Impacts of cyberbullying

With the recent change in technology, bullying has taken on a new form called cyberbullying. Due to how new cyberbullying is, parents and educators may be unaware of what it is and how it takes place. There are many different forms of cyberbullying that can take place twenty-four hours a day, seven days week. Cyberbullying can take place at schools and at home while leaving an everlasting impact on an individual. This paper will discuss what cyberbullying is and the different forms it can take on. It will also address how students spend their time on the internet and why parents should be concerned. Finally this paper will discuss how cyberbullying is a problem and what parents and educators can do to address this problem together

Specific Delivery of Therapeutics to Cancer Cells Using pHLIP

Localized delivery is vital for the successful development of novel and effective therapeutics for the treatment of cancer. Currently, most targeting methods are based on cancer markers, such as cell surface receptors. However, this approach suffers from two major drawbacks: biomarkers are not specific to cancer cells, which can result in off-target toxicity, and cancer cells have a tendency to evolve quickly, which can lead to a loss of biomarkers, thus therapy resistance. However, nearly all solid tumors have a low extracellular pH, regardless of their tissue or cellular origin. Moreover, tumors\u27 aggressiveness and metastatic potential are fostered at low extracellular pH. For these reasons, acidosis is a hallmark of tumor progression and may provide an opportunity for tumor-targeted therapy.The targeting and delivery described herein is based on the pH(Low) Insertion Peptide (pHLIP), a unique delivery peptide that can selectively target tumors in mice based solely on their acidity rather than a specific marker. pHLIP is a soluble peptide in aqueous solutions at normal pH, but inserts unidirectionally (C-terminus across) into cell membrane as a transmembrane helix under acidic conditions. My thesis research focused on developing new strategies to inhibit cancer cell growth by delivering therapeutics to cells using pHLIP. We hypothesize that the localized targeting achievable with pHLIP when combined with potent therapeutics will synergize to create an advantageous treatment for cancer. I will present my results in (1) inhibiting cancer cell proliferation and tumor through the delivery of monomethyl auristatin derivatives, (2) modulating the activity of G-Protein coupled receptors by interfering with their cytoplasmic domains, and (3) promoting cancer cells toxicity by inducing mitochondrial membrane disruption through the delivery of antimicrobial peptide analogs

“A Tale of Two Hospitals”: The Role of Place-Based Sensemaking in COVID-19 Communication for Rural and Urban Texas Hospitals

Rural and urban hospitals must respond differently to crises such as the COVID-19 pandemic, given their unique situations. In this study, we performed a rhetorical analysis of press releases from rural and urban hospitals in Texas to better understand the crisis communication strategies of the two hospital systems. Following previous literature on narrative sensemaking, place-based storytelling, and pre-crisis management, we found that the examined press releases used setting details to ground their health-related information in their specific communities. Such a strategy made the information accessible and attainable, but potentially reinforced place-based tensions and inequalities. Our study has implications for preventative sensemaking research as well as for crisis communicators attempting to better reach specific communities during a long-term, developing crisis

Regional Human Rights Regimes: A Comparison and Appraisal

For Americans at least, active concern for human rights on the international plane is demonstrated perhaps most conspicuously in the promotion and protection of human rights through the United Nations and its allied agencies--apart, that is, from the promotion and protection of human rights through United States foreign policy and the work of such nongovernmental organizations as Amnesty International. Supplementing this globally-oriented human rights activity, however, are international human rights regimes operating regionally in Western Europe, the Americas, Africa and the Middle East. Concededly, Asia is not yet represented, and only the first three of the represented regions have gone so far as to create enforcement mechanisms within the framework of a human rights charter, as evidenced by the European Convention for the Protection of Human Rights and Fundamental Freedoms and the European Social Charter, the American Convention on Human Rights and the Banjul (African) Charter on Human and Peoples\u27 Rights. The Permanent Arab Commission on Human Rights, founded by the Council of the League of Arab States in September 1968 but since then understandably preoccupied by the rights of Palestinian Arabs in and to the Israeli-occupied territories, has yet to bring a proposed Arab Convention on Human Rights to successful conclusion, and so far has tended to function more in terms of the promotion than the protection of human rights. Nevertheless, the regional development of human rights norms, institutions and procedures is likely to grow. Already an important dynamic of international human rights law and policy, it is, in any event, here to stay

Behavior Change Techniques Present in Wearable Activity Trackers: A Critical Analysis

