156 research outputs found

    THE FAILURE OF REMEDIAL JUSTICE

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    Corn, 2006

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    William J. Wiebold is a Professor of Plant Sciences and State Extension Specialist; Howard L. Mason is a Senior Research Specialist; Delbert Knerr, Ri chard W. Hasty, David M. Schwab, and Scotty L. Smothers are Research Specialists; Travis Belt is a Research Associate in Plant Sciences and Bruce Burdick is the Superintendent of the Hundl ey-Whaley Research Center.Compares hybrids and includes experimental procedures, seed corn characteristics and seed corn company addresses

    Inhibition of Amyloid-β Aggregation and Caspase-3 Activation by the \u3ci\u3eGinkgo biloba\u3c/i\u3e Extract EGb761

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    Standardized extract from the leaves of the Ginkgo biloba tree, labeled EGb761, has been used in clinical trials for its beneficial effects on brain functions, particularly in connection with age-related dementias and Alzheimer\u27s disease (AD). Substantial experimental evidence indicates that EGb761 protects against neuronal damage from a variety of insults, but its cellular and molecular mechanisms remain unknown. Using a neuroblastoma cell line stably expressing an AD-associated double mutation, we report that EGb761 inhibits formation of amyloid-β (Aβ) fibrils, which are the diagnostic, and possibly causative, feature of AD. The decreased Aβ fibrillogenesis in the presence of EGb761 was observed both in the conditioned medium of this Aβ-secreting cell line and in solution in vitro. In the cells, EGb761 significantly attenuated mitochondrion-initiated apoptosis and decreased the activity of caspase 3, a key enzyme in the apoptosis cell-signaling cascade. These results suggest that (i) neuronal damage in AD might be due to two factors: a direct Aβ toxicity and the apoptosis initiated by the mitochondria; and (ii) multiple cellular and molecular neuroprotective mechanisms, including attenuation of apoptosis and direct inhibition of Aβ aggregation, underlie the neuroprotective effects of EGb761

    Corn, 2005

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    William J. Wiebold is a Professor of Plant Sciences and State Extension Specialist; Howard L. Mason is a Senior Research Specialist; Delbert Knerr, Richard W. Hasty, Eddie G. Adams, David M. Schwab, and Scotty L. Smothers are Research Specialists; Travis Belt is a Research Associate in Plant Sciences and Bruce Burdick is the Superintendent of the Hundley-Whaley Research Center.Compares hybrids and includes experimental procedures, seed corn characteristics and seed corn company addresses

    Ernst Freund as Precursor of the Rational Study of Corporate Law

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    Gindis, David, Ernst Freund as Precursor of the Rational Study of Corporate Law (October 27, 2017). Journal of Institutional Economics, Forthcoming. Available at SSRN: https://ssrn.com/abstract=2905547, doi: https://dx.doi.org/10.2139/ssrn.2905547The rise of large business corporations in the late 19th century compelled many American observers to admit that the nature of the corporation had yet to be understood. Published in this context, Ernst Freund's little-known The Legal Nature of Corporations (1897) was an original attempt to come to terms with a new legal and economic reality. But it can also be described, to paraphrase Oliver Wendell Holmes, as the earliest example of the rational study of corporate law. The paper shows that Freund had the intuitions of an institutional economist, and engaged in what today would be called comparative institutional analysis. Remarkably, his argument that the corporate form secures property against insider defection and against outsiders anticipated recent work on entity shielding and capital lock-in, and can be read as an early contribution to what today would be called the theory of the firm.Peer reviewe

    Cryogenic Optical Performance of a Lightweighted Mirror Assembly for Future Space Astronomical Telescopes: Correlating Optical Test Results and Thermal Optical Model

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    A 43cm diameter stacked core mirror demonstrator was interferometrically tested at room temperature down to 250 degrees Kelvin for thermal deformation. The 2.5m radius of curvature spherical mirror assembly was constructed by low temperature fusing three abrasive waterjet core sections between two CNC pocket milled face sheets. The 93% lightweighted Corning ULE mirror assembly represents the current state of the art for future UV, optical, near IR space telescopes. During the multiple thermal test cycles, test results of interferometric test, thermal IR images of the front face were recorded in order to validate thermal optical model
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