Introduction: Second Annual Gallery of Nonlinear Images (Los Angeles, California, 2005)

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/87886/2/041101_1.pd

A linear programming-based method for job shop scheduling

We present a decomposition heuristic for a large class of job shop scheduling problems. This heuristic utilizes information from the linear programming formulation of the associated optimal timing problem to solve subproblems, can be used for any objective function whose associated optimal timing problem can be expressed as a linear program (LP), and is particularly effective for objectives that include a component that is a function of individual operation completion times. Using the proposed heuristic framework, we address job shop scheduling problems with a variety of objectives where intermediate holding costs need to be explicitly considered. In computational testing, we demonstrate the performance of our proposed solution approach

Effect of “Garbha Cintamani Rasa”, an ayurvedic formulation on lipid profile, liver function and kidney function parameters of rat plasma after chronic administration

Garbha Cintamani Rasa (GCM), a classical Ayurvedic preparation which is used in puerperal complications, was studied for its effect on liver function, kidney function and lipid profile after chronic administrations into the biological system. The experimental animal model was rat of both sexes. Triglycerides (TG) content was observed to be increased very high significantly in male as well as female group. Statistically, irrespective of sexes, high significant increase was found in very low density lipoprotein (VLDL). Decrease of total cholesterol (TC), low density lipoprotein (LDL) and high density lipoprotein (HDL) were negligible in male rats. Similar results were shown by female rats also. In both of the sexes, total protein and albumin content of plasma were increased very high significantly. In case of bilirubin, the increase was negligible for all sexes. The serum Effect of “Garbha Cintamani Rasa”, an Ayurvedic Formulation on Lipid Profile, Liver Function and Kidney Function Parameters of Rat Plasma after Chronic Administration. 26 glutamic pyruvic transaminase (sGPT), serum glutamic oxaloacetic transaminase (sGOT) and alkaline phosphatase (ALP) content in the plasma were decreased very high significantly in both of the experimental groups. Creatinine, urea and uric acid were decreased in male and female where only change of creatinine level was significant for both of the sexes. The changes of plasma parameters of both sexes were in similar fashion when one sex group is compared to opposite sex group.I. Jahan Bulbul, M. Obayed Ullah, M. Azizur Rahaman, K. Ashfaqur Rahman, A. Kumar Paul, M.S.K. Choudhur

A mechanistic model of the organization of cell shapes in epithelial tissues

The organization of cells within tissues plays a vital role in various biological processes, including development and morphogenesis. As a result, understanding how cells self-organize in tissues has been an active area of research. In our study, we explore a mechanistic model of cellular organization that represents cells as force dipoles that interact with each other via the tissue, which we model as an elastic medium. By conducting numerical simulations using this model, we are able to observe organizational features that are consistent with those obtained from vertex model simulations. This approach provides valuable insights into the underlying mechanisms that govern cellular organization within tissues, which can help us better understand the processes involved in development and disease

The eROSITA Final Equatorial-Depth Survey (eFEDS) -- Splashback radius of X-ray galaxy clusters using galaxies from HSC survey

We present the splashback radius measurements around the SRG/eROSITA eFEDS X-ray selected galaxy clusters by cross-correlating them with HSC S19A photometric galaxies. The X-ray selection is expected to be less affected by systematics related to projection that affects optical cluster finder algorithms. We use a nearly volume-limited sample of 109 galaxy clusters selected in 0.5-2.0 keV band having luminosity $L_X > 10^{43.5}\,{\rm erg s^{-1} h^{-2}}$ within the redshift $z<0.75$ and obtain measurements of the projected cross-correlation with a signal-to-noise of $17.43$. We model our measurements to infer a three-dimensional profile and find that the steepest slope is sharper than $-3$ and associate the location with the splashback radius. We infer the value of the 3D splashback radius $r_{\rm sp} = 1.45^{+0.30}_{-0.26}\,{\rm h^{-1} Mpc}$. We also measure the weak lensing signal of the galaxy clusters and obtain halo mass $\log[M_{\rm 200m}/{\rm h^{-1}M_\odot}] = 14.52 \pm 0.06$ using the HSC-S16A shape catalogue data at the median redshift $z=0.46$ of our cluster sample. We compare our $r_{\rm sp}$ values with the spherical overdensity boundary $r_{\rm 200m} = 1.75 \pm 0.08\,{\rm h^{-1} Mpc}$ based on the halo mass which is consistent within $1.2\sigma$ with the $\Lambda$CDM predictions. Our constraints on the splashback radius, although broad, are the best measurements thus far obtained for an X-ray selected galaxy cluster sample.Comment: 15 pages, 10 figure

Velocity Segregation and Systematic Biases In Velocity Dispersion Estimates With the SPT-GMOS Spectroscopic Survey

