Can the quality of social research on ethnicity be improved through the introduction of guidance? Findings from a research commissioning pilot exercise

As the volume of UK social research addressing ethnicity grows, so too do concerns regarding the ethical and scientific rigour of this research domain and its potential to do more harm than good. The establishment of standards and principles and the introduction of guidance documents at critical points within the research cycle might be one way to enhance the quality of such research. This article reports the findings from the piloting of a guidance document within the research commissioning process of a major funder of UK social research. The guidance document was positively received by researchers, the majority of whom reported it to be comprehensible, relevant and potentially useful in improving the quality of research proposals. However, a review of the submitted proposals suggested the guidance had had little impact on practice. While guidance may have a role to play, it will need to be strongly promoted by commissioners and other gatekeepers. Findings also suggest the possibility that guidance may discourage some researchers from engaging with ethnicity if it raises problems without solutions; highlighting the need for complementary investments in research capacity development in this area

Fluctuations of the Lyapunov exponent in 2D disordered systems

We report a numerical investigation of the fluctuations of the Lyapunov exponent of a two dimensional non-interacting disordered system. While the ratio of the mean to the variance of the Lyapunov exponent is not constant, as it is in one dimension, its variation is consistent with the single parameter scaling hypothesis

UK devolution and the European Union: a tale of cooperative asymmetry?

The post 1999 devolution project has resulted in a major recalibration of the pre-existing arrangements for making European Union policy within the UK. The devolved administrations in Scotland and Wales (but not the English regions) have gained in electoral legitimacy and legislative powers, and thereby a greater claim to consultation with UK central government. Four key characteristics of EU policy making in a devolved UK are identified. The legal contingency of the 'devolveds'' status has not yet impeded traditional cooperative relations between government tiers, but the stability of the new arrangements remains in question. The UK case is compared to EU regionalisation in other member states and a distinction is drawn between a cooperative regionalist approach (the devolveds) and a consultative one (the English regions)

The statistical mechanics of a polygenic characterunder stabilizing selection, mutation and drift

By exploiting an analogy between population genetics and statistical mechanics, we study the evolution of a polygenic trait under stabilizing selection, mutation, and genetic drift. This requires us to track only four macroscopic variables, instead of the distribution of all the allele frequencies that influence the trait. These macroscopic variables are the expectations of: the trait mean and its square, the genetic variance, and of a measure of heterozygosity, and are derived from a generating function that is in turn derived by maximizing an entropy measure. These four macroscopics are enough to accurately describe the dynamics of the trait mean and of its genetic variance (and in principle of any other quantity). Unlike previous approaches that were based on an infinite series of moments or cumulants, which had to be truncated arbitrarily, our calculations provide a well-defined approximation procedure. We apply the framework to abrupt and gradual changes in the optimum, as well as to changes in the strength of stabilizing selection. Our approximations are surprisingly accurate, even for systems with as few as 5 loci. We find that when the effects of drift are included, the expected genetic variance is hardly altered by directional selection, even though it fluctuates in any particular instance. We also find hysteresis, showing that even after averaging over the microscopic variables, the macroscopic trajectories retain a memory of the underlying genetic states.Comment: 35 pages, 8 figure

Promoting deep learning through design - discussion, student activity and assessment

There is widespread evidence that Australia is currently facing falling student participation rates in science and mathematics subjects at secondary school and university undergraduate levels. The future implications of this science-deficit are widely acknowledged. Unfortunately, science teaching itself is also widely seen as being dull, too content-heavy, delivered to mass-audiences and assessed in ways promoting surface approaches to learning. To address these issues, and issues relating to the apparent lack of challenge for very able students in their first year at university, The University of Queensland developed the Advanced Study Program in Science (ASPinS). This initiative offers an enhanced learning experience to a select group of high-achieving students in addition to their existing undergraduate study in a Science-related degree program. ASPinS offers these students the opportunity to interact with leading research scientists, broaden their understanding of important scientific issues, experience new interactive learning opportunities, undertake research projects and obtain an authentic insight into science as a career. This presentation, however, will only focus on the unique first year course offered within the 3 year ASPinS experience – BIOL1017 “Perspectives in Science”. In this course students are encouraged to think about important current scientific issues from different perspectives – both scientific and non-scientific. Panels of expert scientists use their knowledge and experience to present real scientific issues for students to examine and discuss. These panel discussions cover a spectrum of medical, environmental and social issues, covering different viewpoints and possible solutions. Combining this effective panel model with an array of student-led activities provides an ideal environment for learning. Students are made to apply their new knowledge, discuss issues and construct thoughts, opinions and products – depending on the specifically designed activities. Relevant assessment tasks include group-writing activities and oral presentations which enable students to demonstrate their learning through authentic contexts that are carefully designed to influence the way students learn. Authentic assessment tasks enable students to see a purpose for the product (assessment) they are producing while at the same time enabling them to synthesise the various scientific ‘facts’ and issues they have been discussing. This level of assessment activity, by its nature, encourages higher-order learning. Student evaluations have consistently confirmed that the key to the success of each Module within the course lies in the breadth of speakers selected to represent the different angles associated with the topic under discussion and the related activities and assessment tasks. The findings indicate that students value the opportunity to explore the multi-disciplinary nature of science-related issues and to actually discuss the issues. The “Perspectives in Science” course is a model for the success of combining teaching and learning theory and scholarship, to a particular set of objectives, to create a highly effective learning environment and a meaningful student experience

