Accurate masses for dispersion-supported galaxies

We derive an accurate mass estimator for dispersion-supported stellar systems and demonstrate its validity by analyzing resolved line-of-sight velocity data for globular clusters, dwarf galaxies, and elliptical galaxies. Specifically, by manipulating the spherical Jeans equation we show that the dynamical mass enclosed within the 3D deprojected half-light radius r_1/2 can be determined with only mild assumptions about the spatial variation of the stellar velocity dispersion anisotropy. We find M_1/2 = 3 \sigma_los^2 r_1/2 / G ~ 4 \sigma_los^2 R_eff / G, where \sigma_los^2 is the luminosity-weighted square of the line-of-sight velocity dispersion and R_eff is the 2D projected half-light radius. While deceptively familiar in form, this formula is not the virial theorem, which cannot be used to determine accurate masses unless the radial profile of the total mass is known a priori. We utilize this finding to show that all of the Milky Way dwarf spheroidal galaxies (MW dSphs) are consistent with having formed within a halo of mass approximately 3 x 10^9 M_sun in Lambda CDM cosmology. The faintest MW dSphs seem to have formed in dark matter halos that are at least as massive as those of the brightest MW dSphs, despite the almost five orders of magnitude spread in luminosity. We expand our analysis to the full range of observed dispersion-supported stellar systems and examine their I-band mass-to-light ratios (M/L). The M/L vs. M_1/2 relation for dispersion-supported galaxies follows a U-shape, with a broad minimum near M/L ~ 3 that spans dwarf elliptical galaxies to normal ellipticals, a steep rise to M/L ~ 3,200 for ultra-faint dSphs, and a more shallow rise to M/L ~ 800 for galaxy cluster spheroids.Comment: 20 pages, 13 figures. Accepted to MNRAS on March 27th, 201

Effects of Alcohol on Tests of Executive Functioning in Men and Women: A Dose Response Examination

Alcohol has been shown to affect performance on tasks associated with executive functioning. However, studies in this area have generally been limited to a single dose or gender or have used small sample sizes. The purpose of this study was to provide a more nuanced and systematic examination of alcohol\u27s effects on commonly used tests of executive functioning at multiple dosages in both men and women. Research volunteers (91 women and 94 men) were randomly assigned to one of four drink conditions (alcohol doses associated with target blood alcohol concentrations of .000%, .050%, .075%, and .100%). Participants then completed three tasks comprising two domains of executive functioning: two set shifting tasks, the Trail Making Test and a computerized version of the Wisconsin Card Sorting Task, and a response inhibition task, the Go Stop Impulsivity Paradigm. Impaired performance on set shifting tasks was found at the .100% and .075% dosages, but alcohol intoxication did not impair performance on the Go Stop. No gender effects emerged. Thus, alcohol negatively affects set shifting at moderately high levels of intoxication in both men and women, likely attributable to alcohol\u27s interference with prefrontal cortex function. Although it is well established that alcohol negatively affects response inhibition as measured by auditory stop-signal tasks, alcohol does not appear to exert a negative effect on response inhibition as measured by the Go Stop, a visual stop-signal task

Changeling: A Single Player VR Mystery

Changeling is a VR narrative mystery game focusing upon immersive experience. It was created by aspiring game developers from the Rochester Institute of Technology to experience professional development. Each semester, different sets of students get to work on the game, with past ones working part time. Using the ideas of magical realism and urban fantasy we see each family member respond to uncertainty through the lens of their hopes and fears

