Does architectural lighting contribute to breast cancer?

OBJECTIVES: There is a growing interest in the role that light plays on nocturnal melatonin production and, perhaps thereby, the incidence of breast cancer in modern societies. The direct causal relationships in this logical chain have not, however, been fully established and the weakest link is an inability to quantitatively specify architectural lighting as a stimulus for the circadian system. The purpose of the present paper is to draw attention to this weakness. DATA SOURCES AND EXTRACTION: We reviewed the literature on the relationship between melatonin, light at night, and cancer risk in humans and tumor growth in animals. More specifically, we focused on the impact of light on nocturnal melatonin suppression in humans and on the applicability of these data to women in real-life situations. Photometric measurement data from the lighted environment of women at work and at home is also reported. DATA SYNTHESIS: The literature review and measurement data demonstrate that more quantitative knowledge is needed about circadian light exposures actually experienced by women and girls in modern societies. CONCLUSION: Without such quantitative knowledge, limited insights can be gained about the causal relationship between melatonin and the etiology of breast cancer from epidemiological studies and from parametric studies using animal models

Assessing the visibility of raised pavement markers and alternative forms of delineation

Raised Pavement Markers (RPMs) are used by a number of transportation agencies with the objective of improving roadway safety, especially in complex roadway geometries and along wet roads. Because of maintenance and cost issues, many transportation agencies are exploring alternatives to RPMs such as wet reflective pavement tape and barrier-mounted reflective delineators. In order to assess the relative potential of these devices to contribute to nighttime driving safety, the luminances of new and used RPM samples from different manufacturers and having different colors and of several alternative delineation devices were measured in the laboratory using a range of geometric conditions relevant to the driving task. From these data, Luminances under representative low-beam headlight illumination were determined and these quantities were used to estimate driver visual performance. Large variations in luminance yielded relatively small differences in visual performance for a viewing distance of 100 m, primarily because of the plateau characteristic of visual performance. Differences in threshold visibility distances were greater, with distances at identification threshold for the devices measured ranging approximately from 150 to 400 m. Used RPMs had luminances 20…30% lower than new RPMs but similar visibility characteristics as new devices. The analysis method in this study may be useful for practitioners seeking to characterize the visual effectiveness of RPMs and other roadway delineation devices and systems

Circadian light

The present paper reflects a work in progress toward a definition of circadian light, one that should be informed by the thoughtful, century-old evolution of our present definition of light as a stimulus for the human visual system. This work in progress is based upon the functional relationship between optical radiation and its effects on nocturnal melatonin suppression, in large part because the basic data are available in the literature. Discussed here are the fundamental differences between responses by the visual and circadian systems to optical radiation. Brief reviews of photometry, colorimetry, and brightness perception are presented as a foundation for the discussion of circadian light. Finally, circadian light (CLA) and circadian stimulus (CS) calculation procedures based on a published mathematical model of human circadian phototransduction are presented with an example

A new approach to understanding the impact of circadian disruption on human health

Abstract Background Light and dark patterns are the major synchronizer of circadian rhythms to the 24-hour solar day. Disruption of circadian rhythms has been associated with a variety of maladies. Ecological studies of human exposures to light are virtually nonexistent, however, making it difficult to determine if, in fact, light-induced circadian disruption directly affects human health. Methods A newly developed field measurement device recorded circadian light exposures and activity from day-shift and rotating-shift nurses. Circadian disruption defined in terms of behavioral entrainment was quantified for these two groups using phasor analyses of the circular cross-correlations between light exposure and activity. Circadian disruption also was determined for rats subjected to a consistent 12-hour light/12-hour dark pattern (12L:12D) and ones subjected to a "jet-lagged" schedule. Results Day-shift nurses and rats exposed to the consistent light-dark pattern exhibited pronounced similarities in their circular cross-correlation functions and 24-hour phasor representations except for an approximate 12-hour phase difference between species. The phase difference reflects the diurnal versus nocturnal behavior of humans versus rodents. Phase differences within species likely reflect chronotype differences among individuals. Rotating-shift nurses and rats subjected to the "jet-lagged" schedule exhibited significant reductions in phasor magnitudes compared to the day-shift nurses and the 12L:12D rats. The reductions in the 24-hour phasor magnitudes indicate a loss of behavioral entrainment compared to the nurses and the rats with regular light-dark exposure patterns. Conclusion This paper provides a quantitative foundation for systematically studying the impact of light-induced circadian disruption in humans and in animal models. Ecological light and activity data are needed to develop the essential insights into circadian entrainment/disruption actually experienced by modern people. These data can now be obtained and analyzed to reveal the interrelationship between actual light exposures and markers of circadian rhythm such as rest-activity patterns, core body temperature, and melatonin synthesis. Moreover, it should now be possible to bridge ecological studies of circadian disruption in humans to parametric studies of the relationships between circadian disruption and health outcomes using animal models.</p

