632 research outputs found
Extrapolations of Lattice Meson Form Factors
We use chiral perturbation theory to study the extrapolations necessary to
make physical predictions from lattice QCD data for the electromagnetic form
factors of pseudoscalar mesons. We focus on the quark mass, momentum, lattice
spacing, and volume dependence and apply our results to simulations employing
mixed actions of Ginsparg-Wilson valence quarks and staggered sea quarks. To
determine charge radii at quark masses on the lattices currently used, we find
that all extrapolations except the one to infinite volume make significant
contributions to the systematic error.Comment: 14pp, discussion and Ref. added for disconnected diagram
Molecular profiling of multiplexed gene markers to assess viability of ex vivo human colon explant cultures
© Janice E. Drew et al. 2015; Published by Mary Ann Liebert, Inc. This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. Acknowledgments The authors would like to thank the patients who kindly donated tissue samples, Sally Chalmers of the Tayside Tissue Bank for her help with collecting of the tissue donor samples, Emma Moss for advice on human colon dissection and explant culture, and Claus Dieter Mayer, Biomathematics and Statistics Scotland, for advice on statistical analysis. This work was supported by the Scottish Government (GT403), Scottish Universities Life Science Alliance, and TENOVUS Scotland.Peer reviewedPublisher PD
An HI absorption distance to the black hole candidate X-ray binary MAXI J1535-571
With the Australian Square Kilometre Array Pathfinder (ASKAP) we monitored
the black hole candidate X-ray binary MAXI J1535--571 over seven epochs from 21
September to 2 October 2017. Using ASKAP observations, we studied the HI
absorption spectrum from gas clouds along the line-of-sight and thereby
constrained the distance to the source. The maximum negative radial velocities
measured from the HI absorption spectra for MAXI J1535--571 and an
extragalactic source in the same field of view are km s and
km s, respectively. This rules out the far kinematic distance
( kpc), giving a most likely distance of
kpc, with a strong upper limit of the tangent point at kpc.
At our preferred distance, the peak unabsorbed luminosity of MAXI J1535--571
was per cent of the Eddington luminosity, and shows that the soft-to-hard
spectral state transition occurred at the very low luminosity of 1.2 -- 3.4
10 times the Eddington luminosity. Finally, this study
highlights the capabilities of new wide-field radio telescopes to probe
Galactic transient outbursts, by allowing us to observe both a target source
and a background comparison source in a single telescope pointing.Comment: Revised after favorable referee report from MNRAS Letter
The UTMOST: A hybrid digital signal processor transforms the MOST
The Molonglo Observatory Synthesis Telescope (MOST) is an 18,000 square meter
radio telescope situated some 40 km from the city of Canberra, Australia. Its
operating band (820-850 MHz) is now partly allocated to mobile phone
communications, making radio astronomy challenging. We describe how the
deployment of new digital receivers (RX boxes), Field Programmable Gate Array
(FPGA) based filterbanks and server-class computers equipped with 43 GPUs
(Graphics Processing Units) has transformed MOST into a versatile new
instrument (the UTMOST) for studying the dynamic radio sky on millisecond
timescales, ideal for work on pulsars and Fast Radio Bursts (FRBs). The
filterbanks, servers and their high-speed, low-latency network form part of a
hybrid solution to the observatory's signal processing requirements. The
emphasis on software and commodity off-the-shelf hardware has enabled rapid
deployment through the re-use of proven 'software backends' for its signal
processing. The new receivers have ten times the bandwidth of the original MOST
and double the sampling of the line feed, which doubles the field of view. The
UTMOST can simultaneously excise interference, make maps, coherently dedisperse
pulsars, and perform real-time searches of coherent fan beams for dispersed
single pulses. Although system performance is still sub-optimal, a pulsar
timing and FRB search programme has commenced and the first UTMOST maps have
been made. The telescope operates as a robotic facility, deciding how to
efficiently target pulsars and how long to stay on source, via feedback from
real-time pulsar folding. The regular timing of over 300 pulsars has resulted
in the discovery of 7 pulsar glitches and 3 FRBs. The UTMOST demonstrates that
if sufficient signal processing can be applied to the voltage streams it is
possible to perform innovative radio science in hostile radio frequency
environments.Comment: 12 pages, 6 figure
The Commensal Real-time ASKAP Fast Transients (CRAFT) survey
We are developing a purely commensal survey experiment for fast (<5s)
transient radio sources. Short-timescale transients are associated with the
most energetic and brightest single events in the Universe. Our objective is to
cover the enormous volume of transients parameter space made available by
ASKAP, with an unprecedented combination of sensitivity and field of view. Fast
timescale transients open new vistas on the physics of high brightness
temperature emission, extreme states of matter and the physics of strong
gravitational fields. In addition, the detection of extragalactic objects
affords us an entirely new and extremely sensitive probe on the huge reservoir
of baryons present in the IGM. We outline here our approach to the considerable
challenge involved in detecting fast transients, particularly the development
of hardware fast enough to dedisperse and search the ASKAP data stream at or
near real-time rates. Through CRAFT, ASKAP will provide the testbed of many of
the key technologies and survey modes proposed for high time resolution science
with the SKA.Comment: accepted for publication in PAS
