17 research outputs found
Impact of Waddlia chondrophila infection on pregnancy in the mouse.
The intracellular bacterium Waddlia chondrophila, which belongs to the Chlamydiales order, was found to be associated with miscarriage in humans. There is little to no knowledge regarding the mode of infection, impact on the neonate and pathophysiology of this emerging bacterium. We have previously shown that W. chondrophila induces a systemic infection, organ pathology and elicits T helper type 1-associated humoral immunity in a murine model of genital infection. In the present study, we took advantage of this model of infection to evaluate the impact of this bacterium on the mouse pregnancy. We used two routes of inoculation, vaginal and intrauterine, to introduce infection before and after mating. Our results show that genital infection by W. chondrophila did not have any significant impact on gestation length and maternal weight gain, nor on the number of offspring and their weight. This observation indicates that the mouse model of infection is not suitable to study the effect of W. chondrophila on pregnancy and alternative models of infection, including in vitro ones, should be used. Moreover, an indirect immunopathological mechanism activated by this bacterium should be further explored
SUR ?IMPORTANCE CLINIQUE �VENTUELLE DES FACTEURS DE GROUPES SANGUINS MIS EN �VIDENCE DANS DES FRACTIONS ALLERG�NIQUES DE POUSSI�RE DE MAISON.
Severe Hypercalcemia Associated with Hepatocellular Carcinoma Secreting Intact Parathyroid Hormone: A Case Report
Epidemiological Evaluation of Hearing Damage Related to Strongly Amplified Music (Personal Cassette Players, Discotheques, Rock Concerts) -High-definition Audiometric Survey on 1364 Subjects
Primitive Neuroectodermal Tumor as a Differential Diagnosis of CD56-Positive Tumors in Adults
Alloimmunization to Red Cells and the Association of Alloantibodies Formation with Splenectomy Among Transfusion-Dependent β-Thalassemia Major/HbE Patients
PHARAO : le premier étalon primaire de fréquence, à atomes froids, spatial
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