Afterglow, TL and OSL properties of Mn2+-doped ZnGa2O4 phosphor

The work was supported by Latvian Research Council via LZP-2018/1–0214 research project as well as the Latvian-Ukrainian Joint Research Project (LV-UA/2016/1 in Latvia and M/8-2018 (No. 0118U001672) in Ukraine), and by the NATO SfP Project G4649. The work was also partially supported by the Polish National Science Center (project 2018/31/B/ST8/00774). A. Luchechko gratefully acknowledges a grant from Institute of Physics PAS for a research visit to the Institute.Zinc gallate (ZnGa2O4) spinel ceramics doped with Mn2+ ions was prepared by a solid-state reaction at 1200 °C in air. Manganese concentration was equal to 0.05 mol.% of MnO with respect to ZnO. Ceramics produced in this way show an efficient green emission at about 505 nm under UV or X-ray excitations, which is caused by Mn2+ ions. This green emission is observed also as a relatively long afterglow (visible to the naked eye in the dark for about one hour) after switching-off the X-ray excitation. Time profiles of the beginning of glow and afterglow have been studied together with thermally stimulated (TSL) and optically stimulated (OSL) luminescence. Experimental results demonstrate a presence of few types of shallow and deep traps responsible for the observed afterglow and TSL/OSL emission of the material. The possibility of pulsed optical stimulation and time-resolved OSL characteristics of ZnGa2 O4: Mn2+ has been reported for the first time. The presented results suggest the ZnGa2O4: Mn2+ spinel as a promising material for further fundamental research and possibility of application as a green long-lasting phosphor or storage phosphor for TSL/OSL radiation dosimetry.North Atlantic Treaty Organization G4649; Polish National Science Center project 2018/31/B/ST8/00774; 0118U001672,LV-UA/2016/1,LZP-2018/1–0214; Institute of Solid State Physics, University of Latvia as the Center of Excellence has received funding from the European Union’s Horizon 2020 Framework Programme H2020-WIDESPREAD-01-2016-2017-TeamingPhase2 under grant agreement No. 739508, project CAMART

Lithium intoxication related multiple temporary ecg changes: A case report

Lithium is a widely used mood stabilizer, which may cause cardiac side effects. In this article, we present the case of a 39-year-old woman who had presented with pre-syncope and developed multiple ECG abnormalities that are caused by lithium intoxication and are disappeared after hemodialysis

Decreased vitamin B 12

Background: Oral isotretinoin treatment might influence the levels of vitamin B 12 and folic acid. Aims and Objectives: The aim of this study is to compare vitamin B 12 and folic acid levels in patients with moderate and severe acne vulgaris with those of the healthy control group and to investigate the effect of isotretinoin treatment on these vitamins. Materials and Methods: Patients who completed 6 months of isotretinoin therapy for moderate and severe forms of acne vulgaris and a control group consisting of healthy individuals between February 2011 and March 2012 were included in the study. Before isotretinoin therapy and at 6.- months of the therapy, serum vitamin B 12 and folic acid levels were measured. In the healthy control group, vitamin B 12 and folic acid levels were assessed only once. Results: In total, 120 patients with moderate and severe acne vulgaris who completed 6 months isotretinoin therapy and 100 healthy individuals who constituted the control group were included in the study. Pre-treatment vitamin B 12 values of the patient group were found to be statistically significantly higher (P = 0.002), but any statistically significant difference was not detected in folic acid measurements (P = 0.566). A statistically significant decrease was detected in post-treatment vitamin B 12 and folic acid levels (P < 0.05). Conclusion: Vitamin B 12 /folic acid treatment should be given under medical surveillance before and during isotretinoin therapy. Supplementation of these vitamins should be recommended in cases of their deficiency, so as to decrease the risks of neuropsychiatric and occlusive vascular diseases

Decreased Vitamin B-12 and Folic Acid Concentrations in Acne Patients After Isotretinoin Therapy: A Controlled Study

