Perancangan tokoh Bubu dan MadBull pada Film Animasi 2D "Petualangan si Bubu"

Character design in animation film is very important. In designing a character must have fix concept in order to be able to show the personality, background, and also the uniqueness of the character who has differences from the other characters that can attract the attention and curiosity of the audience on that animation film. The character of this animation films is very diverse, with the emergence of new animations that is reference in making new character. This research was conducted by the author aimed to design Bubu and MadBull figures. Bubu plays the protagonist, and MadBull play the antagonist, that found in this 2D animation film with tittle “Petualangan si Bubu”

Proses Desain Grafis Humas Internal di PT. Garuda Indonesia

Praktek magang ini bertujuan untuk mengetahui proses kerjadi PT. Garuda Indonesia, pelaksanaan magang dimulai pada tanggal 1 Ferbruari sampai dengan 5 April 2019. Lokasi tempat magang penulis ditempatkan pada unit hubungan masyarakat, yang berlokasi di gedung Garuda City Center Soekarno-Hatta. PT. Garuda Indonesia dipilih oleh penulis sebagai tempat magang karena perusahaan tersebut merupakan perusahaan transportasi dalam negri yang cukup besar yang memiliki potensi sebagai bekal penulis. Dalam unit tersebut mecakup pekerjaan yang memberikan informasi kepada seluruh pegawai dan ada juga informasi yang dipublish kepada publik. Penulis juga diajari bagaimana perancangan sebuah infografis dan pemberian informasi dengan baik kepada pegawai maupun masyarakat agar mudah dimengerti. Tidak hanya perancangan infografis saja, penulis juga diajak untuk berpartisipasi pada rapat direksi yang ditugaskan sebagai dokumentasi rapat tersebut. Dalam pengerjaan proses kerja magang penulis mendapatkan banyak kendala didalamnya. Akan tetapi kendala tersebut dapat teratasi atas dukungan dan kerjasama pembimbing dan teman-teman magang di PT. Garuda Indonesia. Sehingga dalam laporan ini tertulis mengenai proses awal kerja magang akhir kerja magang di PT. Garuda Indonesia

Kajian perencanaan beberapa hotspot berbasis IEEE 802.11n di Fakultas Teknik Unsyiah menggunakan softwere airmagnet planner

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How to Improve Solubility and Dissolution of Irbesartan by Fabricating Ternary Solid Dispersions: Optimization and In-Vitro Characterization

The purpose of this study is to improve the solubility and dissolution of a poorly soluble drug, Irbesartan, using solid dispersion techniques. For that purpose, different polymers such as Soluplus®, Kollidon® VA 64, Kolliphor® P 407, and Polyinylpyrrolidone (PVP-K30) were used as carriers at different concentrations to prepare solid dispersion formulations through the solvent evaporation method. In order to prepare binary dispersion formulations, Soluplus® and Kollidon® VA 64 were used at drug: polymer ratios of 1:1, 1:2, 1:3, and 1:4 (w/w). Saturation solubility of the drug in the presence of used carriers was performed to investigate the quantitative increase in solubility. Dissolution studies were performed to explore the drug release behavior from the prepared dispersions. Additionally, the characterization of the prepared formulations was carried out by performing DSC, SEM, XRD, and FTIR studies. The results revealed that among binary systems, K4 formulation (Drug: Kollidon® VA 64 at ratio of 1:4 w/w) exhibited optimal performance in terms of increased solubility, drug release, and other investigated parameters. Furthermore, ternary dispersion formulations of the optimized binary formulation were prepared with two more polymers, Kolliphor® P 407 and Polyvinylpyrrolidone (PVP-K30), at (Drug: Kollidon® VA 64:ternary polymer) ratios of 1:4:1, 1:4:2, and 1:4:3 (w/w). The results showed that KPVP (TD3) exhibited the highest increase in solubility, as well as dissolution rate, among ternary solid dispersion formulations. Results of solubility enhancement by ternary solid dispersion formulations were also supported by FTIR, DSC, XRD, and SEM analysis. Conclusively, it was found that the ternary solid dispersion-based systems were more effective compared to the binary combinations in improving solubility as well as dissolution of a poorly soluble drug (Irbesartan)

