Psoriasis vulgaris: Relationship between oral and periodontal conditions and disease severity

Psoriasis is distributed across the world with a prevalence ranging from 0.5% to 4.6% [1, 2]. This condition has been associated with other diseases, or comorbidities, such as oral cavity involvement, including oral lesions and periodontal disease, thus reaffirming that this is a systemic disease [3, 4]. Psoriasis is a chronic, inflammatory disease which is characterized by the exaggerated proliferation of keratinocytes as a result of immune system activation through T lymphocytes in focal cutaneous areas [5, 6]. In most cases of psoriasis, oral lesions are associated with the presence of geographic and fissured tongue, although data show an increased frequency of associations with generalized pustular psoriasis [7]. It has been estimated that the actual prevalence of fissured tongue and geographic tongue is 6 - 33% and 1-18%, respectively, suggesting that these might represent different expressions of the same disease [7]. However, there is no consensus of the clinical description of what could be considered an oral psoriatic lesion, oral evaluation, or examination, is not a regular procedure in patients with psoriasis [7, 8]. Oral lesions are generally asymptomatic, although there might be tongue swelling and pain when deep fissures are formed [7, 8]. Furthermore, bad tongue hygiene can cause halitosis and tissue swelling due to the accumulation of food residues in fissures, thus causing burning and stinging, especially after contact. However, this association is debatable because it is not known if such oral manifestations are a symptom of disease severity or represent an expression of the disease itself [8]. On the other hand, periodontal disease is marked by an exaggerated response of the immune system to oral microbiota, making it a chronic inflammatory disease which is mediated immunologically, in which immune cells cause inflammation and cellular destruction [9]. Although the two pathologies are similar from the immunological aspect, some characteristics still render them separate diseases and there is no real association known between them [10, 11]. New research has shown that both psoriasis and periodontal disease have both experienced increased prevalence worldwide, and have been associated with other diseases and comorbidities, thus reconfirming that these are, indeed, systemic diseases [12, 13]. There are no existing reports in the published literature which describe the prevalence and frequency of psoriasis and periodontal disease in Colombia. We considered that it was very important for such clinical data to be available because we believe that appropriate examinations should be carried out on all patients with psoriasis, who may have multiple associated comorbidities. We also believe that such examinations should be performed on a regular basis. Furthermore, it is not yet known if the diagnosis of oral psoriasis should be made when lesions in the oral cavity present by themselves, or only at the same time as skin symptoms develop. Consequently, in this study, we aimed to investigate the association between periodontal diagnosis, microbiological components, the presence of IgG against Porphyromonas gingivalis (P. gingivalis), and the clinical manifestations of psoriasis

P050 Oral inflammatory changes associated with inflammatory bowel disease in spondyloarthritis associated with early endoscopic findings

