Sanguineous Pericardial Effusion and Cardiac Tamponade in the Setting of Graves’ Disease: Report of a Case and Review of Previously Reported Cases

Introduction. Pericardial effusion in the setting of hyperthyroidism is rare. We present a patient with Graves’ disease who developed a sanguineous pericardial effusion and cardiac tamponade. Case Description. A 76-year-old man presenting with fatigue was diagnosed with Graves’ disease and treated with methimazole. Two months later, he was hospitalized for uncontrolled atrial fibrillation. Electrocardiography showed diffuse low voltage and atrial fibrillation with rapid ventricular rate. Chest radiograph revealed an enlarged cardiac silhouette and left-sided pleural effusion. Thyroid stimulating hormone was undetectable, and free thyroxine was elevated. Diltiazem and heparin were started, and methimazole was increased. Transthoracic echocardiography revealed a large pericardial effusion with cardiac tamponade physiology. Pericardiocentesis obtained 1,050 mL of sanguineous fluid. The patient progressed to thyroid storm, treated with propylthiouracil, potassium iodine, hydrocortisone, and cholestyramine. Cultures and cytology of the pericardial fluid were negative. Thyroid hormone markers progressively normalized, and he improved clinically and was discharged. Discussion. We found 10 previously reported cases of pericardial effusions in the setting of hyperthyroidism. Heparin use may have contributed to the sanguineous nature of our patient’s pericardial effusion, but other reported cases occurred without anticoagulation. Sanguineous and nonsanguineous pericardial effusions and cardiac tamponade may be due to hyperthyroidism

Preparation and Foliar Application of Oligochitosan - Nanosilica on the Enhancement of Soybean Seed Yield

Oligochitosan with weight average molecu-lar weight (Mw) of 5000 g/mol was prepared by gamma Co-60 radiation degradation of 4% chitosan solution containing 0.5% H2O2 at 21 kGy. Nanosilica with size of 10 – 30 nm was synthesized by calcination of acid treated rice husk at 700o C for 2 h. The mixture of 2% oligo-chitosan-2% nanosilica was prepared by dispersion of nanosilica in oligochitosan solution. Oligochitosan, nanosilica and their mixture were characterized by gel permeation chromatography (GPC), transmission electr-on microscopy (TEM), X-ray diffraction (XRD), energy dispersive x-ray spectroscopy (EDX), Ultraviolet-visible spectroscopy (UV-Vis), and Furrier transform infrared spectroscopy (FT-IR). Effect of foliar application of oli-gochitosan and oligochitosan-nanosilica on soybean seed yield was conducted in experimental field. Results indi-cated that soybean seed yield increased 10.5 and 17.0% for oligochitosan and oligochitosan-nanosilica, respect-tively for the control. Radiation degraded oligo-chitosan and its mixture with nanosilica can be potentially used for cultivation of soybean with enhanced seed yield

Effective Fragment Potentials for Flexible Molecules: Transferability of Parameters and Amino Acid Database

An accurate but efficient description of noncovalent interactions is a key to predictive modeling of biological and materials systems. The effective fragment potential (EFP) is an ab initio-based force field that provides a physically meaningful decomposition of noncovalent interactions of a molecular system into Coulomb, polarization, dispersion, and exchange-repulsion components. An EFP simulation protocol consists of two steps, preparing parameters for molecular fragments by a series of ab initio calculations on each individual fragment, and calculation of interaction energy and properties of a total molecular system based on the prepared parameters. As the fragment parameters (distributed multipoles, polarizabilities, localized wave function, etc.) depend on a fragment geometry, straightforward application of the EFP method requires recomputing parameters of each fragment if its geometry changes, for example, during thermal fluctuations of a molecular system. Thus, recomputing fragment parameters can easily become both computational and human bottlenecks and lead to a loss of efficiency of a simulation protocol. An alternative approach, in which fragment parameters are adjusted to different fragment geometries, referred to as “flexible EFP”, is explored here. The parameter adjustment is based on translations and rotations of local coordinate frames associated with fragment atoms. The protocol is validated on extensive benchmark of amino acid dimers extracted from molecular dynamics snapshots of a cryptochrome protein. A parameter database for standard amino acids is developed to automate flexible EFP simulations in proteins. To demonstrate applicability of flexible EFP in large-scale protein simulations, binding energies and vertical electron ionization and electron attachment energies of a lumiflavin chromophore of the cryptochrome protein are computed. The results obtained with flexible EFP are in a close agreement with the standard EFP procedure but provide a significant reduction in computational cost