Impacts of Fog Characteristics, Forward Illumination, and Warning Beacon Intensity Distribution on Roadway Hazard Visibility

Warning beacons are critical for the safety of transportation, construction, and utility workers. These devices need to produce sufficient luminous intensity to be visible without creating glare to drivers. Published standards for the photometric performance of warning beacons do not address their performance in conditions of reduced visibility such as fog. Under such conditions light emitted in directions other than toward approaching drivers can create scattered light that makes workers and other hazards less visible. Simulations of visibility of hazards under varying conditions of fog density, forward vehicle lighting, warning beacon luminous intensity, and intensity distribution were performed to assess their impacts on visual performance by drivers. Each of these factors can influence the ability of drivers to detect and identify workers and hazards along the roadway in work zones. Based on the results, it would be reasonable to specify maximum limits on the luminous intensity of warning beacons in directions that are unlikely to be seen by drivers along the roadway, limits which are not included in published performance specifications

Preliminary evidence for a change in spectral sensitivity of the circadian system at night

BACKGROUND: It is well established that the absolute sensitivity of the suprachiasmatic nucleus to photic stimulation received through the retino-hypothalamic tract changes throughout the 24-hour day. It is also believed that a combination of classical photoreceptors (rods and cones) and melanopsin-containing retinal ganglion cells participate in circadian phototransduction, with a spectral sensitivity peaking between 440 and 500 nm. It is still unknown, however, whether the spectral sensitivity of the circadian system also changes throughout the solar day. Reported here is a new study that was designed to determine whether the spectral sensitivity of the circadian retinal phototransduction mechanism, measured through melatonin suppression and iris constriction, varies at night. METHODS: Human adult males were exposed to a high-pressure mercury lamp [450 lux (170 μW/cm(2)) at the cornea] and an array of blue light emitting diodes [18 lux (29 μW/cm(2)) at the cornea] during two nighttime experimental sessions. Both melatonin suppression and iris constriction were measured during and after a one-hour light exposure just after midnight and just before dawn. RESULTS: An increase in the percentage of melatonin suppression and an increase in pupil constriction for the mercury source relative to the blue light source at night were found, suggesting a temporal change in the contribution of photoreceptor mechanisms leading to melatonin suppression and, possibly, iris constriction by light in humans. CONCLUSION: The preliminary data presented here suggest a change in the spectral sensitivity of circadian phototransduction mechanisms at two different times of the night. These findings are hypothesized to be the result of a change in the sensitivity of the melanopsin-expressing retinal ganglion cells to light during the night

Luminous Intensity for Traffic Signals: A Scientific Basis for Performance Specifications

Humnan factors experiments on visual responses to simulated traffic signals using incandescent lamps and light-emitting diodes are described

A Novel Way of Optimizing Headlight Distributions Based on Real-Life Traffic and Eye Tracking Data Part 3: Driver Gaze Behaviour on Real Roads and Optimized Light Distribution

In order to find optimized headlight distributions based on real traffic data, a three-step approach has been chosen. The complete investigations are too extensive to fit into a single paper; this paper is the last of a three part series. Over the three papers, a novel way to optimize automotive headlight distributions based on real-life traffic and eye tracking data is presented. Across all three papers, a total of 119 test subjects participated in the studies with over 15,000 km of driving, including recordings of gaze behaviour, light data, detection distances, and other objects in traffic. In this third paper, driver gaze behaviour is recorded while driving a 128 km round course, covering urban roads, country roads, and motorways. This gaze behaviour is then analysed and compared to prior work covering driver gaze behaviour. Comparing the gaze distributions with roadway object distributions from part two of this series, Analysis of Real-World Traffic Data in Germany and combining them with the idealized baseline headlight distribution from part one, different optimized headlight distributions can be generated. These headlight distributions can be optimized for different driving requirements based on the data that is used and weighting the different road types differently. The resulting headlight distribution is then compared to a standard light distribution in terms of the required luminous flux, angular distribution, and overall shape. Nonetheless, it is the overall approach that has been taken that we see as the primary novel outcome of this investigation, even more than the actual distribution resulting from this effort

Luminous Intensity for Traffic Signals: A Scientific Basis for Performance Specifications - Appendices

Luminous Intensity for Traffic Signals: A Scientific Basis for Performance Specifications - Appendice