Governance of the world food system and crisis prevention

The present study offers a framework, rooted in Disaster Studies. The next few sections will first discuss the analytical tool box, which we have largely drawn from Disaster Studies. Thereafter the food regime will be looked into in the quantitative (food security, Section 3.1) and qualitative sense (food safety, Section 3.2), and the actors and rules and regulations for international food aid discussed. It will become clear that the private sector has a key role to play in both categories. Chapter 4 calls attention to the increasing complexities and uncertainties in the global food system that complicate food governance. To get anything done at all, a simplification seems necessary, such as declaring a food problem a safety issue

Membranes fabricated with a deep single corrugation for package stress reduction and residual stress relief

Thin square membranes including a deep circular corrugation are realized and tested for application in a strain-based pressure sensor. Package-induced stresses are reduced and relief of the residual stress is obtained, resulting in a large pressure sensitivity and a reduced temperature sensitivity. Finite element method simulations were carried out, showing that the pressure-deflection behaviour of the structure is close to that of a circular membrane with clamped edge but free radial motion

Sex physiology of pigs

The articles have been scanned in colour with a HP Scanjet 5590; 300dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format

Transcutaneous vagus nerve stimulation and extinction of prepared fear: A conceptual non-replication

Stress-related psychiatric disorders across the life spa

Further Developments on a Vibration-Free Helium-Hydrogen Sorption Cooler

In our continuous effort on the development of a passively precooled two-stage 4.5 K / 14.5 K helium-hydrogen sorption cooler, a number of important development steps were made. Firstly, an improved high-density activated carbon was used for the fabrication of four new sorption cells. Tests with these new cells showed that because of increased efficiency, the required passive radiator area for this cooler reduced by a factor of 1.3. Secondly, it was shown that this cooler architecture can easily be used to reach lower (or higher) temperatures. Without hardware changes, the cold temperature was reduced from 4.5 K to 3.1 K. Thirdly, long-term experiments were carried out on the cooler. In two separate periods of two and four months of continuous operation, no change at all was observed in the cooler performance. Fourthly, clogging effects were analyzed that occurred after a 15 months storage period of the cooler at 300 K. We concluded that hydrogen diffusion out of the stainless steel components should be prevented. Finally, a design of an integrated compact cooler chain was presented, which consists of a 50 K Stirling cooler and the helium-hydrogen sorption cooler. This package may be used in the future to test the sorption cooler technology in a zero-gravity environment

Cohesin mutations alter DNA damage repair and chromatin structure and create therapeutic vulnerabilities in MDS/AML

The cohesin complex plays an essential role in chromosome maintenance and transcriptional regulation. Recurrent somatic mutations in the cohesin complex are frequent genetic drivers in cancer including myelodysplatic syndromes (MDS) and acute myeloid leukemia (AML). Here, using genetic dependency screens of STAG2-mutant AML, we identified DNA damage repair and replication as genetic dependencies in cohesin-mutant cells. We demonstrated increased levels of DNA damage and sensitivity of cohesin-mutant cells to PARP inhibition. We developed a mouse model of MDS in which Stag2 mutations arise as clonal secondary lesions in the background of clonal hematopoiesis driven by Tet2 mutations, and demonstrated selective depletion of cohesin-mutant cells with PARP inhibition in vivo. Finally, we demonstrated a shift from STAG2- to STAG1-containing cohesin complexes in cohesin-mutant cells, which is associated with longer DNA loop extrusion, more intermixing of chromatin compartments, and increased interaction with PARP and RPA proteins. Our findings inform the biology and therapeutic opportunities for cohesin-mutant malignancies