407 research outputs found
Here Goes Nothing: Creating The Role Of Timothy Allgood In Noises Off.
Noises Off is the epitome of farce. Doors everywhere, mistaken identities, and unrequited love. The characters push themselves to the limit, both mentally and physically. They stop at nothing to put on their production and their stage manager, Timothy Allgood, becomes the babysitter of the group, which at times becomes comparable to herding cats.
This document describes the journey made from casting to final bows. It contains biographical research on the playwright, Michael Frayn, as well as a historical look at the genre of farce, techniques pioneered by Sanford Meisner and Konstantin Stanislavski, along with materials, including a scored script, character analysis, personal evaluation, and rehearsal reflections
Seabrook: A Case Study in Mismanagement
The Seabrook nuclear power plant construction project is an unqualified financial disaster. It simultaneously threatens its chief owner, the Public Service Co. of New Hampshire (PSNH) with bankruptcy and the company\u27s electricity customers with huge rate increases. The fifteen-year history of the project is reviewed to identify what went wrong?
The review suggests that the basic problem has been mismanagement by both PSNH and by government regulators. A three-year regulatory imbroglio over the environmental effects of the plant\u27s cooling system was extremely costly in the mid-1970s.
By the time this problem was belatedly resolved, the project had begun to outstrip the financial resources of its owners. These resources were seriously weakened by a political battle over how to pay for construction costs.
By the end of the 1970s, the risks of proceeding with Seabrook were beginning to exceed the benefits. PSNH management, however, chose to accept these risks, in effect betting their company that the project could be completed.
Underlying many of Seabrook\u27s problems are certain federal nuclear regulatory policies and practices whose roots go all the way back to the Eisenhower administration. These policies are also briefly reviewed
Here Goes Nothing: Creating The Role Of Timothy Allgood In Noises Off.
Noises Off is the epitome of farce. Doors everywhere, mistaken identities, and unrequited love. The characters push themselves to the limit, both mentally and physically. They stop at nothing to put on their production and their stage manager, Timothy Allgood, becomes the babysitter of the group, which at times becomes comparable to herding cats.
This document describes the journey made from casting to final bows. It contains biographical research on the playwright, Michael Frayn, as well as a historical look at the genre of farce, techniques pioneered by Sanford Meisner and Konstantin Stanislavski, along with materials, including a scored script, character analysis, personal evaluation, and rehearsal reflections
Antiphospholipid Antibody Syndrome Causing Progressive Central Nervous System Dysfunction in a Young Patient
Analysis of the Intracellular Transport Properties of Recombinant La Crosse Virus Glycoproteins
AbstractThe G1 and G2 glycoproteins of La Crosse virus, a member of theBunyavirusgenus of the Bunyaviridae, are encoded as a single open reading frame (ORF) in the viral middle-sized RNA segment. The primary product from this ORF is processed, either cotranslationally or shortly after translation, into the two glycoproteins and a nonstructural protein, NSm, of unknown function. We have expressed La Crosse glycoproteins using vaccinia vectors and studied their processing and localization. When expressed in the native G2-NSm-G1 configuration, both G1 and G2 targeted to the Golgi apparatus as shown by their colocalization with wheat germ agglutinin and acquired resistance to endoglycosidase H. When expressed independently, G2 was targeted to the Golgi apparatus but G1 was retained in the endoplasmic reticulum, indicating that a G1âG2 association is required for Golgi targeting of G1. In contrast to results with other members of the Bunyaviridae, we found that expression of G1 and G2 from separate vectors did not lead to the transport of the G1âG2 complex to the Golgi. However, disruption of the NSm region with a foreign sequence did not interfere with transport of the complex. When a portion of the ÎČ-galactosidase gene was inserted in frame into NSm, the glycoproteins derived from this construct were processed and targeted properly and were capable of mediating cell-to-cell fusion
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John Lydgate and His Readers
Fifteenth-century poet John Lydgate holds the distinction of being both prolific and popular in his own time. Unfortunate comparisons to his literary forbear, Geoffrey Chaucer, dampened his early reputation, and Lydgate spent centuries out of favor with literary critics. In the past decade, he has enjoyed a resurgence of critical attention; this project considers why this may be and also why he remained in the critical shadows for so long. To answer these questions, I turn to Lydgateâs approach to his readers and the manuscripts and early printed books with which his early (and enthusiastic) audience would have been encountering his works. This project argues that Lydgateâs encouragement of readers to participate in the work, to correct him where they find fault, is sincere. He undertakes a system of literary creation that deliberately does not enforce a hierarchical approach to authority; instead of literary authority remaining with the poet, Lydgate attempts to bestow it upon those among his readers who would prudently and earnestly correct his work. In examining the manuscripts and early printed books of the works, I am able to determine those places where communication between Lydgate, the bookmakers, and the readers concerning this issue were most visible, and most able to elicit readerly interactions
EXPERIMENTAL IMPLEMENTATION OF INTEGRATOR BACKSTEPPING AND PASSIVE NONLINEAR CONTROLLERS ON THE RTAC TESTBED
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/57811/1/BenchmarkIJRNCBuppIJRNC1998.pd
A BENCHMARK PROBLEM FOR NONLINEAR CONTROL DESIGN
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/57785/1/BenchmarkIJRNCproblemIJRNC1998.pd
Finite Settling Time Control of the Double Integrator Using a Virtual Trap-Door Absorber
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/57813/1/TrapDoorTAC2000.pd
Telomere anchoring at the nuclear periphery requires the budding yeast Sad1-UNC-84 domain protein Mps3
Positioning of telomeres at the nuclear periphery can have dramatic effects on gene expression by establishment of heritable, transcriptionally repressive subdomains. However, little is known about the integral membrane proteins that mediate telomere tethering at the nuclear envelope. Here, we find a previously unrecognized function for the Saccharomyces cerevisiae Sad1-UNC-84 domain protein Mps3 in regulating telomere positioning in mitotic cells. Our data demonstrate that the nucleoplasmic N-terminal acidic domain of Mps3 is not essential for viability. However, this acidic domain is necessary and sufficient for telomere tethering during S phase and the silencing of reporter constructs integrated at telomeres. We show that this is caused by the role of the Mps3 acidic domain in binding and localization of the silent information regulator protein Sir4 to the nuclear periphery. Thus, Mps3 functions as an integral membrane anchor for telomeres and is a novel nuclear receptor for the Sir4 pathway of telomere tethering and gene inactivation
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