Please cite as: Mercer K, Li M, Giangregorio L, Burns C, Grindrod K Behavior Change Techniques Present in Wearable Activity Trackers: A Critical Analysis JMIR Mhealth Uhealth 2016;4(2):e40 DOI: 10.2196/mhealth.4461 PMID: 27122452 PMCID: 4917727Background: Wearable activity trackers are promising as interventions that offer guidance and support for increasing physical activity and health-focused tracking. Most adults do not meet their recommended daily activity guidelines, and wearable fitness trackers are increasingly cited as having great potential to improve the physical activity levels of adults. Objective: The objective of this study was to use the Coventry, Aberdeen, and London-Refined (CALO-RE) taxonomy to examine if the design of wearable activity trackers incorporates behavior change techniques (BCTs). A secondary objective was to critically analyze whether the BCTs present relate to known drivers of behavior change, such as self-efficacy, with the intention of extending applicability to older adults in addition to the overall population. Methods: Wearing each device for a period of 1 week, two independent raters used CALO-RE taxonomy to code the BCTs of the seven wearable activity trackers available in Canada as of March 2014. These included Fitbit Flex, Misfit Shine, Withings Pulse, Jawbone UP24, Spark Activity Tracker by SparkPeople, Nike+ FuelBand SE, and Polar Loop. We calculated interrater reliability using Cohen's kappa. Results: The average number of BCTs identified was 16.3/40. Withings Pulse had the highest number of BCTs and Misfit Shine had the lowest. Most techniques centered around self-monitoring and self-regulation, all of which have been associated with improved physical activity in older adults. Techniques related to planning and providing instructions were scarce. Conclusions: Overall, wearable activity trackers contain several BCTs that have been shown to increase physical activity in older adults. Although more research and development must be done to fully understand the potential of wearables as health interventions, the current wearable trackers offer significant potential with regard to BCTs relevant to uptake by all populations, including older adults

Case Studies of Emerging/Innovative Vocational Rehabilitation Agency Practices in Improving Employment Outcomes for Individuals with Intellectual/Developmental Disabilities

The Vocational Rehabilitation Research and Training Center (VR-RRTC.org) based at the Institute for Community Inclusion (ICI) at the University of Massachusetts Boston partnered with national content experts to identify promising VR employment practices serving people with intellectual and/or developmental disabilities (IDD). The National Institute on Disability and Rehabilitation Research (NIDRR), the funding agency,requested an emphasis on identifying promising practices for people with mental illnesses and peoplewith intellectual disabilities/developmental disabilities, and to identify promising practices related to order of selection and the designation of most significant disability. This report provides a summary of four promising VR employment practices for persons with IDD. The study included a nationwide call for nominations through extensive outreach using a variety of channels and venues, including (but not limited to) direct contact with VR agencies, Technical Assistance and Continuing Education (TACE) Centers, the Council of State Administrators of Vocational Rehabilitation (CSAVR), the Rehabilitation Services Administration (RSA), and NIDRR. The VR RRTC formed a Delphi expert panel to review and rateall nominated practices using a systematic, multi-step procedure to evaluate nominations

A comparative study of the songs of William Denis Browne

Composer William Denis Browne died at the age of 26 in World War I. The executor of his musical estate, Edward J. Dent, prevented many of his compositions from being performed or published in the years following his death. Because of these unfortunate circumstances, Browne’s songs fell into relative obscurity and are now under-represented in both scholarship and performance. However, they are deserving of more attention. Browne composed in several genres during his short lifetime, but his nine extant songs represent more than half of his surviving output. Musicians and scholars should be aware of the existence of these songs and their historical context. This study familiarizes scholars, singers, collaborative pianists, and teachers of voice with his extant songs through documentary research into Browne’s life, an introduction to the poets whose texts he chose to set, and a comparative study of each song’s musical score, their setting of the texts, and their pedagogic value. This document examines the poems, their poets, and the musical settings of the nine songs Browne composed between 1908 and 1914. For the musical settings, attention is paid to musical forms, harmony, rhythm, vocal articulation, vocal ranges, piano accompaniments, overall effectiveness, and singer accessibility. These songs represent the full range of Browne’s compositional abilities in the art song genre. Aspects of Browne’s relationships with Edward J. Dent, Rupert Brooke, Edward Marsh, and other important historic figures illuminate the reality in which Browne lived and the circumstances under which he composed this handful of songs. His musical settings blend quality poetry and music. The songs, though small in number, illustrate Browne’s maturation into a composer whose songs deserve to be placed at the center of the British art song canon. Knowledge and understanding of his life from his youth until his death allows performers to convey a sensitive and informed expression necessary to bring his songs to life

A Team Observed Structured Clinical Encounter (TOSCE) for Pre-Licensure Learners in Maternity Care: A Short Report on the Development of an Assessment Tool for Collaboration

Background: Despite the support for Interprofessional Education (IPE) among policymakers, educators and professional regulating bodies, the research literature is limited with respect to the evaluation of effective assessment strategies. This short report outlines the development of a Team Observed Structured Clinical Encounter (TOSCE), which brings together learners from three health professions involved in primary care obstetrics-family physicians, midwives, and obstetricians-as a strategy for assessing collaborative competencies.Methods: An interprofessional research team was brought together to develop and implement the TOSCE. The process by which the team generated TOSCE scenario stations is outlined, including the consensus-building process, based on a modified Delphi technique, to include expert input from others in the field of practice.Findings: The scenarios developed by the research team for the TOSCE are highlighted including the assessment criteria, based on the Canadian InterprofessionalHealth Collaborative's National Competency Framework.Conclusions: The TOSCE is an emerging and innovative learning tool that encourages the development of essential collaborative competencies. The process of developing a TOSCE outlined in this report offers an affordable, streamlined approach that could be used by educators in many disciplines as a summative or formative assessment strategy