Manipulator technology for the space shuttle

A shuttle-attached manipulator is currently proposed as the payload-handling device for the space shuttle. Basic requirements for the manipulator involve length, force, compliance, and control. Approaches for studying control methods are presented and simulation methods are discussed. Basic details about the two earthbased manipulators selected for simulation experiments are related to the test methods. Preliminary data from one test are shown as an example of the direction of the testing. A computer-generated simulation is explained, and the relationship of the three simulations to the design problems is discussed

Evaluating the effectiveness of entrepreneurial leadership coaching

Peer reviewedFinal Accepted Versio

An Analysis of Profits within the Canadian Food Processing Sector

Agribusiness,

Liver transplantation

Purpose of review: Long-term survival of liver transplant recipients is threatened by increased rates of de-novo malignancy and recurrence of hepatocellular carcinoma (HCC), both events tightly related to immunosuppression. Recent findings: There is accumulating evidence linking increased exposure to immunosuppressants and carcinogenesis, particularly concerning calcineurin inhibitors (CNIs), azathioprine and antilymphocyte agents. A recent study including 219 HCC transplanted patients showed that HCC recurrence rates were halved if a minimization of CNIs was applied within the first month after liver transplant. With mammalian target of rapamycin (mTOR) inhibitors as approved immunosuppressants for liver transplant patients, pooled data from several retrospective studies have suggested their possible benefit for reducing HCC recurrence. Summary: Randomized controlled trials with sufficiently long follow-up are needed to evaluate the influence of different immunosuppression protocols in preventing malignancy after LT. Currently, early minimization of CNIs with or without mTOR inhibitors or mycophenolate seems a rational strategy for patients with risk factors for de-novo malignancy or recurrence of HCC after liver transplant. A deeper understanding of the immunological pathways of rejection and cancer would allow for designing more specific and safer drugs, and thus to prevent cancer after liver transplant

Human cytomegalovirus (HCMV) replication dynamics in HCMV-naive and -experienced immunocompromised hosts

Human cytomegalovirus (HCMV) can infect both HCMV-naive and -experienced transplant patients. In this study, the growth rate of HCMV in HCMV-naive hosts (1.82 units/day; 95% confidence interval [CI], 1.44-2.56 units/day) was shown to be significantly faster than the growth rate of virus in HCMV-experienced hosts undergoing recurrent infection (0.61 units/ day; 95% CI, 0.55-0.7 units/day; P93% (95% CI, 89%-98%) is required to eliminate viral growth during infection of HCMV-naive liver transplant recipients, whereas lower efficacy levels are sufficient to reduce the R-0 value to <1 in hosts with prior HCMV immunity

‘The Nautical Melodrama of Mary Barton’

In hisMemoirs of anUnfortunate Son of Thespis (1818), the actor Edward Cape Everard recalled a performance of Sheridan's School for Scandal that was interrupted in its third act by a rowdy bunch of sailors. At the sight of Charles Surface drinking, the sailors allegedly left the auditorium, entered the stage, and accosted the actor playing Charles, “exclaiming ‘My eyes, you're a hearty fellow! Come, my tight one, hand us a glass’” (qtd. in Russell 104). As apocryphal as the encounter seems, it is not the only account of mariners rushing the early-nineteenth century stage to join in with the drama. In her analysis of these anecdotes Gillian Russell comments that though they may have been intended to depict the sailor “as naïve and unsophisticated, unable to make the distinction between fiction and reality. . . it is not surprising that the sailor should have disregarded the rules of mimesis and the distinction between stage and auditorium” (104), for the sailor's life lent itself to, and was structured by, theatricality. Service in “the theatres of war,” or more generally in the “wooden world” of the ship, demanded strict performance of custom and ritual in the forging of social identities and relations, not least of all in the ritualistic initiation ceremonies and corporal punishments that were enacted in front of the amassed audience of the crew (Russell 139–57; see Dening). At sea and in dock sailors entertained themselves with amateur theatricals. On shore, they were keen theatre-goers, and in auditoriums and elsewhere they played up to the characteristics of the sailor in the brazen assertion of an identity that was celebrated in stories, songs, and plays, but frequently also belittled, bemoaned, and victimized, the latter particularly while the press gangs were active

I'm streaming of a white Christmas

A presentation outlining the use of Kaltura Streaming Video tool at Canterbury Christ Church University