Estimation of damping through internally excited roll tests

Roll damping represents a key factor for a proper estimation of the ship behaviour in a seaway. However, due to the typical dominance of viscous effects, accurately estimating roll damping is a challenging task. The most common experimental approach for determining roll damping parameters is based on the analysis of roll decays, although forced and excited roll tests in calm water or in waves have been used as well. This paper proposes a technique for estimating roll damping from internally excited roll tests in calm water. Tests are performed by exciting roll motion through an internal shifting mass. Roll damping parameters can then be determined from the analysis of the obtained roll response curves. The paper describes the experimental technique and a nonlinear mathematical model for representing the system dynamics. A procedure is proposed for determining roll damping coefficients, using, as a basis for the analysis, the developed mathematical model. A case study is reported where damping coefficients are determined for a trawler fishing vessel using the proposed technique. Obtained results are compared with those from standard roll decays analysis. For model validation purposes, the experimental roll response curves are also compared with those simulated through the developed mathematical model

A new template background estimate for source searching in TeV gamma-ray astronomy

A new method is described that permits quickly and easily, a 2-dimensional search for TeV gamma-ray sources over large fields of view ~6deg with instruments utilising the imaging atmospheric Cerenkov technique. It employs as a background estimate, events normally rejected according to a cosmic-ray background rejection criterion based on image shape, but with reconstructed directions overlapping the source of interest. This so-called template background model is demonstrated using example data taken with the stereoscopic HEGRA System of Cerenkov Telescopes. Discussion includes comparisons with a conventional background estimate and limitations of the model. The template model is well suited to the search for point-like, moderately extended sources and combinations thereof, and compensates well for localised systematic changes in cosmic-ray background response.Comment: Accepted versio

Hepatitis C virus and non-Hodgkin's lymphomas: Meta-analysis of epidemiology data and therapy options.

Hepatitis C virus (HCV) is a global health problem affecting a large fraction of the world\u2019s population: This virus is able to determine both hepatic and extrahepatic diseases. Mixed cryoglobulinemia, a B-cell \u201cbenign\u201d lymphoproliferative disorders, represents the most closely related as well as the most investigated HCV-related extrahepatic disorder. Since this virus is able to determine extrahepatic [non-Hodgkin\u2019s lymphoma (NHL)] as well as hepatic malignancies (hepatocellular carcinoma), HCV has been included among human cancer viruses. The most common histological types of HCV-associated NHL are the marginal zone, the lymphoplasmacytic and diffuse large cell lymphomas. The role of the HCV in the pathogenesis of the B-cell lymphoproliferative disorders is confirmed also by the responsiveness of the NHL to antiviral therapy. The purpose of this review is to provide an overview of the recent literature and a meta analysis of the epidemiology data, to explain the role of HCV in the development of NHL\u2019s lymphoma. Furthermore, the possibility to treat these HCV-related NHL with the antiviral therapy or with other therapeutic options, like chemotherapy, is also discussed

Tumour-infiltrating lymphocytes bear the 75 kDa tumour necrosis factor receptor.

Tumour necrosis factor alpha (TNF-alpha) is a cytokine with a variety of immunological properties. The identification of two receptors for this molecule, i.e. the 75 kDa and the 55 kDa TNF receptors (TNF-R), recently clarified the mechanisms through which this cytokine provides its wide range of immunomodulatory activities. In this study we have investigated the expression and the functional properties of these receptors on tumour-infiltrating lymphocytes (TILs) recovered from 17 patients with solid cancers (melanoma, colorectal carcinoma and lung cancer). To this end, TIL lines and freshly isolated TILs were evaluated for (a) the expression and the functional role of TNF receptors following culture in the presence of interleukin 2 (IL-2) and (b) the production of TNF-alpha following culture with IL-2 and the role of this cytokine in IL-2-driven TIL proliferation. Flow cytometry analysis demonstrated that TILs bear the 75 kDa TNF-R. Moreover, TIL lines express detectable messages for TNF-alpha and release this cytokine. Functional in vitro studies have shown that anti-TNF-alpha, as well as anti-75 kDa TNF-R antibodies, are able to inhibit the IL-2-induced TIL proliferation. These data demonstrate that TILs are equipped with a fully functional TNF-R system and suggest a putative role for this receptor and its ligand in the activation and expression of TILs following immunotherapy with IL-2

Phenotypic heterogeneity in IGHV-mutated CLL patients has prognostic impact and identifies a subset with increased sensitivity to BTK and PI3Kδ inhibition

The majority of chronic lymphocytic leukemia (CLL) patients are diagnosed with early-stage disease but the currently used prognostic tools appear to be less informative in this group of patients.1 This is especially problematic for patients with mutated immunoglobulin genes (M-CLL) as they have a more diverse clinical course when compared with patients with unmutated immunoglobulin genes (U-CLL).1, 2, 3, 4 Given the emergence of promising targeted, less toxic, therapeutics in CLL,5, 6 there is an increased need to identify patients who might benefit from early treatment with these new agents

The Trigger System of the H.E.S.S. Telescope Array

H.E.S.S. -- The High Energy Stereoscopic System-- is a new system of large atmospheric Cherenkov telescopes for GeV/TeV Gamma-ray astronomy. This paper describes the trigger system of H.E.S.S. with emphasis on the multi-telescope array level trigger. The system trigger requires the simultaneous detection of air-showers by several telescopes at the hardware level. This requirement allows a suppression of background events which in turn leads to a lower system energy threshold for the detection of Gamma-rays. The implementation of the H.E.S.S. trigger system is presented along with data taken to characterise its performance.Comment: 20 pages, 12 figures, Accepted for publication in Astroparticle Physic

Mediterranean biodiversity gradient initiated by basin restriction

Physical connectivity between marine basins facilitates population exchange and hence controls biodiversity. The Mediterranean Sea is a semi-restricted basin with only a small two-way connection to the global ocean, and it is a region heavily impacted by climate change and biological invasions today. The massive migration of non-indigenous species into the basin through the Suez Canal, driven and enabled by climate warming, is drastically changing Mediterranean biodiversity. Understanding therefore the origin and cause(s) of pre-existing biodiversity patterns is crucial for predicting future impacts of climate change. Mediterranean biodiversity exhibits a west-to-east decreasing gradient in terms of species richness, but the processes that resulted in this gradient have only been hypothesized. By examining the fossil record, we provide evidence that this gradient developed 5.33 million years ago at the end of the Messinian Salinity Crisis, and it was therefore caused by the re-population of the basin by marine species with a dominating western source at the Mediterranean¿Atlantic gateway

A search for TeV gamma-ray emission from SNRs, pulsars and unidentified GeV sources in the Galactic plane in the longitude range between -2 deg and 85 deg

Using the HEGRA system of imaging atmospheric Cherenkov telescopes, one quarter of the Galactic plane (-2 deg < l < 85 deg) was surveyed for TeV gamma-ray emission from point sources and moderately extended sources (diameter <= 0.8 deg). The region covered includes 86 known pulsars (PSR), 63 known supernova remnants (SNR) and nine GeV sources, representing a significant fraction of the known populations. No evidence for emission of TeV gamma radiation was detected, and upper limits range from 0.15 Crab units up to several Crab units, depending on the observation time and zenith angles covered. The ensemble sums over selected SNR and pulsar subsamples and over the GeV-sources yield no indication for emission from these potential sources. The upper limit for the SNR population is at the level of 6.7% of the Crab flux and for the pulsar ensemble at the level of 3.6% of the Crab flux.Comment: 10 pages, 5 figures, 4 tables, accepted for publication in A&