REVIEW OF VIBRATION-BASED SURFACE & TERRAIN CLASSIFICATION FOR WHEEL-BASED ROBOT IN PALM OIL PLANTATION: 27th October 2022; 13th December 2022; 21st January 2023; 23rd January 2023

Palm oil can grow in almost flexible topography. On flats, slopes, hilly, or undulating areas and whether on inland or reclaimed coastal areas. This makes the palm oil plantation environment unique with various soil types & surfaces. Each surface has a unique physical characteristic that directly influences the driving, handling, power efficiency, stability and safety of a robot. A mobile robot should have knowledge not limited to obstacles, but also the surface that the robot traverses to estimate wheel slippage and apply corrective measures. This paper discusses the harshness factors in palm oil plantation estates and the effects on wheel traction. We then present our review of several vibration-based surface classification techniques. Based on our survey, a combination of multimodal sensory for surface classification is more suitable to identify surfaces and terrain in palm oil plantations

Palladium(0) catalyzed Suzuki cross-coupling reaction of 2,5-dibromo-3-methylthiophene: selectivity, characterization, DFT studies and their biological evaluations

Thiophene derivatives have shown versatile pharmacological activities. The Suzuki reaction proved a convenient method for C–C bond formations in organic molecules. In the present research work novel derivatives of 2,5-dibromo-3-methylthiophene (3a–k and 3l–p) has been synthesized, via Suzuki coupling reaction in low to moderate yields. A wide range of functional groups were well tolerated in reaction. Density functional theory investigations on all synthesized derivatives (3a–3p) were performed in order to explore the structural properties. The pharmaceutical potential of synthesized compounds was investigated through various bioassays (antioxidant, antibacterial, antiurease activities). The compounds 3l, 3g, 3j, showed excellent antioxidant activity (86.0, 82.0, 81.3%), respectively by scavenging DPPH. Synthesized compounds showed promising antibacterial activity against tested strains. 3b, 3k, 3a, 3d and 3j showed potential antiurease activity with 67.7, 64.2, 58.8, 54.7 and 52.1% inhibition at 50 µg/ml. Results indicated that synthesized molecules could be a potential source of pharmaceutical agents

Fabrication, In Vitro, and In Vivo Assessment of Eucalyptol-Loaded Nanoemulgel as a Novel Paradigm for Wound Healing

Wounds are the most common causes of mortality all over the world. Topical drug delivery systems are more efficient in treating wounds as compared to oral delivery systems because they bypass the disadvantages of the oral route. The aim of the present study was to formulate and evaluate in vitro in vivo nanoemulgels loaded with eucalyptol for wound healing. Nanoemulsions were prepared using the solvent emulsification diffusion method by mixing an aqueous phase and an oil phase, and a nanoemulgel was then fabricated by mixing nanoemulsions with a gelling agent (Carbopol 940) in a 1:1 ratio. The nanoemulgels were evaluated regarding stability, homogeneity, pH, viscosity, Fourier-transform infrared spectroscopy (FTIR), droplet size, zeta potential, polydispersity index (PDI), spreadability, drug content, in vitro drug release, and in vivo study. The optimized formulation, F5, exhibited pH values between 5 and 6, with no significant variations at different temperatures, and acceptable homogeneity and spreadability. F5 had a droplet size of 139 ± 5.8 nm, with a low polydispersity index. FTIR studies showed the compatibility of the drug with the excipients. The drug content of F5 was 94.81%. The percentage of wound contraction of the experimental, standard, and control groups were 100% ± 0.015, 98.170% ± 0.749, and 70.846% ± 0.830, respectively. Statistically, the experimental group showed a significant difference (p < 0.03) from the other two groups. The results suggest that the formulated optimized dosage showed optimum stability, and it can be considered an effective wound healing alternative

Fabrication and Characterizations of Pharmaceutical Emulgel Co-Loaded with Naproxen-Eugenol for Improved Analgesic and Anti-Inflammatory Effects