The velocity distribution of galaxies in clusters is not universal; rather, galaxies are segregated according to their spectral type and relative luminosity. We examine the velocity distributions of different populations of galaxies within 89 Sunyaev Zel'dovich (SZ) selected galaxy clusters spanning $0.28 < z < 1.08$. Our sample is primarily draw from the SPT-GMOS spectroscopic survey, supplemented by additional published spectroscopy, resulting in a final spectroscopic sample of 4148 galaxy spectra---2868 cluster members. The velocity dispersion of star-forming cluster galaxies is $17\pm4$% greater than that of passive cluster galaxies, and the velocity dispersion of bright ($m < m^{*}-0.5$) cluster galaxies is $11\pm4$% lower than the velocity dispersion of our total member population. We find good agreement with simulations regarding the shape of the relationship between the measured velocity dispersion and the fraction of passive vs. star-forming galaxies used to measure it, but we find a small offset between this relationship as measured in data and simulations in which suggests that our dispersions are systematically low by as much as 3\% relative to simulations. We argue that this offset could be interpreted as a measurement of the effective velocity bias that describes the ratio of our observed velocity dispersions and the intrinsic velocity dispersion of dark matter particles in a published simulation result. Measuring velocity bias in this way suggests that large spectroscopic surveys can improve dispersion-based mass-observable scaling relations for cosmology even in the face of velocity biases, by quantifying and ultimately calibrating them out.Comment: Accepted to ApJ; 21 pages, 11 figures, 5 table

In vitro studies on antibacterial, antifungal, and cytotoxic properties of Leucas aspera

The leaves of the plant Leucas aspera belonging to the family Lamiaceae was studied to determine the in vitro antibacterial, antifungal, and cytotoxic properties. All extracts showed remarkable antibacterial activity against all of the studied organisms except Escherichia coli. Methanol extract showed stronger activity compared to ethyl acetate and petroleum ether extracts. It showed highest activity against Pseudomonas aeruginosa with zone of inhibition of 15 mm. The standard chloramphenicol did not show any activity against Shigella sonnei. But all the extracts showed moderate activity against this pathogen with zone of inhibition ranging from 10 to 13 mm. None of the extracts has shown any significant antifungal activity against the fungi. Incase of brine shrimp lethality bioassay, methanol extract showed the strongest cytotoxic effect with LC50 value of 4.28 μg/ml which is followed by ethyl acetate extract with LC50 value of 5.36 μg/ml. Thus it can be inferred that this plant may be a potential source of novel bioactive compounds

The Evolution of the Intracluster Medium Metallicity in Sunyaev-Zel'dovich-Selected Galaxy Clusters at 0 < z < 1.5

We present the results of an X-ray spectral analysis of 153 galaxy clusters observed with the Chandra, XMM-Newton, and Suzaku space telescopes. These clusters, which span 0 < z < 1.5, were drawn from a larger, mass-selected sample of galaxy clusters discovered in the 2500 square degree South Pole Telescope Sunyaev Zel'dovich (SPT-SZ) survey. With a total combined exposure time of 9.1 Ms, these data yield the strongest constraints to date on the evolution of the metal content of the intracluster medium (ICM). We find no evidence for strong evolution in the global (r<R500) ICM metallicity (dZ/dz = -0.06 +/- 0.04 Zsun), with a mean value at z=0.6 of = 0.23 +/- 0.01 Zsun and a scatter of 0.08 +/- 0.01 Zsun. These results imply that >60% of the metals in the ICM were already in place at z=1 (at 95% confidence), consistent with the picture of an early (z>1) enrichment. We find, in agreement with previous works, a significantly higher mean value for the metallicity in the centers of cool core clusters versus non-cool core clusters. We find weak evidence for evolution in the central metallicity of cool core clusters (dZ/dz = -0.21 +/- 0.11 Zsun), which is sufficient to account for this enhanced central metallicity over the past ~10 Gyr. We find no evidence for metallicity evolution outside of the core (dZ/dz = -0.03 +/- 0.06 Zsun), and no significant difference in the core-excised metallicity between cool core and non-cool core clusters. This suggests that strong radio-mode AGN feedback does not significantly alter the distribution of metals at r>0.15R500. Given the limitations of current-generation X-ray telescopes in constraining the ICM metallicity at z>1, significant improvements on this work will likely require next-generation X-ray missions.Comment: 11 pages, 8 figures, 2 tables. Submitted to ApJ. Comments welcome

Comparative effectiveness of drugs used to constrict the patent ductus arteriosus: a secondary analysis of the PDA-TOLERATE trial (NCT01958320).

ObjectiveTo evaluate the effectiveness of drugs used to constrict patent ductus arteriosus (PDA) in newborns &lt; 28 weeks.MethodsWe performed a secondary analysis of the multi-center PDA-TOLERATE trial (NCT01958320). Infants with moderate-to-large PDAs were randomized 1:1 at 8.1 ± 2.1 days to either Drug treatment (n = 104) or Conservative management (n = 98). Drug treatments were assigned by center rather than within center (acetaminophen: 5 centers, 27 infants; ibuprofen: 7 centers, 38 infants; indomethacin: 7 centers, 39 infants).ResultsIndomethacin produced the greatest constriction (compared with spontaneous constriction during Conservative management): RR (95% CI) = 3.21 (2.05-5.01)), followed by ibuprofen = 2.03 (1.05-3.91), and acetaminophen = 1.33 (0.55-3.24). The initial rate of acetaminophen-induced constriction was 27%. Infants with persistent moderate-to-large PDA after acetaminophen were treated with indomethacin. The final rate of constriction after acetaminophen ± indomethacin was 60% (similar to the rate in infants receiving indomethacin-alone (62%)).ConclusionIndomethacin was more effective than acetaminophen in producing ductus constriction