The Role of Dwarf Galaxies in Building Large Stellar Halos

The hierarchical theory of galaxy formation rests on the idea that smaller galactic structures merge to form the galaxies that we see today. The past decade has provided remarkable observational support for this scenario, driven in part by advances in spectroscopic instrumentation. Multi-object spectroscopy enabled the discovery of kinematically cold substructures around the Milky Way and M31 that are likely the debris of disrupting satellites. Improvements in high-resolution spectroscopy have produced key evidence that the abundance patterns of the Milky Way halo and its dwarf satellites can be explained by Galactic chemical evolution models based on hierarchical assembly. These breakthroughs have depended almost entirely on observations of nearby stars in the Milky Way and luminous red giant stars in M31 and Local Group dwarf satellites. In the next decade, extremely large telescopes will allow observations far down the luminosity function in the known dwarf galaxies, and they will enable observations of individual stars far out in the Galactic halo. The chemical abundance census now available for the Milky Way will become possible for our nearest neighbor, M31. Velocity dispersion measurements now available in M31 will become possible for systems beyond the Local Group such as Sculptor and M81 Group galaxies. Detailed studies of a greater number of individual stars in a greater number of spiral galaxies and their satellites will test hierarchical assembly in new ways because dynamical and chemical evolution models predict different outcomes for halos of different masses in different environments.Comment: Astro2010 Decadal Survey White Paper, 8 page

The most dark-matter-dominated galaxies : predicted gamma-ray signals from the faintest milky way dwarfs

We use kinematic data from three new nearby, extremely low luminosity Milky Way dwarf galaxies (Ursa Major II, Willman 1, and Coma Berenices) to constrain the properties of their dark matter halos, and from these we make predictions for the γ-ray flux from annihilation of dark matter particles in these halos. We show that these ~10^3 L⊙ dwarfs are the most dark-matter-dominated galaxies known, with total masses within 100 pc that are in excess of 10^6 M⊙. Coupled with their relative proximity, their large masses imply that they should have mean γ-ray fluxes that are comparable to or greater than those of any other known satellite galaxy of the Milky Way. Our results are robust to both variations of the inner slope of the density profile and the effect of tidal interactions. The fluxes could be boosted by up to 2 orders of magnitude if we include the density enhancements caused by surviving dark matter substructure

Effect of alcohol dose on deliberate self-harm in men and women

Objective: Nonexperimental survey and field research support the notion that alcohol use may be associated with deliberate self-harm (DSH) across the spectrum of lethality, from nonsuicidal self-injury (NSSI) through suicide. Nonexperimental studies, however, provide limited information about potential causal relationships between alcohol consumption and DSH. Two previous experiments showed that a relatively high-dose of alcohol increases the likelihood of engaging in DSH in men, with DSH defined by the self-administration of a painful shock (the self-aggression paradigm [SAP]; Berman & Walley, 2003; McCloskey & Berman, 2003). In this study, we examined whether (a) lower doses of alcohol also elicit DSH, (b) this effect occurs for women as well as men, and (c) individual differences in past nonsuicidal self-injury (NSSI) moderate alcohol\u27s effects on DSH. Method: Nonalcohol dependent men and women (N = 210) were assigned either to.00%,.05%,.075%, or.100% blood alcohol concentration (BAC) drink conditions and completed a self-rating scale of NSSI (the Deliberate Self-Harm Inventory [DSHI]; Gratz, 2001). As in previous SAP studies, DSH was operationalized by shock setting behavior during a competitive reaction time (RT) game. Results: Overall, a greater proportion of participants in the.075% and.100% (but not.050%) alcohol conditions self-selected a painful shock to administer compared to participants in the placebo condition. NSSI predicted self-administration of painful shocks, but did not moderate the alcohol effect. Conclusions: Results provide experimental evidence to support the notion that interventions for self-harm should include processes to monitor and limit alcohol intake

Activation loop targeting strategy for design of receptor-interacting protein kinase 2 (RIPK2) inhibitors

