The Iowa Homemaker vol.26, no.4

Metamorphosis, Lorraine Midlang, page 2 Keeping Up With Today, page 3 A Letter Home, page 4 Pinned, Engaged, or Going Steady?, Ruth Walker, page 5 Changing College to Five Years, Betsy Nichols and Jean Bunge, page 6 Mothers Operate Nursery School, Carol Bureck Best, page 8 New Hope for Space Shortage, Nancy Baker, page 9 What’s New in Home Economics, Marjorie Clampitt, page 10 Vicky Introduces S.W.O.C., Margery Saunders, page 13 A Cookbook You Can’t Put Down, Charlene Stettler, page 15 Back Stage Performance, Elizabeth Adams, page 16 “Send For” Pamphlets Make Fingertip Files, page 18 Graduate Designs Greeting Cards, Carita Girton, page 19 ’46 Speaks, Alumnae, page 2

Entwicklung eines visuellen modellgetriebenen Transformationsframeworks für QVT

In dieser Diplomarbeit wird die Entwicklung eines Frameworks beschrieben, welches das visuelle Definieren von Modelltransformationen in der Sprache Query/View/Transformation Relations (QVT/R) zwischen EMF Metamodellen erlaubt. Die Sprache ist Teil des Standards Meta Object Facility (MOF) 2.0 Query/View/Transformation, v1.0, der vom Industriekonsortium Object Management Group (OMG) beschlossen wurde und Teil der OMG Initiative Model Driven Architecture ist, die Technologien und Vorgehen für die Modellgetriebene Softwareentwicklung standardisiert. Die QVT/R-Sprachpezifikation umfasst die abstrakte sowie die konkrete textuelle und konkrete visuelle Syntax. Im Rahmen der Arbeit wurde die konkrete visuelle Syntax implementiert und eine Synchronisation mit der textuellen Syntax umgesetz t. Die Implementierung erlaubt darüber hinaus das Verknüpfen von Elementen der graphischen Syntax mit Trace-Daten, welche von QVT/REngines generiert wurden. Die Entwicklung selbst wurde mit Modellgetriebenen Technologien durchgeführt. Die technische Basis bilden das Eclipse Framework und dessen Unterprojekte EMF und GMF. Für die Synchronisation zwischen Modell und Text kam die Medini QVT Engine und das openArchitectureWare Framework zum Einsatz

The Iowa Homemaker vol.26, no.4

Metamorphosis, Lorraine Midlang, page 2 Keeping Up With Today, page 3 A Letter Home, page 4 Pinned, Engaged, or Going Steady?, Ruth Walker, page 5 Changing College to Five Years, Betsy Nichols and Jean Bunge, page 6 Mothers Operate Nursery School, Carol Bureck Best, page 8 New Hope for Space Shortage, Nancy Baker, page 9 What’s New in Home Economics, Marjorie Clampitt, page 10 Vicky Introduces S.W.O.C., Margery Saunders, page 13 A Cookbook You Can’t Put Down, Charlene Stettler, page 15 Back Stage Performance, Elizabeth Adams, page 16 “Send For” Pamphlets Make Fingertip Files, page 18 Graduate Designs Greeting Cards, Carita Girton, page 19 ’46 Speaks, Alumnae, page 20</p

Ventricular arrhythmia in heart failure patients with reduced ejection fraction and central sleep apnoea

Cheyne-Stokes respiration (CSR) may trigger ventricular arrhythmia in patients with heart failure with reduced ejection fraction (HFrEF) and central sleep apnoea (CSA). This study determined the prevalence and predictors of a high nocturnal ventricular arrhythmia burden in patients with HFrEF and CSA (with and without CSR) and to evaluate the temporal association between CSR and the ventricular arrhythmia burden. This cross-sectional ancillary analysis included 239 participants from the SERVE-HF major sub-study who had HFrEF and CSA, and nocturnal ECG from polysomnography. CSR was stratified in >= 20% and 30 premature ventricular complexes (PVCs) per hour of TRT. A sub-analysis was performed to evaluate the temporal association between CSR and ventricular arrhythmias in sleep stage N2. High ventricular arrhythmia burden was observed in 44% of patients. In multivariate logistic regression analysis, male sex, lower systolic blood pressure, non-use of antiarrhythmic medication and CSR.20% were significantly associated with PVCs >30.h(-1) (OR 5.49, 95% CI 1.51-19.91, p=0.010; OR 0.98, 95% CI 0.97-1.00, p=0.017; OR 5.02, 95% CI 1.51- 19.91, p=0.001; and OR 2.22, 95% CI 1.22-4.05, p=0.009; respectively). PVCs occurred more frequently during sleep phases with versus without CSR (median (interquartile range): 64.6 (24.8-145.7) versus 34.6 (4.8-75.2).h(-1) N2 sleep; p=0.006). Further mechanistic studies and arrhythmia analysis of major randomised trials evaluating the effect of treating CSR on ventricular arrhythmia burden and arrhythmia-related outcomes are warranted to understand how these data match with the results of the parent SERVE-HF study

