Photochemical Functionalization of Helicenes

Herein, a visible-light photochemical approach for practical helicene functionalization at very mild reaction conditions is described. The photochemical reactions allow for the regiospecific and innate late-stage functionalization of helicenes and are easily executed either through the activation of C(sp(2))-Br bonds in helicenes using K2CO3 as inorganic base or direct C(sp(2))-H helicene bond functionalization under oxidative photoredox reaction conditions. Overall, using these transformations six different functional groups are introduced to the helicene scaffold through C-C and four different C-heteroatom bond-forming reactions

The Danger Within: Insider Threat Modeling Using Business Process Models

Threat modeling has been successfully applied to model technical threats within information systems. However, a lack of methods focusing on non-technical assets and their representation can be observed in theory and practice. Following the voices of industry practitioners, this paper explored how to model insider threats based on business process models. Hence, this study developed a novel insider threat knowledge base and a threat modeling application that leverages Business Process Modeling and Notation (BPMN). Finally, to understand how well the theoretic knowledge and its prototype translate into practice, the study conducted a real-world case study of an IT provider's business process and an experimental deployment for a real voting process. The results indicate that even without annotation, BPMN diagrams can be leveraged to automatically identify insider threats in an organization

Model for the Pattern-Dependent Wet Grip Prediction of Tires

The most important task of the tire is to ensure driving safety by optimally transmitting the required longitudinal and lateral driving forces. Although great progress has been made in the past in the development of new materials and patterns, many questions remain unanswered in the field of elastomer friction on rough surfaces. This is particularly true when an additional intermediate medium is introduced into the contact, as for braking on wet roads in the form of water. To better understand this process, a model of a single-tread block on a rough road surface is developed. The influence of the fluid is represented by a physical meaningful friction law. The model is validated with results of tire wet-braking tests on an internal drum test rig. The model can map the interaction between tire tread, rough road surface and fluid film and the simulation results show a good agreement with the measurement results. Based on the investigation of individual tread blocks, a new approach to the description of the wet-braking behavior of passenger car tires was thus demonstrated, which can be extended to more complex tread geometries in the future

Growth/climate response shift in a long subalpine spruce chronology

A new Norway spruce (Picea abies (L.) Karst.) tree-ring width chronology based on living and historic wood spanning the AD 1108-2003 period is developed. This composite record combines 208 high elevation samples from 3 Swiss subalpine valleys, i.e., Lötschental, Goms, and Engadine. To retain potential high- to low-frequency information in this dataset, individual spline detrending and the regional curve standardization are applied. For comparison, 22 high elevation and 6 low-elevation instrumental station records covering the greater Alpine area are used. Previous year August-September precipitation and current year May-July temperatures control spruce ring width back to ∼1930. Decreasing (increasing) moving correlations with monthly mean temperatures (precipitation) indicate instable growth/climate response during the 1760-2002 period. Crucial June-August temperatures before ∼1900 shift towards May-July temperature plus August precipitation sensitivity after ∼1900. Numerous of comparable subalpine spruce chronologies confirm increased late-summer drought stress, coincidently with the recent warming trend. Comparison with regional-, and large-scale millennial-long temperature reconstructions reveal significant similarities prior to ∼1900 (1300-1900 mean r=0.51); however, this study does not fully capture the commonly reported 20th century warming (1900-1980 mean r=−0.17). Due to instable growth/climate response of the new spruce chronology, further dendroclimatic reconstruction is not performe

Hemodynamic effects of partial liquid ventilation with perfluorocarbon in acute lung injury

Objective: To assess the effect of partial liquid ventilation with perfluorocarbons on hemodynamics and gas exchange in large pigs with induced acute lung injury (ALI). Design: Randomized, prospective, double-control, experimental study. Setting: Experimental intensive care unit of a university. Materials: Eighteen large pigs (50±5 kg body weight) with an average anterior posterior thoracic diameter of 24 cm and induced acute lung injury. Interventions: All animals were surfactant depleted by lung lavage to a PaO2 below 100 mmHg and randomized to receive either perflubron (n=6) or saline (n=6) in five intratracheal doses of 5 ml/kg at 20-min intervals, or no instillation (n=6). Measurements and results: In all animals heart rate, arterial pressures, pulmonary pressures, cardiac output and blood gases were recorded at 20-min intervals. There was no deleterious effect on any hemodynamic parameter in the perflubron group, whereas systolic and mean pulmonary arterial pressure values showed a persistent decrease after the first 5 ml/kg of perflubron, from 48.7±14.1 to 40.8±11.7 mmHg and from 39.7±13.2 to 35.2±12.0 mmHg, respectively. Perflubron resulted in a significant (ANOVA P<0.01), dose-dependent increase in PaO2 values from 86.3±22.4 to a maximum of 342.4±59.4 mmHg at a dose of 25 ml/kg; the other groups showed no significant increase in PaO2. Conclusions: Tracheal instillation of perflubron in induced ALI results in a dose-dependent increase in PaO2 and has no deleterious effect on hemodynamic parameters