Development of selective kinase inhibitors remains a challenge due to considerable amino acid sequence similarity among family members particularly in the ATP binding site. Targeting the activation loop might offer improved inhibitor selectivity since this region of kinases is less conserved. However, the strategy presents difficulties due to activation loop flexibility. Herein, we report the design of receptor-interacting protein kinase 2 (RIPK2) inhibitors based on pankinase inhibitor regorafenib that aim to engage basic activation loop residues Lys169 or Arg171. We report development of CSR35 that displayed > 10-fold selective inhibition of RIPK2 versus VEGFR2, the target of regorafenib. A co-crystal structure of CSR35 with RIPK2 revealed a resolved activation loop with an ionic interaction between the carboxylic acid installed in the inhibitor and the side-chain of Lys169. Our data provides principle feasibility of developing activation loop targeting type II inhibitors as a complementary strategy for achieving improved selectivity

A Complete Spectroscopic Survey of the Milky Way Satellite Segue 1: The Darkest Galaxy

We present the results of a comprehensive Keck/DEIMOS spectroscopic survey of the ultra-faint Milky Way satellite galaxy Segue 1. We have obtained velocity measurements for 98.2% of the stars within 67 pc (10 arcmin, or 2.3 half-light radii) of the center of Segue 1 that have colors and magnitudes consistent with membership, down to a magnitude limit of r=21.7. Based on photometric, kinematic, and metallicity information, we identify 71 stars as probable Segue 1 members, including some as far out as 87 pc. After correcting for the influence of binary stars using repeated velocity measurements, we determine a velocity dispersion of 3.7^{+1.4}_{-1.1} km/s, with a corresponding mass within the half-light radius of 5.8^{+8.2}_{-3.1} x 10^5 Msun. The stellar kinematics of Segue 1 require very high mass-to-light ratios unless the system is far from dynamical equilibrium, even if the period distribution of unresolved binary stars is skewed toward implausibly short periods. With a total luminosity less than that of a single bright red giant and a V-band mass-to-light ratio of 3400 Msun/Lsun, Segue 1 is the darkest galaxy currently known. We critically re-examine recent claims that Segue 1 is a tidally disrupting star cluster and that kinematic samples are contaminated by the Sagittarius stream. The extremely low metallicities ([Fe/H] < -3) of two Segue 1 stars and the large metallicity spread among the members demonstrate conclusively that Segue 1 is a dwarf galaxy, and we find no evidence in favor of tidal effects. We also show that contamination by the Sagittarius stream has been overestimated. Segue 1 has the highest measured dark matter density of any known galaxy and will therefore be a prime testing ground for dark matter physics and galaxy formation on small scales.Comment: 24 pages, 4 tables, 11 figures (10 in color). Submitted for publication in ApJ. V3 revised according to comments from the refere

The DUF1669 domain of FAM83 family proteins anchor casein kinase 1 isoforms

Members of the casein kinase 1 (CK1) family of serine-threonine protein kinases are implicated in the regulation of many cellular processes, including the cell cycle, circadian rhythms, and Wnt and Hedgehog signaling. Because these kinases exhibit constitutive activity in biochemical assays, it is likely that their activity in cells is controlled by subcellular localization, interactions with inhibitory proteins, targeted degradation, or combinations of these mechanisms. We identified members of the FAM83 family of proteins as partners of CK1 in cells. All eight members of the FAM83 family (FAM83A to FAM83H) interacted with the α and α-like isoforms of CK1; FAM83A, FAM83B, FAM83E, and FAM83H also interacted with the δ and ε isoforms of CK1. We detected no interaction between any FAM83 member and the related CK1γ1, CK1γ2, and CK1γ3 isoforms. Each FAM83 protein exhibited a distinct pattern of subcellular distribution and colocalized with the CK1 isoform(s) to which it bound. The interaction of FAM83 proteins with CK1 isoforms was mediated by the conserved domain of unknown function 1669 (DUF1669) that characterizes the FAM83 family. Mutations in FAM83 proteins that prevented them from binding to CK1 interfered with the proper subcellular localization and cellular functions of both the FAM83 proteins and their CK1 binding partners. On the basis of its function, we propose that DUF1669 be renamed the polypeptide anchor of CK1 domain