WISSIM: An Interactive Simulation Control Language

WISSIM is a computer simulation control language designed to provide a convenient interface between simulation models and their users, and to facilitate the writing of such models. It has been implemented on the UNIVAC 1110 at the University of Wisconsin-Madison, and on the PDP-11 at the International Institute for Applied Systems Analysis. WISSIM can be linked with a user-written FORTRAN program that contains the code for the actual simulation. The control language has commands to interactively modify and display parameters, to control the simulation program, and to produce graphs and reports of results from one or more simulation runs. This report provides a general introduction and describes the commands

The Wisconsin-IIASA Set of Energy/Environment (WISE) Models for Regional Planning and Management: An Overview

This report presents an overview of the analytical framework and quantitative methods used in the IIASA case studies on Regional Energy/Environment Management and Planning. Its purpose is to summarize the structure of the models, to provide a complete listing of the sources of more detailed model and data descriptions, and to indicate how the models are integrated to provide a foundation for regional energy/environment policy maker analysis. The audience for the report includes managers, planners, technical advisors, and modelers. The set of models used in the research project encompasses socioeconomic links to the energy system; energy demand in the residential, industrial, commercial/service, agricultural and transportation sectors; the energy supply sector, environmental impacts associated with the energy system; and policy makers' preferences. The report gives a brief description of the purpose and general structure of each model, data requirements, examples of input and output, and model limitations. As a whole, the models integrate information about energy flows in a region to simulate the energy system and its relationship to other regional variables, e.g., demographic and economic trends and the environment

Characterisation of Crandell-Rees Feline Kidney (CRFK) cells as mesenchymal in phenotype

The Crandell-Rees Feline Kidney Cell (CRFK) is an immortalised cell line derived from the feline kidney that is utilised for the growth of certain vaccinal viruses. Confusion exists as to whether CRFK are epithelial or mesenchymal in phenotype. The aim of this study was to characterise CRFK cells via immunofluorescence, enzyme cytochemistry, western blotting, RT-qPCR for S100A4 and comparison to primary feline proximal tubular epithelial cells (FPTEC) and feline cortical fibroblasts (FCF). CRFK cells were of fusiform morphology and appeared similar to FCF. CRFK expressed the mesenchymal intermediate filament (IF) protein vimentin together with two cell adhesion molecules associated with feline fibroblasts (CD29 and CD44), and lacked expression of the epithelial IF cytokeratin, myogenic IF desmin and endothelial marker von Willebrand factor (vWF). In addition, CRFK did not demonstrate brush border enzyme activity typical of FPTEC. S100A4 gene expression, implicated in both neoplastic transformation and epithelial to mesenchymal transition, was highly upregulated in CRFK in comparison to the primary feline renal cells. CRFK appear phenotypically similar to fibroblasts, rather than tubular epithelial cells, and may have undergone neoplastic transformation or epithelial-to-mesenchymal transition after extensive passaging. This finding may have potential implications for future research utilising this cell line

Evaluating qualitative management research: towards a contingent criteriology

The term qualitative management research embraces an array of non-statistical research practices. Here it is argued that this diversity is an outcome of competing philosophical assumptions which produce distinctive research perspectives and legitimate the appropriation of different sets of evaluation criteria. Some confusion can arise when evaluation criteria constituted by particular philosophical conventions are universally applied to this heterogeneous management field. In order to avoid such misappropriation, this paper presents a first step towards a contingent criteriology located in a metatheoretical analysis of three modes of qualitative management research which are compared with the positivist mainstream to elaborate different forms of evaluation. It is argued that once armed with criteria that vary accordingly, evaluation can reflexively focus upon the extent to which any management research consistently embraces the particular methodological principles that are sanctioned by its a priori philosophical commitments