226 research outputs found
The perceived impact of social support received from coaches of injured college athletes
Includes bibliographical references
Welcome to the European Union: Visit to Moria first reception centre, Moria, nr. Mytilini, Lesvos, Greece 11th May 2014
In April 2013 we visited the âopenâ Pikpa camp that was provided by the municipality and run by volunteers on the Greek island of Lesvos. Just over a year later, on Sunday 11th May 2014, we went in search of the new âclosedâdetention centre. We were to find that in addition to the current temporary detention âcampâ which we hoped to visit, the EU is funding the building of a new expanded detention centre, the Moria First Reception Camp, and it was to this we were directed by Greek friends
Identification of acid reflux cough using serial assays of exhaled breath condensate pH
BACKGROUND: Chronic cough is a common problem, frequently caused or exacerbated by acid reflux. Diagnosis of acid reflux cough is haphazard currently, often relying on long therapeutic trials of expensive medications. We tested the hypothesis that the most relevant mechanistic component of acid reflux in chronic cough is when it rises to the level of the airway where acid can potentially be aspirated. We further wished to determine if multi-sample exhaled breath condensate (EBC) pH profiles can identify chronic cough patients likely to respond to proton pump inhibitor therapy. METHODS: 59 subjects were recruited for this study. Initially we examined EBC pH (gas-standardized with Argon) in the setting of 15 experimental pharyngeal acid challenges to determine duration of EBC acidification. Subsequently, we enrolled 22 healthy subjects to determine a normal multi-sample exhaled breath condensate pH profile over 1â3 days. We additionally obtained multi-sample EBC pH profiles in 22 patients with chronic cough. These samples were timed to occur after coughing episodes. Exhaled breath condensate pH was measured after gas standardization. RESULTS: We found that exhaled breath condensate pH is substantially reduced for approximately 15 minutes after pharyngeal acid load. Healthy subjects rarely have any low EBC pH values (defined as < 7.4 based on a normative reference range from 404 healthy subjects). Patients with chronic cough who subsequently responded well to proton pump inhibition (n = 8) invariably had one or more cough episodes associated with EBC acidification. No patient who had normal EBC pH with each of their cough episodes reported a clinically relevant response to proton-pump inhibition. CONCLUSION: Patients whose cough responds to proton pump inhibition have transient exhaled breath condensate acidification with coughing episodes, supporting the role of airway acidification in reflux-triggered cough. Multi-sample EBC pH profiles, involving samples collected immediately subsequent to a coughing episode, may be useful appropriately to direct therapy to those patients with cough who have relevant acid reflux
Traka yon kretyen pandan vwayaj li : adaptasyon liv âPilgrimâs Progress" / John Bunyan
91 pages : illustrations ; 22 c
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