PROTECCIÓN ESTATAL DEL PATRIMONIO CULTURAL, ANÁLISIS DEL ESTADO ACTUAL DE LA CONVENCIÓN “Sobre las medidas que deben adoptarse para prohibir la importación, exportación y la transferencia de propiedad ilícita de bienes culturales 1970”

Desde los primeros tratados luego de la posguerra, en la segunda mitad del siglo pasado, que tendían a proteger los bienes arquitectónicos, patrimonio tangible e intangible, surge la convención sobre las medidas que deben adoptarse para prohibir la importación, exportación y la transferencia de propiedad ilícita de bienes culturales del año 1970, que trataremos aquí, nos relacionaremos con el mundo de tráfico, específicamente de objetos. Objetos de gran valor cultural para una nación que se encuentran desarraigados ilegalmente en otra nación

Historical Newspaper User Interfaces: A Review

After decades of large-scale digitization, many historical newspaper collections are just one click away via online portals developed and supported by various public or private stakeholders. Initially offering access to full text search and facsimiles visualization only, historic newspaper user interfaces are increasingly integrating advanced exploration features based on the application of text mining tools to digitized sources. As gateways to enriched material, such interfaces are however not neutral and play a fundamental role in how users perceive historical sources, understand potential biases of upstream processes and benefit from the opportunities of datafication. What features can be found in current interfaces, and to what degree do interfaces adopt novel technologies? This paper presents a survey of interfaces for digitized historical newspapers with the aim of mapping the current state of the art and identifying recent trends with regard to content presentation, enrichment and user interaction. We devised 6 interface assessment criteria and reviewed twenty-four interfaces based on ca. 140 predefined features

Impresso Inspect and Compare. Visual Comparison of Semantically Enriched Historical Newspaper Articles

The automated enrichment of mass-digitised document collections using techniques such as text mining is becoming increasingly popular. Enriched collections offer new opportunities for interface design to allow data-driven and visualisation-based search, exploration and interpretation. Most such interfaces integrate close and distant reading and represent semantic, spatial, social or temporal relations, but often lack contrastive views. Inspect and Compare (I\&C) contributes to the current state of the art in interface design for historical newspapers with highly versatile side-by-side comparisons of query results and curated article sets based on metadata and semantic enrichments. I\&C takes search queries and pre-curated article sets as inputs and allows comparisons based on the distributions of newspaper titles, publication dates and automatically generated enrichments, such as language, article types, topics and named entities. Contrastive views of such data reveal patterns, help humanities scholars to improve search strategies and to facilitate a critical assessment of the overall data quality. I\&C is part of the impresso interface for the exploration of digitised and semantically enriched historical newspapers

Do ACE inhibitors improve the response to exercise training in functionally impaired older adults? A randomized controlled trial

<br>Background: Loss of muscle mass and strength with ageing is a major cause for falls, disability, and morbidity in older people. Previous studies have found that angiotensin-converting enzyme inhibitors (ACEi) may improve physical function in older people. It is unclear whether ACEi provide additional benefit when added to a standard exercise training program. We examined the effects of ACEi therapy on physical function in older people undergoing exercise training.</br> <b>Methods:</b> Community-dwelling people aged ≥65 years with functional impairment were recruited through general (family) practices. All participants received progressive exercise training. Participants were randomized to receive either 4 mg perindopril or matching placebo daily for 20 weeks. The primary outcome was between-group change in 6-minute walk distance from baseline to 20 weeks. Secondary outcomes included changes in Short Physical Performance Battery, handgrip and quadriceps strength, self-reported quality of life using the EQ-5D, and functional impairment measured using the Functional Limitations Profile.<p></p> <b>Results:</b> A total of 170 participants (n = 86 perindopril, n = 84 placebo) were randomized. Mean age was 75.7 (standard deviation [SD] 6.8) years. Baseline 6-minute walk distance was 306 m (SD 99). Both groups increased their walk distance (by 29.6 m perindopril, 36.4 m placebo group) at 20 weeks, but there was no statistically significant treatment effect between groups (−8.6m [95% confidence interval: −30.1, 12.9], p = .43). No statistically significant treatment effects were observed between groups for the secondary outcomes. Adverse events leading to withdrawal were few (n = 0 perindopril, n = 4 placebo).<p></p> <b>Interpretation:</b> ACE inhibitors did not enhance the effect of exercise training on physical function in functionally impaired older people.<p></p&gt