A new layout optimization technique for interferometric arrays, applied to the MWA
Antenna layout is an important design consideration for radio interferometers
because it determines the quality of the snapshot point spread function (PSF,
or array beam). This is particularly true for experiments targeting the 21 cm
Epoch of Reionization signal as the quality of the foreground subtraction
depends directly on the spatial dynamic range and thus the smoothness of the
baseline distribution. Nearly all sites have constraints on where antennas can
be placed---even at the remote Australian location of the MWA (Murchison
Widefield Array) there are rock outcrops, flood zones, heritages areas,
emergency runways and trees. These exclusion areas can introduce spatial
structure into the baseline distribution that enhance the PSF sidelobes and
reduce the angular dynamic range. In this paper we present a new method of
constrained antenna placement that reduces the spatial structure in the
baseline distribution. This method not only outperforms random placement
algorithms that avoid exclusion zones, but surprisingly outperforms random
placement algorithms without constraints to provide what we believe are the
smoothest constrained baseline distributions developed to date. We use our new
algorithm to determine antenna placements for the originally planned MWA, and
present the antenna locations, baseline distribution, and snapshot PSF for this
array choice.Comment: 12 pages, 6 figures, 1 table. Accepted for publication in MNRA
Interferometric imaging with the 32 element Murchison Wide-field Array
The Murchison Wide-field Array (MWA) is a low frequency radio telescope,
currently under construction, intended to search for the spectral signature of
the epoch of re-ionisation (EOR) and to probe the structure of the solar
corona. Sited in Western Australia, the full MWA will comprise 8192 dipoles
grouped into 512 tiles, and be capable of imaging the sky south of 40 degree
declination, from 80 MHz to 300 MHz with an instantaneous field of view that is
tens of degrees wide and a resolution of a few arcminutes. A 32-station
prototype of the MWA has been recently commissioned and a set of observations
taken that exercise the whole acquisition and processing pipeline. We present
Stokes I, Q, and U images from two ~4 hour integrations of a field 20 degrees
wide centered on Pictoris A. These images demonstrate the capacity and
stability of a real-time calibration and imaging technique employing the
weighted addition of warped snapshots to counter extreme wide field imaging
distortions.Comment: Accepted for publication in PASP. This is the draft before journal
typesetting corrections and proofs so does contain formatting and journal
style errors, also has with lower quality figures for space requirement
Some Like it Hot: The X-Ray Emission of The Giant Star YY Mensae
(Abridged abstract) We present an analysis of the X-ray emission of the
rapidly rotating giant star YY Mensae observed by Chandra HETGS and XMM-Newton.
Although no obvious flare was detected, the X-ray luminosity changed by a
factor of two between the XMM-Newton and Chandra observations taken 4 months
apart. The coronal abundances and the emission measure distribution have been
derived from three different methods using optically thin collisional
ionization equilibrium models. The abundances show an inverse first ionization
potential (FIP) effect. We further find a high N abundance which we interpret
as a signature of material processed in the CNO cycle. The corona is dominated
by a very high temperature (20-40 MK) plasma, which places YY Men among the
magnetically active stars with the hottest coronae. Lower temperature plasma
also coexists, albeit with much lower emission measure. Line broadening is
reported, which we interpret as Doppler thermal broadening, although rotational
broadening due to X-ray emitting material high above the surface could be
present as well. We use two different formalisms to discuss the shape of the
emission measure distribution. The first one infers the properties of coronal
loops, whereas the second formalism uses flares as a statistical ensemble. We
find that most of the loops in the corona of YY Men have their maximum
temperature equal to or slightly larger than about 30 MK. We also find that
small flares could contribute significantly to the coronal heating in YY Men.
Although there is no evidence of flare variability in the X-ray light curves,
we argue that YY Men's distance and X-ray brightness does not allow us to
detect flares with peak luminosities Lx <= 10^{31} erg/s with current
detectors.Comment: Accepted paper to appear in Astrophysical Journal, issue Nov 10, 2004
(v615). This a revised version. Small typos are corrected. Figure 7 and its
caption and some related text in Sct 7.2 are changed, without incidence for
the conclusion
Application of pharmacogenomics and bioinformatics to exemplify the utility of human <i>ex vivo</i> organoculture models in the field of precision medicine
Here we describe a collaboration between industry, the National Health Service (NHS) and academia that sought to demonstrate how early understanding of both pharmacology and genomics can improve strategies for the development of precision medicines. Diseased tissue ethically acquired from patients suffering from chronic obstructive pulmonary disease (COPD), was used to investigate inter-patient variability in drug efficacy using ex vivo organocultures of fresh lung tissue as the test system. The reduction in inflammatory cytokines in the presence of various test drugs was used as the measure of drug efficacy and the individual patient responses were then matched against genotype and microRNA profiles in an attempt to identify unique predictors of drug responsiveness. Our findings suggest that genetic variation in CYP2E1 and SMAD3 genes may partly explain the observed variation in drug response
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