Ventricular arrhythmia in heart failure patients with reduced ejection fraction and central sleep apnoea

Cheyne–Stokes respiration (CSR) may trigger ventricular arrhythmia in patients with heart failure with reduced ejection fraction (HFrEF) and central sleep apnoea (CSA). This study determined the prevalence and predictors of a high nocturnal ventricular arrhythmia burden in patients with HFrEF and CSA (with and without CSR) and to evaluate the temporal association between CSR and the ventricular arrhythmia burden.  This cross-sectional ancillary analysis included 239 participants from the SERVE-HF major sub-study who had HFrEF and CSA, and nocturnal ECG from polysomnography. CSR was stratified in ≥20% and 30 premature ventricular complexes (PVCs) per hour of TRT. A sub-analysis was performed to evaluate the temporal association between CSR and ventricular arrhythmias in sleep stage N2.  High ventricular arrhythmia burden was observed in 44% of patients. In multivariate logistic regression analysis, male sex, lower systolic blood pressure, non-use of antiarrhythmic medication and CSR ≥20% were significantly associated with PVCs >30·h−1 (OR 5.49, 95% CI 1.51–19.91, p=0.010; OR 0.98, 95% CI 0.97–1.00, p=0.017; OR 5.02, 95% CI 1.51–19.91, p=0.001; and OR 2.22, 95% CI 1.22–4.05, p=0.009; respectively). PVCs occurred more frequently during sleep phases with versus without CSR (median (interquartile range): 64.6 (24.8–145.7) versus 34.6 (4.8–75.2)·h−1 N2 sleep; p=0.006).  Further mechanistic studies and arrhythmia analysis of major randomised trials evaluating the effect of treating CSR on ventricular arrhythmia burden and arrhythmia-related outcomes are warranted to understand how these data match with the results of the parent SERVE-HF study

Effects of Adaptive Servo-Ventilation on Nocturnal Ventricular Arrhythmia in Heart Failure Patients With Reduced Ejection Fraction and Central Sleep Apnea-An Analysis From the SERVE-HF Major Substudy

Background: The SERVE-HF trial investigated the effect of treating central sleep apnoea (CSA) with adaptive servo-ventilation (ASV) in patients with heart failure with reduced ejection fraction (HFrEF). Objective: The aim of the present ancillary analysis of the SERVE-HF major substudy (NCT01164592) was to assess the effects of ASV on the burden of nocturnal ventricular arrhythmias as one possible mechanism for sudden cardiac death in ASV-treated patients with HFrEF and CSA. Methods: Three hundred twelve patients were randomized in the SERVE-HF major substudy [no treatment of CSA (control) vs. ASV]. Polysomnography including nocturnal ECG fulfilling technical requirements was performed at baseline, and at 3 and 12 months. Premature ventricular complexes (events/h of total recording time) and non-sustained ventricular tachycardia were assessed. Linear mixed models and generalized linear mixed models were used to analyse differences between the control and ASV groups, and changes over time. Results: From baseline to 3- and 12-month follow-up, respectively, the number of premature ventricular complexes (control: median 19.7, 19.0 and 19.0; ASV: 29.1, 29.0 and 26.0 events/h; p = 0.800) and the occurrence of ≥1 non-sustained ventricular tachycardia/night (control: 18, 25, and 18% of patients; ASV: 24, 16, and 24% of patients; p = 0.095) were similar in the control and ASV groups. Conclusion: Addition of ASV to guideline-based medical management had no significant effect on nocturnal ventricular ectopy or tachyarrhythmia over a period of 12 months in alive patients with HFrEF and CSA. Findings do not further support the hypothesis that ASV may lead to sudden cardiac death by triggering ventricular tachyarrhythmia