Antineutrino emission and gamma background characteristics from a thermal research reactor

The detailed understanding of the antineutrino emission from research reactors is mandatory for any high sensitivity experiments either for fundamental or applied neutrino physics, as well as a good control of the gamma and neutron backgrounds induced by the reactor operation. In this article, the antineutrino emission associated to a thermal research reactor: the OSIRIS reactor located in Saclay, France, is computed in a first part. The calculation is performed with the summation method, which sums all the contributions of the beta decay branches of the fission products, coupled for the first time with a complete core model of the OSIRIS reactor core. The MCNP Utility for Reactor Evolution code was used, allowing to take into account the contributions of all beta decayers in-core. This calculation is representative of the isotopic contributions to the antineutrino flux which can be found at research reactors with a standard 19.75\% enrichment in $^{235}$U. In addition, the required off-equilibrium corrections to be applied to converted antineutrino energy spectra of uranium and plutonium isotopes are provided. In a second part, the gamma energy spectrum emitted at the core level is provided and could be used as an input in the simulation of any reactor antineutrino detector installed at such research facilities. Furthermore, a simulation of the core surrounded by the pool and the concrete shielding of the reactor has been developed in order to propagate the emitted gamma rays and neutrons from the core. The origin of these gamma rays and neutrons is discussed and the associated energy spectrum of the photons transported after the concrete walls is displayed.Comment: 14 pages, 11 figures, Data in Appendix A and B (13 pages

On subgroups in division rings of type 22

Let $D$ be a division ring with center $F$. We say that $D$ is a {\em division ring of type $2$} if for every two elements $x, y\in D,$ the division subring $F(x, y)$ is a finite dimensional vector space over $F$. In this paper we investigate multiplicative subgroups in such a ring.Comment: 10 pages, 0 figure

Pathogenicity of an H5N1 avian influenza virus isolated in Vietnam in 2012 and reliability of conjunctival samples for diagnosis of infection

The continued spread of highly pathogenic avian influenza virus (HPAIV) subtype H5N1 among poultry in Vietnam poses a potential threat to animals and public health. To evaluate the pathogenicity of a 2012 H5N1 HPAIV isolate and to assess the utility of conjunctival swabs for viral detection and isolation in surveillance, an experimental infection with HPAIV subtype H5N1 was carried out in domestic ducks. Ducks were infected with 10[superscript 7.2] TCID[subscript 50] of A/duck/Vietnam/QB1207/2012 (H5N1), which was isolated from a moribund domestic duck. In the infected ducks, clinical signs of disease, including neurological disorder, were observed. Ducks started to die at 3 days-post-infection (dpi), and the study mortality reached 67%. Viruses were recovered from oropharyngeal and conjunctival swabs until 7 dpi and from cloacal swabs until 4 dpi. In the ducks that died or were sacrificed on 3, 5, or 6 dpi, viruses were recovered from lung, brain, heart, pancreas and intestine, among which the highest virus titers were in the lung, brain or heart. Results of virus titration were confirmed by real-time RT-PCR. Genetic and phylogenetic analysis of the HA gene revealed that the isolate belongs to clade 2.3.2.1 similarly to the H5N1 viruses isolated in Vietnam in 2012. The present study demonstrated that this recent HPAI H5N1 virus of clade 2.3.2.1 could replicate efficiently in the systemic organs, including the brain, and cause severe disease with neurological symptoms in domestic ducks. Therefore, this HPAI H5N1 virus seems to retain the neurotrophic feature and has further developed properties of shedding virus from the oropharynx and conjunctiva in addition to the cloaca, potentially posing a higher risk of virus spread through cross-contact and/or environmental transmission. Continued surveillance and diagnostic programs using conjunctival swabs in the field would further verify the apparent reliability of conjunctival samples for the detection of AIV.Japan Society for the Promotion of Science (Grant-in-Aid for Bilateral Joint Projects)Heiwa Nakajima FoundationNational Institute of Allergy and Infectious Diseases (U.S.) (Contract HHSN2662007000010C