WOS: 000209782400045Background: Oral isotretinoin treatment might influence the levels of vitamin B-12 and folic acid. Aims and Objectives: The aim of this study is to compare vitamin B-12 and folic acid levels in patients with moderate and severe acne vulgaris with those of the healthy control group and to investigate the effect of isotretinoin treatment on these vitamins. Materials and Methods: Patients who completed 6 months of isotretinoin therapy for moderate and severe forms of acne vulgaris and a control group consisting of healthy individuals between February 2011 and March 2012 were included in the study. Before isotretinoin therapy and at 6.- months of the therapy, serum vitamin B-12 and folic acid levels were measured. In the healthy control group, vitamin B-12 and folic acid levels were assessed only once. Results: In total, 120 patients with moderate and severe acne vulgaris who completed 6 months isotretinoin therapy and 100 healthy individuals who constituted the control group were included in the study. Pre-treatment vitamin B-12 values of the patient group were found to be statistically significantly higher (P = 0.002), but any statistically significant difference was not detected in folic acid measurements (P = 0.566). A statistically significant decrease was detected in post-treatment vitamin B-12 and folic acid levels (P < 0.05). Conclusion: Vitamin B-12/folic acid treatment should be given under medical surveillance before and during isotretinoin therapy. Supplementation of these vitamins should be recommended in cases of their deficiency, so as to decrease the risks of neuropsychiatric and occlusive vascular diseases

The efficacy and safety of Omalizumab in refractory chronspontaneous urticaria: Real-life experience in Turkey

PubMed ID: 30244261Introduction: This study used real-world data to evaluate the effectiveness and reliability of omalizumab in treating recalcitrant chronic spontaneous urticaria in Turkish patients. Methods: Study data were collected retrospectively from eight tertiary-care hospitals in Turkey. This study included 132 patients with chronic spontaneous urticaria that were resistant to H1 antihistamine treatment in a dose up to four times the licensed dose and were treated with 300 mg/month of omalizumab for 6 months. Results: The mean weekly urticarial activity score (UAS7) after omalizumab treatment improved significantly compared to the pretreatment score (p < 0.001). Treatment response was detected primarily in the 1st and 2nd months after treatment. No significant association was observed between omalizumab’s treatment effectiveness and disease-related parameters or laboratory data. The mean dermatology life quality index was 23.12 ± 6.15 before treatment and decreased to 3.55 ± 3.60 6 months after treatment (p < 0.001). No side effects were reported in 89.4% (118) of the patients. Conclusion: This study showed that UAS7 decreased significantly and quality of life improved in omalizumab-treated patients. Moreover, treatment effectiveness was mainly observed in the first 2 months after treatment. However, no association was observed between omalizumab treatment effectiveness and disease-related parameters or laboratory data. © 2018, Slovenian Medical Society. All rights reserved

Anionic transporters and channels in pancreatic islet cells

After a brief description of the so-called consensus hypothesis for the mechanism of stimulus-secretion coupling in the process of glucose-induced insulin release, the present chapter, which deals with anionic transporters and channels in pancreatic islet cells, concerns mainly a second modality for the control of insulin secretion by the hexose. In such a perspective, it draws attention to the NBCe1 Na+/HCO3−cotransporters, the volume-regulated anion channel hypothesis, the experimental model of extracellular hypotonicity, the possible role of NAD(P)H oxidase-derived H2O2 in the activation of volume-regulated anion channels in β-cells exposed to a hypotonic medium, the identity of the anions concerned by the volume-regulated anion channel hypothesis, the expression and function of anoctamin 1 in rodent and human pancreatic islet cells, the possible role of bicarbonate-activated soluble adenylyl cyclase, the identity and role of aquaporins in insulin-producing cells, and a proposed role for volume-regulated anion channels in glucagon secretion.SCOPUS: ch.binfo:eu-repo/semantics/publishe