosis and Clinical Management of Primary Biliary Cirrhosis Associated with Systemic Sclerosis
Primary Biliary Cirrhosis Associated with Systemic Sclerosis: Diagnostic and Clinical Challenges
Patients with primary biliary cirrhosis (PBC) often have concurrent limited systemic sclerosis (SSc). Conversely, up to one-fourth of SSc patients are positive for PBC-specific antimitochondrial antibodies (AMA). The mechanisms responsible for the co-occurrence of these diseases are largely unknown. Genetic, epigenetic, environmental, and infectious factors appear to be important for the pathogenesis of the disease, but the hierarchy of events are not well defined. Patients with SSc and PBC have an increased morbidity and mortality compared with the general population, but whether the presence of both diseases in an affected individual worsens the prognosis and/or outcome of either disease is not clear. Some case reports suggested that the presence of SSc in PBC patents is associated with a more favorable prognosis of the liver disease, whereas others report an increased mortality in patients with PBC and SSc compared to patients with PBC alone. This paper discusses the features of patients with PBC-associated SSc. Our aims are to clarify some of the pathogenetic, diagnostic, and clinical challenges that are currently faced in the routine management of these patients. We also intend to provide some practical hints for practitioners that will assist in the early identification of patients with PBC-associated SSc
Spectral extension of the quantum group cotangent bundle
The structure of a cotangent bundle is investigated for quantum linear groups
GLq(n) and SLq(n). Using a q-version of the Cayley-Hamilton theorem we
construct an extension of the algebra of differential operators on SLq(n)
(otherwise called the Heisenberg double) by spectral values of the matrix of
right invariant vector fields. We consider two applications for the spectral
extension. First, we describe the extended Heisenberg double in terms of a new
set of generators -- the Weyl partners of the spectral variables. Calculating
defining relations in terms of these generators allows us to derive SLq(n) type
dynamical R-matrices in a surprisingly simple way. Second, we calculate an
evolution operator for the model of q-deformed isotropic top introduced by
A.Alekseev and L.Faddeev. The evolution operator is not uniquely defined and we
present two possible expressions for it. The first one is a Riemann theta
function in the spectral variables. The second one is an almost free motion
evolution operator in terms of logarithms of the spectral variables. Relation
between the two operators is given by a modular functional equation for Riemann
theta function.Comment: 38 pages, no figure
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