BACKGROUND: Spondyloarthritis (SpA) is a heterogeneous group of chronic autoinflammatory disorders that can present extra-articular gastrointestinal manifestations. Among them is mainly inflammatory bowel disease (IBD). Although IBD mainly affects the intestinal tract, it can include early manifestations evident in the oral cavity. No comparative data on these oral manifestations in patients with SpA were found in the literature. OBJECTIVE: To identify oral clinical manifestations due to changes in the oral mucosa associated with IBD in patients with SpA without a diagnosis of IBD and associate them with endoscopic and histological findings. METHODS: 80 patients with SpA and 52 healthy controls were evaluated. They were assessed intra- and extra-orally, following the modified World Health Organization guideline. In addition, by clinical parameters of rheumatological, gastrointestinal and laboratory activity. Ileocolonoscopy was performed with digital chromoendoscopy with magnification and histological analysis. Comparative analyzes were performed by Chi square tests, Fisher's exact tests, confirmed by univariate regression and discriminant analysis of multiple correspondences. Institutional ethics committee approval cod-2017-023. RESULTS: The patients with SpA had 56% male gender, mean age of 42.8 years (SD ± 10.4) and a BMI in the range of 23.9 - 28.4. The healthy controls, 54% of the male gender with an average age of 41 years (SD ± 13.6) and a body mass index-BMI in the range of 22.9 - 27.6. The patients reported smoking only in 6.2%, however as a smoking history in 31% and passive smokers (15%), the majority employed (41%), married (56%) and professionals (49%). Of the healthy controls, they smoked (15%), with a history of smoking (31%), passive smokers (21%), the majority employed (77%), with their own home (67%), and professionals (54%). The patients with SpA reported a greater presence of some signs and symptoms of gastrointestinal origin 69%, while in the controls it was 7.7% (p = 0.001). Forty one of them were referred to colonoscopy with magnification being in 17.1 % changes in the mucosa of the rectum and in the same frequency changes in the mucosa of the sigmoid colon. Regarding the ileum, changes in the mucosa were evidenced in 41.5% of the cases. The presence of oral lesions was evident and predominated in them (63%) compared to controls p = 0.050. The main oral lesions associated with IBD were gingivitis (55%) (p = 0.001), followed by aphthous stomatitis (3.8%), angular cheilitis (2.6%) and perioral erythema with scaling (1.3%). 100% of the patients who presented alteration of the colonic mucosa presented oral lesions associated with IBD (p = 0039), which was also significantly associated with the presence of gingivitis/aphthous stomatitis (p = 0.029). CONCLUSION: Patients with SpA without a diagnosis of IBD have more oral signs and symptoms compared to healthy controls. Gingivitis is important given its association with early endoscopic and histological findings. Manifestations in the oral cavity can precede intestinal manifestations, therefore the clinical assessment by the oral pathologist in conjunction with gastroenterology and rheumatology allows a timely referral to gastroenterology and an endoscopic and histological evaluation, impacting the quality of life of patients

El entorno Empresarial y el desarrollo de competencias

Thoughts about the importance of labor’s education and the competitiveness within working organizations.The term competencies is the linking element between scientific and technical knowledge, to reach a know-how.Moreover, the importance of education based on competencies is marked out, sustained on a diagnosis among managers and academics, where the real marketing necessities are expressed.Reflexiones sobre la importancia de la educación laboral y la competitividad dentro de la organización laboral.El término ‘competencia’ es el elemento articulador entre el conocimiento científico y el conocimiento técnico, para llegar a un saber-hacer.Se resalta, además, la importancia de la formación basada en competencias, sustentada en un diagnóstico realizado entre empresarios y académicos, donde se expresen las necesidades reales del mercado

El entorno Empresarial y el desarrollo de competencias

Reflexiones sobre la importancia de la educación laboral y la competitividad dentro de la organización laboral. El término ‘competencia’ es el elemento articulador entre el conocimiento científico y el conocimiento técnico, para llegar a un saber-hacer. Se resalta, además, la importancia de la formación basada en competencias, sustentada en un diagnóstico realizado entre empresarios y académicos, donde se expresen las necesidades reales del mercado

Methodology of emotional study for architecture

Este trabajo escrito hace parte del trabajo de grado de diseño industrial, en el cual se intenta dar respuesta a la pregunta de cómo obtener y entregar información personalizada del usuario, que logre aclarar y generar requerimientos para arquitectos al momento de diseñar o remodelar vivienda. Se hace uso de una investigación sobre información cualitativa y emocional en la descripción de sujetos y se muestra el proceso como por el cual se llega al diseño de una metodología que al desarrollarla lograría la consecución de la información personalizada de usuario necesaria para arquitectos y diseñadores de interiores.This written work is part of the degree work in industrial design, which attempts to answer the question of how to obtain and deliver personalized user information, which can clarify and generate requirements for architects when designing or remodeling a home. Research on qualitative and emotional information is used in the description of subjects and the process is shown as by which a methodology is designed that, when developed, would achieve the achievement of the personalized user information necessary for architects and interiors designers.Diseñador (a) IndustrialPregrad

