Circuit and plasticity defects in the developing somatosensory cortex of FMR1 knock-out mice

Silencing of the Fmr1 gene causes fragile X syndrome. Although defects in synaptic plasticity in the cerebral cortex have been linked to cognitive impairments in Fmr1 knock-out (ko) mice, the specific cortical circuits affected in the syndrome are unknown. Here, we investigated the development of excitatory projections in the barrel cortex of Fmr1 ko mice. In 2-week-old Fmr1 ko mice, a major ascending projection connecting layer 4 (L4) to L3 (L4-->L3), was defective in multiple and independent ways: its strength was reduced, caused by a lower connection probability; the axonal arbors of L4 cells were spatially diffuse in L2/3; the L4-->L3 projection did not show experience-dependent plasticity. By 3 weeks, the strength of the L4-->L3 projection was similar to that of wild type. Our data indicate that Fmr1 shapes sensory cortical circuits during a developmental critical period

The algebraic and Hamiltonian structure of the dispersionless Benney and Toda hierarchies

The algebraic and Hamiltonian structures of the multicomponent dispersionless Benney and Toda hierarchies are studied. This is achieved by using a modified set of variables for which there is a symmetry between the basic fields. This symmetry enables formulae normally given implicitly in terms of residues, such as conserved charges and fluxes, to be calculated explicitly. As a corollary of these results the equivalence of the Benney and Toda hierarchies is established. It is further shown that such quantities may be expressed in terms of generalized hypergeometric functions, the simplest example involving Legendre polynomials. These results are then extended to systems derived from a rational Lax function and a logarithmic function. Various reductions are also studied.Comment: 29 pages, LaTe

A Better Definition of the Kilogram

This article reviews several recent proposed redefinitions of the kilogram, and compares them with respect to practical realizations, uncertainties (estimated standard deviations), and educational aspects.Comment: 10 pages, no figure

Stellar kinematics in double-barred galaxies: the sigma-hollows

We present SAURON integral-field stellar velocity and velocity dispersion maps for four double-barred early-type galaxies: NGC2859, NGC3941, NGC4725 and NGC5850. The presence of the inner bar does not produce major changes in the line-of-sight velocity, but it appears to have an important effect in the stellar velocity dispersion maps: we find two sigma-hollows of amplitudes between 10 and 40 km/s on either side of the center, at the ends of the inner bars. We have performed numerical simulations to explain these features. Ruling out other possibilities, we conclude that the sigma-hollows are an effect of the contrast between two kinematically different components: the high velocity dispersion of the bulge and the more ordered motion (low velocity dispersion) of the inner bar.Comment: 5 pages, 2 figures. Accepted for publication in ApJ Letter

Classification of integrable two-component Hamiltonian systems of hydrodynamic type in 2+1 dimensions

Hamiltonian systems of hydrodynamic type occur in a wide range of applications including fluid dynamics, the Whitham averaging procedure and the theory of Frobenius manifolds. In 1+1 dimensions, the requirement of the integrability of such systems by the generalised hodograph transform implies that integrable Hamiltonians depend on a certain number of arbitrary functions of two variables. On the contrary, in 2+1 dimensions the requirement of the integrability by the method of hydrodynamic reductions, which is a natural analogue of the generalised hodograph transform in higher dimensions, leads to finite-dimensional moduli spaces of integrable Hamiltonians. In this paper we classify integrable two-component Hamiltonian systems of hydrodynamic type for all existing classes of differential-geometric Poisson brackets in 2D, establishing a parametrisation of integrable Hamiltonians via elliptic/hypergeometric functions. Our approach is based on the Godunov-type representation of Hamiltonian systems, and utilises a novel construction of Godunov's systems in terms of generalised hypergeometric functions.Comment: Latex, 34 page

Boxy/peanut/X bulges, barlenses and the thick part of galactic bars: What are they and how did they form?

