The innovatization of management institutions in the Russian economy

The study innovatization planning institutions in the system of economic management is a fundamentally new holistic approach to the study of the dynamic interaction of business, government and society in that part of the national institutional matrix in which managerial institutional traps may occur. Their appearance is connected with the use of alternative institutions and losses that turn out on this basis, following an inefficient norm. The effective innovatization of planning institutions in the system of economic management takes place only in case planning periodic institutions are dynamically substituted by adaptive target (continuous) planning institutions that will provide protection from institutional traps in this area of interaction of business, government and society (Postalyuk, 2004). Concerning the article demonstrates the necessity for innovatization of planning institutions in the system of management of the Russian economy; provides a definition and characteristic features of adaptive target (continuous) planning as an alternative to periodic planning, as an interacting system of institutions that affects the efficiency of management of the Russian economy, as an institutional form of the struggle with losses, which arise from the positive and negative factors of management

Design of small-molecule active-site inhibitors of the S1A family proteases as procoagulant and anticoagulant drugs

Vitamin K antagonists (VKA) have long been the default drugs for anticoagulant management in venous thrombosis. While efficacious, they are difficult to use due to interpatient dose–response variability and the risks of bleeding. The approval of fondaparinux, a heparin-derived factor Xa (fXa) inhibitor, provided validation for the development of direct oral anticoagulants (DOAC), and currently such inhibitors of thrombin and fXa are in clinical use. These agents can be used without regular coagulation monitoring, but the inherent risk of bleeding complications associated with blocking the common coagulation pathway remains. Efforts are now underway to develop DOACs that inhibit components of the intrinsic and extrinsic coagulation cascades upstream of thrombin and fX. Evidence from humans and from transgenic animal models suggests that this strategy may provide a better therapeutic margin between antithrombotic and antihemostatic effects. Here the design of active-site inhibitors of S1A proteases involved in coagulation and fibrinolysis is summarized

The innovatization of management institutions in the Russian economy

The study innovatization planning institutions in the system of economic management is a fundamentally new holistic approach to the study of the dynamic interaction of business, government and society in that part of the national institutional matrix in which managerial institutional traps may occur. Their appearance is connected with the use of alternative institutions and losses that turn out on this basis, following an inefficient norm. The effective innovatization of planning institutions in the system of economic management takes place only in case planning periodic institutions are dynamically substituted by adaptive target (continuous) planning institutions that will provide protection from institutional traps in this area of interaction of business, government and society (Postalyuk, 2004). Concerning the article demonstrates the necessity for innovatization of planning institutions in the system of management of the Russian economy; provides a definition and characteristic features of adaptive target (continuous) planning as an alternative to periodic planning, as an interacting system of institutions that affects the efficiency of management of the Russian economy, as an institutional form of the struggle with losses, which arise from the positive and negative factors of management

The innovatization of management institutions in the Russian economy

The study innovatization planning institutions in the system of economic management is a fundamentally new holistic approach to the study of the dynamic interaction of business, government and society in that part of the national institutional matrix in which managerial institutional traps may occur. Their appearance is connected with the use of alternative institutions and losses that turn out on this basis, following an inefficient norm. The effective innovatization of planning institutions in the system of economic management takes place only in case planning periodic institutions are dynamically substituted by adaptive target (continuous) planning institutions that will provide protection from institutional traps in this area of interaction of business, government and society (Postalyuk, 2004). Concerning the article demonstrates the necessity for innovatization of planning institutions in the system of management of the Russian economy; provides a definition and characteristic features of adaptive target (continuous) planning as an alternative to periodic planning, as an interacting system of institutions that affects the efficiency of management of the Russian economy, as an institutional form of the struggle with losses, which arise from the positive and negative factors of management

The innovatization of management institutions in the Russian economy

The study innovatization planning institutions in the system of economic management is a fundamentally new holistic approach to the study of the dynamic interaction of business, government and society in that part of the national institutional matrix in which managerial institutional traps may occur. Their appearance is connected with the use of alternative institutions and losses that turn out on this basis, following an inefficient norm. The effective innovatization of planning institutions in the system of economic management takes place only in case planning periodic institutions are dynamically substituted by adaptive target (continuous) planning institutions that will provide protection from institutional traps in this area of interaction of business, government and society (Postalyuk, 2004). Concerning the article demonstrates the necessity for innovatization of planning institutions in the system of management of the Russian economy; provides a definition and characteristic features of adaptive target (continuous) planning as an alternative to periodic planning, as an interacting system of institutions that affects the efficiency of management of the Russian economy, as an institutional form of the struggle with losses, which arise from the positive and negative factors of management