The aim of this study was to fabricate and characterize a pharmaceutical emulgel co-loaded with naproxen/eugenol for transdermal delivery to improve the analgesic and anti-inflammatory effects and to eliminate GIT adverse reactions. Emulgel was prepared using a slow emulsification method and evaluated for physical appearance, thermodynamic stability, viscosity, pH, spreadability, extrudability, in-vitro drug release, drug content, ex-vivo permeation, drug retention studies and in-vivo studies. The emulgel exhibited good physical attributes, being thermodynamically stable with no phase separation, having excellent homogeneity, and pH 5.5 to 6.5. Slight changes in viscosity, spreadability and extrudability with respect to high temperature were observed (p &gt; 0.05). The drug content was 96.69 &plusmn; 1.18% and 97.24 &plusmn; 1.27% for naproxen and eugenol, respectively. The maximum release of naproxen after 12 h was 85.14 &plusmn; 1.11%, whereas eugenol was 86.67 &plusmn; 1.23% from emulgel following anomalous non-Fickian mechanism. The maximum % permeation of naproxen across skin was 78.5 &plusmn; 1.30, whereas maximum % permeation of eugenol was 83.7 &plusmn; 1.33 after 12 h. The skin retention of eugenol and naproxen was 8.52 &plusmn; 0.22% and 6.98 &plusmn; 0.24%, respectively. The optimized emulgel inhibited the carrageenan induced paw edema. The pain reaction times of optimized emulgel and standard marketed product (Voltral&reg;) were 11.16 &plusmn; 0.17 and 10.36 &plusmn; 0.47, respectively, with no statistically significant difference (p &gt; 0.05). This study concluded that transdermal delivery of naproxen-eugenol emulgel synergized the anti-inflammatory and analgesic effects of naproxen and eugenol

MOESM1 of Palladium(0) catalyzed Suzuki cross-coupling reaction of 2,5-dibromo-3-methylthiophene: selectivity, characterization, DFT studies and their biological evaluations

Additional file 1: Figure S1. HOMO/LUMO surfaces of compounds (3b–3p). Table S1. ESP values of compounds (3a–3p)

In Vitro and In Vivo Evaluation of Hydroxypropyl-β-cyclodextrin-grafted-poly(acrylic acid)/poly(vinyl pyrrolidone) Semi-Interpenetrating Matrices of Dexamethasone Sodium Phosphate

In this paper, we fabricated semi-interpenetrating polymeric network (semi-IPN) of hydroxypropyl-β-cyclodextrin-grafted-poly(acrylic acid)/poly(vinyl pyrrolidone) (HP-β-CD-g-poly(AA)/PVP) by the free radical polymerization technique, intended for colon specific release of dexamethasone sodium phosphate (DSP). Different proportions of polyvinyl pyrrolidone (PVP), acrylic acid (AA), and hydroxypropyl-beta-cyclodextrin (HP-β-CD) were reacted along with ammonium persulphate (APS) as initiator and methylene-bis-acrylamide (MBA) as crosslinker to develop a hydrogel system with optimum swelling at distal intestinal pH. Initially, all formulations were screened for swelling behavior and AP-8 was chosen as optimum formulation. This formulation was capable of releasing a small amount of drug at acidic pH (1.2), while a maximum amount of drug was released at colonic pH (7.4) by the non-Fickian diffusion mechanism. Fourier transformed infrared spectroscopy (FTIR) revealed successful grafting of components and development of semi-IPN structure without any interaction with DSP. Thermogravimetric analysis (TGA) confirmed the thermal stability of developed semi-IPN. X-ray diffraction (XRD) revealed reduction in crystallinity of DSP upon loading in the hydrogel. The scanning electron microscopic (SEM) images revealed a rough and porous hydrogel surface. The toxicological evaluation of semi-IPN hydrogels confirmed their bio-safety and hemocompatibility. Therefore, the prepared hydrogels were pH sensitive, biocompatible, showed good swelling, mechanical properties, and were efficient in releasing the drug in the colonic environment. Therefore, AP-8 can be deemed as a potential carrier for targeted delivery of DSP to treat inflammatory bowel diseases