Alien Registration- Bunting, Elsie K. (Kittery, York County)

https://digitalmaine.com/alien_docs/3658/thumbnail.jp

White coat hypertension is associated with increased small vessel disease in the brain

Objective: Small vessel disease, as measured by white matter hyperintensity (WMH) in the brain, is known to be associated with increased stroke risk and cognitive impairment. This study explored the relationship between WMH on computerised tomography (CT) and white coat hypertension/effect (WCH/E) in patients with recent transient ischaemic attack (TIA) or lacunar stroke (LS). Design and method: Ninety-six patients recruited for the ASIST trial (Arterial Stiffness in Lacunar Stroke and TIA) underwent measurement of clinic blood pressure (BP) and ambulatory BP monitoring (APBM) within two weeks of TIA or LS. Twenty-three patients had normotension (clinic BP / = 140/90mmHg and day-time ABPM < 135/85mmHg). Arterial stiffness was measured using carotid-femoral pulse wave velocity (PWV) (Complior®, ALAM Medical) and carotid-ankle vascular index (CAVI) (VaSera VS-1500N®, Fukuda Denshi). CT images were scored for WMH using the four-point Fazekas visual rating scale. Patients were grouped into no-mild WMH (scores 0–1) or moderate-severe (scores 2–3) groups. The relationship between BP, vascular stiffness and WMH was explored with t-tests, chi-square and logistic regression accounting for known cardiovascular risk factors. Results: Forty-four percent of patients with WCH/E had moderate-severe WMH compared to 17% of normotensives (p = 0.047). The regression model with WMH as the dependent factor, and WCH/E and cardiovascular risk factors as independent factors showed WCH/E and either CAVI or PWV to be the only independent significant factor contributing to WMH (CAVI:p = 0.038, PWV:p = 0.043)

P104 White coat hypertension is associated with increased small vessel disease in the brain

Objective: Small vessel disease, measured by brain white matter hyperintensity (WMH), is associated with increased stroke risk and cognitive impairment. This study aimed to explore the relationship between WMH on computerised tomography (CT) and white coat hypertension (WCH) in patients with recent transient ischaemic attack (TIA) or lacunar stroke (LS). Methods: Ninety-six patients recruited for the ASIST trial (Arterial Stiffness in Lacunar Stroke and TIA) underwent measurement of clinic blood pressure (BP) and ambulatory BP monitoring (APBM) within two weeks of TIA or LS. Patients were grouped by BP phenotypes. Twenty-three patients had normotension (clinic BP 140/90 mmHg and day-time ABPM <135/85 mmHg). CT brain images were scored for WMH using the four-point Fazekas visual rating scale. Patients were grouped into no-mild WMH (scores 0–1) or moderate-severe (scores 2–3) groups. The relationship between BP and WMH was explored with chi-square and logistic regression accounting for known cardiovascular risk factors (age, gender, smoking, diabetes and hyperlipidaemia). Results: 44% of WCH patients had moderate-severe WMH compared to 17% of normotensives (p = 0.047). Logistical regression incorporating WCH as the independent factor and cardiovascular risk factors as independent variables showed WCH to be the only independent significant factor contributing to WMH (p = 0.024). Conclusion: Patients with WCH were more likely to have moderate-severe WMH on CT brain than normotensives. WCH was associated with increased WMH, independent of other cardiovascular risk factors. This study suggests that WCH is associated with increased small vessel disease in the brain and may benefit from treatment

“Authorship prevails in nurseries”: Alice Meynell, Mother/Mentor/Muse

Viola Meynell was raised in an at-home magazine office and trained in aestheticist poetry of the 1890s by her mother, Alice Meynell. Making use of extensive and previously unpublished correspondence between Alice and Viola from the Meynell family archive, this essay charts Viola’s rebellious turn towards the novel form and early experimental modernism, and her rebellion’s impact on the mother-daughter relationship. The two women wrote about each other in myriad poetry, essays, fiction, and biography, and, when read side by side, these writings offer an intriguing picture of their lives together and trace alternating periods of generational distance and intimacy. Specifically, the article traces Alice’s reification in print as ideal wife, mother, and homemaker, and contrasts this ideal with Viola’s daily observations of her mother. Before and after Alice’s death, Viola fought to demythologize, reclaim, celebrate, and mourn the real Alice Meynell in her work, while her own literary reputation was damaged by her association with the domestic and her prolonged apprenticeship under her mother

“Thank God for the Public Press, Which Sheds Its Strong White Light on All the Dark Corners of the Earth!”: Ada Nield Chew’s Journey From Factory Girl To Author-Activist

ABSTRACT: This essay recovers an often overlooked episode in women’s labor history. Its focus on author-activist Ada Nield Chew reconstructs her journey towards literary professionalization and her evolving relation to literature and the radical press. The essay features extended close literary analysis of Nield’s “Crewe Factory Girl” letters for the first time. Examining their significance as historical records contextualizes Nield’s early writings and their intersections with the literary marketplace, socialism, and feminism in 1890s England

‘Feelings of Vivid Fellowship’: Vernon Lee and Clementina Anstruther-Thomson’s Quest for Collaborative ‘Aesthetic Sociability’

The article provides an analysis of the shared life writing of Vernon Lee and Clementina Anstruther-Thomson, with particular reference to the writing of ‘Beauty and Ugliness’. The essay investigates how the authors’ already precarious subjectivities as women working in the male-dominated scientific and aesthetic fields of the 1890s were brought under further stress by Lee’s compulsive need for increased strength through union with another, her scepticism about her own abilities as ‘motor-type’ aesthete, and the collaborators’ unequal investigative and textual methodology. By analysing Lee’s semi-autobiographical depictions of her work with Anstruther-Thomson in Althea and focusing in particular on the pair’s one successful experiment in the search for ‘aesthetic sociability’ in front of Titian’s ‘Sacred and Profane Love’, this essay charts the development of their shared lives and writing from their first meeting, to the ecstatic pinnacle of their joint achievement, before examining the collapse of their collaborative dyad

Ada Nield Chew: England’s forgotten suffragist

An open access essay on Ada Nield Chew, author, activist, suffragist, examining her work and her legacy, published in this popular online Magazine, an extension of the BBC History Magazine