The response of pre-osteoblasts and osteoclasts to gallium containing mesoporous bioactive glasses.

Mesoporous bioactive glasses (MBGs) in the system SiO2-CaO-P2O5-Ga2O3 have been synthesized by the evaporation induced self-assembly method and subsequent impregnation with Ga cations. Two different compositions have been prepared and the local environment of Ga(III) has been characterized using 29Si, 71Ga and 31P NMR analysis, demonstrating that Ga(III) is efficiently incorporated as both, network former (GaO4 units) and network modifier (GaO6 units). In vitro bioactivity tests evidenced that Ga-containing MBGs retain their capability for nucleation and growth of an apatite-like layer in contact with a simulated body fluid with ion concentrations nearly equal to those of human blood plasma. Finally, in vitro cell culture tests evidenced that Ga incorporation results in a selective effect on osteoblasts and osteoclasts. Indeed, the presence of this element enhances the early differentiation towards osteoblast phenotype while disturbing osteoclastogenesis. Considering these results, Ga-doped MBGs might be proposed as bone substitutes, especially in osteoporosis scenarios

Divalent Metal Vinylphosphonate Layered Materials: Compositional Variability, Structural Peculiarities, Dehydration Behavior, and Photoluminescent Properties

A family of M-VP (M = Ni, Co, Cd, Mn, Zn, Fe, Cu, Pb; VP = vinylphosphonate) and M-PVP (M = Co, Cd; PVP = phenylvinylphosphonate) materials have been synthesized by hydrothermal methods and characterized by FTIR, elemental analysis, and thermogravimetric analysis (TGA). Their structures were determined either by single crystal X-ray crystallography or from laboratory X-ray powder diffraction data. The crystal structure of some M-VP and M-PVP materials is two-dimensional (2D) layered, with the organic groups (vinyl or phenylvinyl) protruding into the interlamellar space. However, the Pb-VP and Cu-VP materials show dramatically different structural features. The porous, three-dimensional (3D) structure of Pb-VP contains the Pb center in a pentagonal pyramid. A Cu-VP variant of the common 2D layered structure shows a very peculiar structure. The structure of the material is 2D with the layers based upon three crystallographically distinct Cu atoms; an octahedrally coordinated Cu2+ atom, a square planar Cu2+ atom and a Cu+ atom. The latter has an unusual co-ordination environment as it is 3-coordinated to two oxygen atoms with the third bond across the double bond of the vinyl group. Metal-coordinated water loss was studied by TGA and thermodiffractometry. The rehydration of the anhydrous phases to give the initial phase takes place rapidly for Cd-PVP but it takes several days for Co-PVP. The M-VP materials exhibit variable dehydration-rehydration behavior, with most of them losing crystallinity during the process.Proyecto nacional MAT2010-15175 (MICINN, España

IN VITRO AND IN VIVO EVALUATIONS OF AN INNOVATIVE BISPHOSPHONATE-COMBINED CALCIUM PHOSPHATE SYSTEM

IOF World Congress on Osteoporosis/10th European Congress on Clinical and Economic Aspects of Osteoporosis and Osteoarthritis, Florence, ITALY, MAY 05-08, 201

Orthopedic implant used as drug delivery system: clinical situation and state of the research.

A partial review is proposed on the existing literature for the research performed in orthopedic implant used as drug delivery system. In the first part, an evaluation is given on the clinical need to deliver a drug in the surrounding of an implant. Secondly, a review of the clinical situation is developed for implants already used as drug delivery system. Experimental works performed for local delivery are reported. In particular, a description is given on the in vitro and in vivo studies where the implant is coated with different proteins or drugs. Finally, a conclusion is proposed on the next step in the development of orthopedic implant as drug delivery system mentioning also the industrial situation

Conversion des résidus de micro-algues en bio-liant pour bitumes

SSCI-VIDE+ECI2D:ING+DLA:NOG:CGENational audienceLes micro-algues sont des micro-organismes capables de croitre très rapidement, dans des photobioréacteursou bassins. Cette biomasse qui compte encore des milliers d’espèces inconnues, est composéede lipides, carbohydrates et protéines. Certaines micro-algues sont exploitées pour l’un de leur composantà forte valeur ajoutée comme par exemple la phycocyanine de la spiruline. Suite à l’extraction de lamolécule souhaitée, les restes des micro-algues ne sont pas exploités alors qu’ils contiennent encore deslipides et autres composés carbonés valorisables. Le projet Algoroute a comme objectif de produire un bioliantpour remplacer le bitume pétrolier (liant des enrobés routiers) à partir de ces déchets. Dans ce but,une liquéfaction hydrothermale a été effectuée sur les résidus et a conduit à l’obtention d’une phasehydrophobe dont les propriétés rhéologiques ont été mesurées

Conversion des résidus de micro-algues en bio-liant pour bitumes

SSCI-VIDE+ECI2D:ING+DLA:NOG:CGENational audienceLes micro-algues sont des micro-organismes capables de croitre très rapidement, dans des photobioréacteursou bassins. Cette biomasse qui compte encore des milliers d’espèces inconnues, est composéede lipides, carbohydrates et protéines. Certaines micro-algues sont exploitées pour l’un de leur composantà forte valeur ajoutée comme par exemple la phycocyanine de la spiruline. Suite à l’extraction de lamolécule souhaitée, les restes des micro-algues ne sont pas exploités alors qu’ils contiennent encore deslipides et autres composés carbonés valorisables. Le projet Algoroute a comme objectif de produire un bioliantpour remplacer le bitume pétrolier (liant des enrobés routiers) à partir de ces déchets. Dans ce but,une liquéfaction hydrothermale a été effectuée sur les résidus et a conduit à l’obtention d’une phasehydrophobe dont les propriétés rhéologiques ont été mesurées

Bisphosphonate Adaptors for Specific Protein Binding on Zirconium Phosphonate-based Microarrays.

International audienc

Towards zirconium phosphonate-based microarrays for probing DNA-protein interactions: critical influence of the location of the probe anchoring groups.

International audienc