Estimating translational selection in Eukaryotic Genomes

Natural selection on codon usage is a pervasive force that acts on a large variety of prokaryotic and eukaryotic genomes. Despite this, obtaining reliable estimates of selection on codon usage has proved complicated, perhaps due to the fact that the selection coefficients involved are very small. In this work, a population genetics model is used to measure the strength of selected codon usage bias, S, in 10 eukaryotic genomes. It is shown that the strength of selection is closely linked to expression and that reliable estimates of selection coefficients can only be obtained for genes with very similar expression levels. We compare the strength of selected codon usage for orthologous genes across all 10 genomes classified according to expression categories. Fungi genomes present the largest S values (2.24–2.56), whereas multicellular invertebrate and plant genomes present more moderate values (0.61–1.91). The large mammalian genomes (human and mouse) show low S values (0.22–0.51) for the most highly expressed genes. This might not be evidence for selection in these organisms as the technique used here to estimate S does not properly account for nucleotide composition heterogeneity along such genomes. The relationship between estimated S values and empirical estimates of population size is presented here for the first time. It is shown, as theoretically expected, that population size has an important role in the operativity of translational selection

High-intensity interval walking in combination with acute green tea extract supplementation reduces postprandial blood glucose concentrations in physically inactive participants

Background: Exercise and green tea supplementation have been shown to have the potential to improve postprandial blood glucose concentrations, but past interventions have not often investigated attainable and time effective exercise protocols. Aim: The purpose of this study was to investigate the effects of interval walking exercise and acute green tea extract supplementation on the glycaemic response to an oral glucose tolerance test (OGTT). Method: Twelve physically inactive participants (nine male, three female, age: 22 ± 1 years; body mass: 81.2 ± 16.3 kg; stature: 175.7 ± 9.6 cm; body mass index (in kg/m2): 26.2 ± 4.3) underwent a 2-h OGTT immediately following i) no intervention (REST), ii) placebo and exercise (EX-PLAC), iii) green tea extract supplementation and exercise (EX-GTE), in a random order. The walking exercise consisted of 6 × 1 min of brisk walking (7.92 ± 0.56 km/h) separated by 1 min of slower walking (4.8 km/h). Differences between groups were identified using magnitude-based inferences. Results: The EX-GTE intervention resulted in a ∼9% most likely beneficial effect on blood glucose area under the curve response to the OGTT (702.18 ± 76.90 mmol/L–1·120 min–1) compared with REST (775.30 ± 86.76 mmol/L–1·120 min–1), and a very likely beneficial effect compared with the EX-PLAC (772.04 ± 81.53 mmol/L–1·120 min–1). Conclusion: These data suggest that an EX-GTE intervention can reduce postprandial glucose concentrations in physically inactive individuals

What Have We Learned from Policy Transfer Research? Dolowitz and Marsh Revisited

Over the last decade, policy transfer has emerged as an important concept within public policy analysis, guiding both theoretical and empirical research spanning many venues and issue areas. Using Dolowitz and Marsh's 1996 stocktake as its starting point, this article reviews what has been learned by whom and for what purpose. It finds that the literature has evolved from its rather narrow, state-centred roots to cover many more actors and venues. While policy transfer still represents a niche topic for some researchers, an increasing number have successfully assimilated it into wider debates on topics such as globalisation, Europeanisation and policy innovation. This article assesses the concept's position in the overall ‘tool-kit’ of policy analysis, examines some possible future directions and reflects on their associated risks and opportunities

Negotiations of minority ethnic rugby league players in the Cathar country of France

This article is based on new empirical, qualitative research with minority ethnic rugby league players in the southwest of France. Drawing on similar research on rugby league in the north and the south of England, the article examines how rugby league, traditionally viewed as a white, working-class male game (Collins, 2006; Denham, 2004; Spracklen, 1995, 2001) has had to re-imagine its symbolic boundaries as they are constituted globally and locally to accommodate the needs of players from minority ethnic backgrounds. In particular, the article examines the sense in which experiences of minority ethnic rugby league players in France compare with those of their counterparts in England (Spracklen, 2001, 2007), how rugby league is used in France to construct identity, and in what sense the norms associated with the imaginary community of rugby league are replicated or challenged by the involvement of minority ethnic rugby league players in France. Questions about what it means to be (provincial, national) French (Kumar, 2006) are posed, questions that relate to the role of sport in the construction of Frenchness, and in particular the role of rugby league (and union). © Copyright ISSA and SAGE Publications

Clustered bottlenecks in mRNA translation and protein synthesis

We construct an algorithm that generates large, band-diagonal transition matrices for a totally asymmetric exclusion process (TASEP) with local hopping rate inhomogeneities. The matrices are diagonalized numerically to find steady-state currents of TASEPs with local variations in hopping rate. The results are then used to investigate clustering of slow codons along mRNA. Ribosome density profiles near neighboring clusters of slow codons interact, enhancing suppression of ribosome throughput when such bottlenecks are closely spaced. Increasing the slow codon cluster size, beyond $\approx 3-4$, does not significantly reduce ribosome current. Our results are verified by extensive Monte-Carlo simulations and provide a biologically-motivated explanation for the experimentally-observed clustering of low-usage codons