History-sensitive accumulation rules for life-time prediction under variable loading

This is the post-print version of the article. The official published version can be obtained from the link below - Copyright @ 2011 SpringerA general form of temporal strength conditions under variable creep loading is employed to formulate several new phenomenological accumulation rules based on the constant-loading durability diagram. Unlike the well-known Robinson rule of linear accumulation of partial life-times, the new rules allow to describe the life-time sensibility to the load sequence, observed in experiments. Comparison of the new rules with experimental data shows that they fit the data much more accurately than the Robinson rule

Introducing an agricultural app to rice farmers: A pilot study in Can Tho, Vietnam

Plantix is an agricultural app developed by a private company based in Germany which offers a diagnosis and advice for more than 30 crops. It has great potential as a new form of extension service complementing a traditional face-to-face extension service. The CGIAR Plant Health Initiative seeks to introduce the app as part of a package of innovations available for integrated pest and disease management to facilitate behavioral change among farmers. Plantix has been widely used in India but has not yet become very common in Vietnam. The aim of this pilot study was to test the usability of Plantix app for progressive rural rice growers in Vinh Thanh District, Can Tho City, Vietnam. A group of 15 farmers (5 woman and 11 men) participated in the training on use of the app and provided feedback after a two-week trial. The results show that the farmers seem to have some trust issues with the app’s diagnosis, as it reportedly failed to identify or distinguish early signs of certain pests and diseases on young rice. Nevertheless, the farmers showed interest in using Plantix app and considered it a useful tool once its early detection capacity is improved. The participants were experienced large-scaled rice farmers who were already quite familiar with the symptoms of regular pests and diseases. They agreed with the knowledge provided by Plantix. The farmers appeared to be conscious of the recommended dosage of chemical pesticides as written on product labels, however, the current local practice still involves overusing. This suggests that additional measures might be needed along with the introduction and dissemination of Plantix for a stronger impact on farmers’ behaviors. The app can be very useful for farmers when they start growing new crops, when there are new pests and diseases, and when they have difficulties distinguishing one disease from others with similar symptoms. Some of the farmers suggested the need for information about new generation pesticides. They also expressed the need for recommendations of specific “top-ranked” pesticide products, to help them navigate the large number of products and brands currently on the market. Considering the gender division of labor and decision-making, the results show that men are usually responsible for pest and disease management, but women are also involved in decision-making to some extent. It will be interesting to observe how women’s improved knowledge on pest and disease management obtained through Plantix will lead to change in household decisions on pesticide use. The participating farmers use various sources such as TV, Internet, extension workers, input suppliers and peer farmers as means of accessing information and exchanging knowledge. Male farmers tend to learn new agricultural technologies through social networks within their villages and the Internet more often, while the women do that through the Internet and TV. However, both groups trusted their own experience the most. Therefore, introducing the community’s key farmers to new technologies though demonstration and success stories could work as a strategy to ignite behavior change among peer farmers. In addition, communication via the Internet and TV could quickly reach a large number of farmers. Involving input suppliers and extension workers in the introduction of the Plantix app could also be helpful. While this pilot study focused on large-scaled farmers, there are smallholder farmers from poor households in some remote areas in the Mekong Delta. Their needs and knowledge may be significantly different from those of progressive farmers. Introducing the app to different types of farmers can help us understand the diverse needs and priorities of farmers in the process of digitalization

The Vietnamese shrimp trade: livelihoods analysis of stakeholders and market chain analysis

Aquaculture and capture fisheries in Vietnam have been increasing fast in the last decade, especially aquaculture growth rate is 12% for the 1999 – 2003 period, contributing a significant part into the hunger eradication and poverty reduction1. Vietnam is to be ranked into one of the countries potential to produce the aquatic economic in the world, and the fact is that, after 40 years of establishing, the fisheries sector has made remarkable contributions to the country. By the list, at the moment the aquatic products make up about 4 - 5% of GDP and create job opportunities for over 3 three million employees (VASEP, 2004), in which the largest contribution is from shrimp farming. [PDF contains 124 pages.