Breaking the walls of discord, a possible alternative for Tunjuelo and San Benito

Romper los muros de la discordia comienza por entender la contaminación producida por las curtiembres en San Benito, localidad de Tunjuelito. Los residuos químicos que genera la industria tradicional del cuero, derivan en contaminación de aire, tierra y agua, que ocasionan enfermedades respiratorias que atentan contra la vida de los habitantes del barrio y afectan las condiciones naturales del río Tunjuelo. Las alcaldías de Bogotá en diferentes periodos han presentado propuestas para recuperar el rio Tunjuelo, pero se trata de una realidad mas compleja que requiere tener en cuenta, entre diferentes intervenciones, la relación reciproca entre San Benito, el río y su contexto. Este proyecto reconoce la relación entre la estructura ecológica principal y la actividad productiva de la industria de las curtiembres como actividad social y económica del barrio. Por medio de estrategias que valoran la tradición curtidora, se fortalece el existente clúster del cuero. Con un enfoque ambiental y de espacio publico, San Benito se convertirá en Cluster nacional en producción, comercialización y formación en diseño de productos de Cuero amigables con el medio ambiente.Curtidores - Habitantes barrio San BenitoBreaking down the walls of discord begins with understanding the pollution produced by the tanneries in San Benito, Tunjuelito. The chemical residues generated by traditional leather industry, lead to air, land and water pollution, which cause respiratory diseases that threaten the lives of the habitants of the neighborhood and affect the natural conditions of the Tunjuelo river. The mayors of Bogotá in different periods have presented proposals to recover the Tunjuelo river, but it is a more complex reality that requires taking into account, between different interventions, the reciprocal relationship between San Benito, the river and its context. This project recognizes the relationship between the main ecological structure and the activity productive of the tanning industry as a social and economic activity of the neighborhood. Through strategies that value the tanning tradition, the existing cluster is strengthened of leather. With an environmental and public space focus, San Benito will become National cluster in production, marketing and training in product design of Environmentally friendly leather.Arquitecto (a)Pregrad

Identification of HPV16-p16INK4a mediated methylation in oral potentially malignant disorder

To evaluate the possible involvement of epigenetic modulation by HPV16-p16INK4a in oral potentially malignant disorder (OPMD). We generated DNA-methylation profiles, according to p16INK4a expression and HPV16 genotype (positive or negative), of OPMD samples and p16INK4a-HPV16 negative samples (used as control), using reduced-representation bisulphite sequencing (RRBS-Seq- Illumina) technology. Twelve samples, four for each group, as follows: 1) p16INK4a+ HPV16+; 2) p16INK4a+ HPV16-; 3) p16INK4a- HPV16-, were analysed in triplicate for DNA-methylation profiles. Fifty-four per cent of DMRs were hypermethylated and 46% were hypomethylated. An increase in methylation of loci in OPMD was independent of the presence of HPV. The hypermethylated genes in HPV+ samples were associated with signalling pathways such as NICD traffics to nucleus, signalling by NOTCH1 (p = 0.008), Interferon-gamma (p = 0.008) and Interleukin-6 signalling (p = 0.027). The hypomethylated genes in HPV infection were associated with TRAF3-dependent IRF activation pathway (p = 0.002), RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways (p = 0.005), TRAF6 mediated IRF7 activation (p = 0.009), TRIF-mediated TLR3/TLR4 signalling (p = 0.011) and MyD88-independent cascade release of apoptotic factors (p = 0.011). Protein association analysis of DMRs in OPMD revealed 19 genes involved in the cell cycle regulation, immune system, and focal adhesion. Aberrantly methylated loci in OPMD were observed in p16INK4a positive samples which suggests that a shift in global methylation status may be important for cancer progression. The results suggest that HPV infection in OPMD induces modulation of genes related to the immune system and regulation of the cellular cycle