Historical Newspaper Content Mining: Revisiting the impresso Project's Challenges in Text and Image Processing, Design and Historical Scholarship

impresso. Media Monitoring of the Past is an interdisciplinary research project in which a team of computational linguists, designers and historians collaborate on the datafication of a multilingual corpus of digitised historical newspapers. The primary goals of the project are to improve text mining tools for historical text, to enrich historical newspapers with (semi-) automatically generated data and to integrate such data into historical research workflows by means of a newly developed user interface. In this paper we discuss our efforts to overcome inherent challenges and to integrate text mining and data visualisation applications in general historical research practices which are characterised by search operations as well as the need to create topical collections

Communities, Harvesting, and CGIF: Building the Research Data Graph at NFDI4Culture

NFDI4Culture provides the Culture Knowledge Graph to facilitate FAIRness in its communities. It provides a lightweight infrastructure that interconnects research data from diverse domains such as architectural studies, art history, musicology, performing arts, and media studies. To allow further exploration of resources across individual knowledge silos, the graph is designed to be compatible with other research areas as well. It requires data providers to implement the Culture Graph Interchange Format, a subset of schema.org classes and properties, either as embedded metadata, an API, or a SPARQL endpoint that can be harvested, or as an RDF data dump. Connections between resources are established via controlled vocabularies, and ingested data is made available via the Culture Information Portal\u27s SPARQL endpoint. After introducing the infrastructural need, the paper reviews comparable solutions, describes the graph, discusses technical choices, and outlines our engagement within and beyond NFDI4Culture

Modulation of vaccine response by concomitant probiotic administration

Evidence suggests that probiotic bacteria modulate both innate and adaptive immunity in the host, and in some situations can result in reduced severity of common illnesses, such as acute rotavirus infection and respiratory infections. Responses to vaccination are increasingly being used to provide high quality information on the immunomodulatory effects of dietary components in humans. The present review focuses on the effect of probiotic administration upon vaccination response. The majority of studies investigating the impact of probiotics on responses to vaccination have been conducted in healthy adults, and at best they show modest effects of probiotics on serum or salivary IgA titres. Studies in infants and in elderly subjects are very limited, and it is too early to draw any firm conclusions regarding the potential for probiotics to act as adjuvants in vaccination. Although some studies are comparable in terms of duration of the intervention and age and characteristics of the subjects, most differ in terms of the probiotic selected. Further well designed, randomized, placebo-controlled studies are needed to fully understand the immunomodulatory properties of probiotics, whether the effects exerted are strain-dependent and age-dependent, and their clinical relevance in enhancing immune protection following vaccination

impresso Text Reuse at Scale. An interface for the exploration of text reuse data in semantically enriched historical newspapers

Text Reuse reveals meaningful reiterations of text in large corpora. Humanities researchers use text reuse to study, e.g., the posterior reception of influential texts or to reveal evolving publication practices of historical media. This research is often supported by interactive visualizations which highlight relations and differences between text segments. In this paper, we build on earlier work in this domain. We present impresso Text Reuse at Scale, the to our knowledge first interface which integrates text reuse data with other forms of semantic enrichment to enable a versatile and scalable exploration of intertextual relations in historical newspaper corpora. The Text Reuse at Scale interface was developed as part of the impresso project and combines powerful search and filter operations with close and distant reading perspectives. We integrate text reuse data with enrichments derived from topic modeling, named entity recognition and classification, language and document type detection as well as a rich set of newspaper metadata. We report on historical research objectives and common user tasks for the analysis of historical text reuse data and present the prototype interface together with the results of a user evaluation

Nutrition, diet and immunosenescence

Ageing is characterized by immunosenescence and the progressive decline in immunity in association with an increased frequency of infections and chronic disease. This complex process affects both the innate and adaptive immune systems with a progressive decline in most immune cell populations and defects in activation resulting in loss of function. Although host genetics and environmental factors, such as stress, exercise and diet can impact on the onset or course of immunosenescence, the mechanisms involved are largely unknown. This review focusses on identifying the most significant aspects of immunosenescence and on the evidence that nutritional intervention might delay this process, and consequently improve the quality of life of the elderly