1,926 research outputs found
Searching for Extra Dimensions in the Early Universe
We investigate extra spatial dimensions () in the early
universe using very high resolution molecular rotational spectroscopic data
derived from a large molecular cloud containing moderately cold carbon monoxide
gas at Z . It turns out that the -dependent quantum
mechanical wavelength transitions are solvable for a linear molecule and we
present the solution here. The CO microwave data allows a very precise
determination of . The probability
that is one in 7794, only 850 million years (using the
standard cosmology) after the Big Bang.Comment: 17 pages, 2 figure
On the use of intermediate infrared and microwave infrared in weather satellites
Intermediate, and microwave infrared measurements by weather satellite
On the uses of intermediate infrared and microwave infrared in meteorological satellites Semiannual report
Intermediate infrared and microwave infrared applications in meteorological satellite
On the uses of intermediate infrared and microwave infrared in meteorological satellites Third semiannual report
Analysis of Nimbus satellite high resolution infrared radiation grid point data, surface emissivity in intermediate region, and meteorological modeling for microwave stud
Ketone Bodies and Signaling in Pancreatic Cancer Cell Lines
Pancreatic cancer is the fourth leading cause of cancer-related deaths in the United States, and 95% of these cases are caused by PDAC (pancreatic ductal adenocarcinoma). Ketone bodies have previously been shown to decrease cell proliferation and cancer-induced cachexia. The molecular mechanism of ketone body-mediated growth inhibition of pancreatic cancer cells is not well understood. Research conducted thus far has not explored which molecular pathways are affected by ketone body treatment in pancreatic cancer cells. In the current study, the effect of the ketone body sodium hydroxybutyrate on the JAK-STAT and mTOR pathways and cell migration was explored. A decrease in cell migration was observed in a dose dependent manner. Levels of p-STAT3 and p-p70 S6K were decreased after 72 hour treatment with 5 and 10 mM sodium hydroxybutyrate. These proteins regulate transcription and translation of several genes involved in cellular growth and proliferation
On the use of intermediate infrared and microwave infrared in weather satellites First annual report
Microwave infrared sensors in meteorological satellite payloads to obtain additional weather informatio
The kinetics of the reaction of superoxide radical with Fe(III) complexes of EDTA, DETAPAC and HEDTA
AbstractTo gain an understanding of the mechanism by which the hydroxyl free radical can arise in superoxide generating systems and learn how different chelaters of iron can inhibit this reaction, a pulse radiolysis kinetic study of the reaction of Oâ2 with Fe(III)EDTA, Fe(III)HEDTA and Fe(III)DETAPAC (or DTPA) was undertaken. Superoxide reacts readily with Fe(III)EDTA and Fe(III)HEDTA with a pH-dependent second-order rate constant having values of 1.9 Ă 106 Mâ1.sâ1 and 7.6 Ă 105 Mâ1.sâ1 at pH 7, respectively. However, the rate constant for the reaction of Oâ2 with Fe(III)DETAPAC was found to be much slower, the upper limit for the rate constant being 104 Mâ1.sâ1. These results in conjunction with spin-trapping experiments with Fe(II)EDTA, Fe(II)HEDTA, Fe(II)DETAPAC and H2O2 suggests that DETAPAC inhibits the formation of OH by slowing the reduction of Fe(III) to Fe(II) and not by inhibiting the Fenton reaction
Risk attribution of Campylobacter infection by age group using exposure modelling
Knowledge on the relative importance of alternative sources of human campylobacteriosis is important in order to implement effective disease prevention measures. The objective of this study was to assess the relative importance of three key exposure pathways (travelling abroad, poultry meat, pet contact) for different patient age groups in Switzerland. With a stochastic exposure model data on Campylobacter incidence for the years 2002-2007 were linked with data for the three exposure pathways and the results of a case-control study. Mean values for the population attributable fractions (PAF) over all age groups and years were 27% (95% CI 17-39) for poultry consumption, 27% (95% CI 22-32) for travelling abroad, 8% (95% CI 6-9) for pet contact and 39% (95% CI 25-50) for other risk factors. This model provided robust results when using data available for Switzerland, but the uncertainties remained high. The output of the model could be improved if more accurate input data are available to estimate the infection rate per exposure. In particular, the relatively high proportion of cases attributed to âother risk factors' requires further attentio
The Policy and Public Management Residency Program: A Proposal to Restore Staffing Capacity in the U.S. House, CBO, CRS, and GAO
There is robust consensus among political scientists, congressional observers, and in Congress that the First Branchâs internal staffing capacity is at historic, dangerous lows. This paper addresses staffing capacity in the U.S. House of Representatives and the three primary congressional support offices: Congressional Research Service (CRS), Congressional Budget Office (CBO), Governmental Accountability Office (CBO). In recent decades, political actors, penurious budgeting, and voter animosity have degraded needed expertise. Such actions include reduced or frozen staffing numbers and pay and poor working conditions. The result is frequent staff burnout and turnover. Bright but inexperienced staff struggle to manage an portfolio of policy issues in which they cannot possibly have a working proficiency. These staff turn to lobbyists inevitably join the âInfluence Industry.â The executive branch staffing, relatively, is substantial. Congress struggles to exercise oversight over federal agencies, in large part, due to a mismatch of resources. Lawmakers face legislative gridlock and the lawmaking they do undertake is often overly responsive to the wishes of K Street.
This capstone proposes a Residency Program to onboard an annual cohort of 300 staff into the U.S. House and three support agencies who are experienced, knowledgeable and credentialed in the fields of public policy and administration. It draws inspiration from similar and established programs. The program would annually onboard 150 recent graduates of masters programs and 150 recent graduates of doctoral programs. The programs must be accredited. The candidates must possess at minimum three yearsâ executive branch experience. The Residents would be paid a living wage and work 12 months. The goal is to find the Residents a permanent job in Congress, hopefully the House or three offices. There would be no job guarantee. By the end of 2025, the annual cohorts of 300 Residents could represent as much as 19.11 percent of the House, or 13.6 percent of the House and three support offices combined
The Parallel Persistent Memory Model
We consider a parallel computational model that consists of processors,
each with a fast local ephemeral memory of limited size, and sharing a large
persistent memory. The model allows for each processor to fault with bounded
probability, and possibly restart. On faulting all processor state and local
ephemeral memory are lost, but the persistent memory remains. This model is
motivated by upcoming non-volatile memories that are as fast as existing random
access memory, are accessible at the granularity of cache lines, and have the
capability of surviving power outages. It is further motivated by the
observation that in large parallel systems, failure of processors and their
caches is not unusual.
Within the model we develop a framework for developing locality efficient
parallel algorithms that are resilient to failures. There are several
challenges, including the need to recover from failures, the desire to do this
in an asynchronous setting (i.e., not blocking other processors when one
fails), and the need for synchronization primitives that are robust to
failures. We describe approaches to solve these challenges based on breaking
computations into what we call capsules, which have certain properties, and
developing a work-stealing scheduler that functions properly within the context
of failures. The scheduler guarantees a time bound of in expectation, where and are the work and
depth of the computation (in the absence of failures), is the average
number of processors available during the computation, and is the
probability that a capsule fails. Within the model and using the proposed
methods, we develop efficient algorithms for parallel sorting and other
primitives.Comment: This paper is the full version of a paper at SPAA 2018 with the same
nam
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