Bars have a complex three-dimensional shape. In particular their inner part is vertically much thicker than the parts further out. Viewed edge-on, the thick part of the bar is what is commonly known as a boxy-, peanut- or X- bulge and viewed face-on it is referred to as a barlens. These components are due to disc and bar instabilities and are composed of disc material. I review here their formation, evolution and dynamics, using simulations, orbital structure theory and comparisons to observations.Comment: 21 pages, 7 figures, invited review to appear in "Galactic Bulges", E. Laurikainen, R. Peletier, D. Gadotti, (eds.), Springe

Coalition theories: empirical evidence for dutch municipalities

The paper analyzes coalition formation in Dutch municipalities. After discussing the main features of the institutional setting, several theories are discussed, which are classified as size oriented, policy oriented and actor oriented models. A test statistic is proposed to determine the predictive power of these models. The empirical analysis shows that strategic positions as well as some of the distinguished preferences are important in the setting of Dutch municipalities. Especially, the dominant minimum number principle yields highly significant results for coalition formations in the period 1978–1986

Star formation and figure rotation in the early-type galaxy NGC2974

We present Galaxy Evolution Explorer (GALEX) far (FUV) and near (NUV) ultraviolet imaging of the nearby early-type galaxy NGC2974, along with complementary ground-based optical imaging. In the ultraviolet, the galaxy reveals a central spheroid-like component and a newly discovered complete outer ring of radius 6.2kpc, with suggestions of another partial ring at an even larger radius. Blue FUV-NUV and UV-optical colours are observed in the centre of the galaxy and from the outer ring outward, suggesting young stellar populations (< 1Gyr) and recent star formation in both locations. This is supported by a simple stellar population model which assumes two bursts of star formation, allowing us to constrain the age, mass fraction and surface mass density of the young component pixel by pixel. Overall, the mass fraction of the young component appears to be just under 1per cent (lower limit, uncorrected for dust extinction). The additional presence of a nuclear and an inner ring (radii 1.4 and 2.9kpc, respectively), as traced by [OIII] emission, suggests ring formation through resonances. All three rings are consistent with a single pattern speed of $78\pm6$ km/s/kpc, typical of S0 galaxies and only marginally slower than expected for a fast bar if traced by a small observed surface brightness plateau. This thus suggests that star formation and morphological evolution in NGC2974 at the present epoch are primarily driven by a rotating asymmetry (probably a large-scale bar), despite the standard classification of NGC2974 as an E4 elliptical.Comment: 13 pages, 10 figures, Changed content, Accepted for publication in MNRA

A SAURON study of stars and gas in Sa bulges

We present results from our ongoing effort to understand the morphological and kinematical properties of early-type galaxies using the integral-field spectrograph SAURON. We discuss the relation between the stellar and gas morphology and kinematics in our sub-sample of 24 representative Sa spiral bulges. We focus on the frequency of kinematically decoupled components and on the presence of star formation in circumnuclear rings.Comment: 6 pages, 3 figures; To appear in the proceedings of the "Island Universes: Structure and Evolution of Disk Galaxies" conference held in Terschelling, Netherlands, July 2005, ed. R. de Jong. A high resolution version is available at http://www.strw.leidenuniv.nl/~jfalcon/JFB_terschelling.pdf.g

Environment, Ram Pressure, and Shell Formation in HoII

Neutral hydrogen VLA D-array observations of the dwarf irregular galaxy HoII, a prototype galaxy for studies of shell formation, are presented. HI is detected to radii over 16' or 4 R_25, and M_HI=6.44x10^8 M_sun. The total HI map has a comet-like appearance suggesting that HoII is affected by ram pressure from an intragroup medium (IGM). A rotation curve corrected for asymmetric drift was derived and an analysis of the mass distribution yields a total mass 6.3x10^9 M_sun, of which about 80% is dark. HoII lies northeast of the M81 group's core, along with Kar52 (M81dwA) and UGC4483. No signs of interaction are observed and it is argued that HoII is part of the NGC2403 subgroup, infalling towards M81. A case is made for ram pressure stripping and an IGM in the M81 group. Stripping of the disk outer parts would require an IGM density n_IGM>=4.0x10^-6 atoms/cm^3 at the location of HoII. This corresponds to 1% of the virial mass of the group uniformly distributed over a volume just enclosing HoII and is consistent with the X-ray properties of small groups. It is argued that existing observations of HoII do not support self-propagating star formation scenarios, whereby the HI holes and shells are created by supernova explosions and stellar winds. Many HI holes are located in low surface density regions of the disk, where no star formation is expected or observed. Ram pressure has the capacity to enlarge preexisting holes and lower their creation energies, helping to bridge the gap between the observed star formation rate and that required to create the holes. (abridged)Comment: 43 pages, including 7 figures. 4 figures available as JPEG only. Complete manuscript including full resolution figures available at http://www.strw.leidenuniv.nl/~bureau/pub_list.html . Accepted for publication in The Astronomical Journa