A Chronically Implanted, Continuous pH Monitoring System for Rats

Many body systems operate within a strict pH range, and any deviation can cause harm. pH measurement systems are used in many biomedical research fields. Measurement systems have been able to continuously record pH for a short period of time wirelessly, or over a long period of time with wires, but no system is currently capable of long term, wireless, continuous pH recording. This paper proposes a new pH measurement system that is capable of such measurement. The system is composed of inexpensive, micro-scale, and easy to manufacture pH sensitive and reference electrodes and a data acquisition and transmission module that is wirelessly powered. The system is small enough to be chronically implanted in a rat. In vitro testing of the system showed a linear, stable pH response. The system provides a new tool to researchers who wish to study pH in vivo, chronically, and in micro scale applications

Optimizing Filter-Probe Diffusion Weighting in the Rat Spinal Cord for Human Translation

Diffusion tensor imaging (DTI) is a promising biomarker of spinal cord injury (SCI). In the acute aftermath, DTI in SCI animal models consistently demonstrates high sensitivity and prognostic performance, yet translation of DTI to acute human SCI has been limited. In addition to technical challenges, interpretation of the resulting metrics is ambiguous, with contributions in the acute setting from both axonal injury and edema. Novel diffusion MRI acquisition strategies such as double diffusion encoding (DDE) have recently enabled detection of features not available with DTI or similar methods. In this work, we perform a systematic optimization of DDE using simulations and an in vivo rat model of SCI and subsequently implement the protocol to the healthy human spinal cord. First, two complementary DDE approaches were evaluated using an orientationally invariant or a filter-probe diffusion encoding approach. While the two methods were similar in their ability to detect acute SCI, the filter-probe DDE approach had greater predictive power for functional outcomes. Next, the filter-probe DDE was compared to an analogous single diffusion encoding (SDE) approach, with the results indicating that in the spinal cord, SDE provides similar contrast with improved signal to noise. In the SCI rat model, the filter-probe SDE scheme was coupled with a reduced field of view (rFOV) excitation, and the results demonstrate high quality maps of the spinal cord without contamination from edema and cerebrospinal fluid, thereby providing high sensitivity to injury severity. The optimized protocol was demonstrated in the healthy human spinal cord using the commercially-available diffusion MRI sequence with modifications only to the diffusion encoding directions. Maps of axial diffusivity devoid of CSF partial volume effects were obtained in a clinically feasible imaging time with a straightforward analysis and variability comparable to axial diffusivity derived from DTI. Overall, the results and optimizations describe a protocol that mitigates several difficulties with DTI of the spinal cord. Detection of acute axonal damage in the injured or diseased spinal cord will benefit the optimized filter-probe diffusion MRI protocol outlined here

Development of a narrowband multichannel active noise control system for enclosures

This paper presents the development of a multichannel active noise control system for enclosures. It is applied on reducing low frequency car engine noise, where passive noise control techniques are inefficient. This work focuses on system optimization for optimal results when implementing on a commercial digital signal processor

The Dynamic Fault Tree Rare Event Simulator

The dynamic-fault-tree rare event simulator, DFTRES, is a statistical model checker for dynamic fault trees (DFTs), supporting the analysis of highly dependable systems, e.g. with unavailability or unreliability under 10^(-30). To efficiently estimate such low probabilities, we apply the Path-ZVA algorithm to implement Importance Sampling with minimal user input. Calculation speed is further improved by selective automata composition and bisimulation reduction. DFTRES reads DFTs in the Galileo or JANI textual formats. The tool is written in Java 11 with multi-platform support, and it is released under the GPLv3. In this paper we describe the architecture, setup, and input language of DFTRES, and showcase its accurate estimation of dependability metrics of (resilient) repairable DFTs from the FFORT benchmark suite.</p

A Coupled Remote Sensing and Simplified Surface Energy Balance Approach to Estimate Actual Evapotranspiration from Irrigated Fields

Accurate crop performance monitoring and production estimation are critical for timely assessment of the food balance of several countries in the world. Since 2001, the Famine Early Warning Systems Network (FEWS NET) has been monitoring crop performance and relative production using satellite-derived data and simulation models in Africa, Central America, and Afghanistan where ground-based monitoring is limited because of a scarcity of weather stations. The commonly used crop monitoring models are based on a crop water-balance algorithm with inputs from satellite-derived rainfall estimates. These models are useful to monitor rainfed agriculture, but they are ineffective for irrigated areas. This study focused on Afghanistan, where over 80 percent of agricultural production comes from irrigated lands. We developed and implemented a Simplified Surface Energy Balance (SSEB) model to monitor and assess the performance of irrigated agriculture in Afghanistan using a combination of 1-km thermal data and 250-m Normalized Difference Vegetation Index (NDVI) data, both from the Moderate Resolution Imaging Spectroradiometer (MODIS) sensor. We estimated seasonal actual evapotranspiration (ETa) over a period of six years (2000-2005) for two major irrigated river basins in Afghanistan, the Kabul and the Helmand, by analyzing up to 19 cloud-free thermal and NDVI images from each year. These seasonal ETa estimates were used as relative indicators of year-to-year production magnitude differences. The temporal water-use pattern of the two irrigated basins was indicative of the cropping patterns specific to each region. Our results were comparable to field reports and to estimates based on watershed-wide crop water-balance model results. For example, both methods found that the 2003 seasonal ETa was the highest of all six years. The method also captured water management scenarios where a unique year-to-year variability was identified in addition to water-use differences between upstream and downstream basins. A major advantage of the energy-balance approach is that it can be used to quantify spatial extent of irrigated fields and their water-use dynamics without reference to source of water as opposed to a water-balance model which requires knowledge of both the magnitude and temporal distribution of rainfall and irrigation applied to fields

Human-Robot Team Interaction Through Wearable Haptics for Cooperative Manipulation

The interaction of robot teams and single human in teleoperation scenarios is beneficial in cooperative tasks, for example the manipulation of heavy and large objects in remote or dangerous environments. The main control challenge of the interaction is its asymmetry, arising because robot teams have a relatively high number of controllable degrees of freedom compared to the human operator. Therefore, we propose a control scheme that establishes the interaction on spaces of reduced dimensionality taking into account the low number of human command and feedback signals imposed by haptic devices. We evaluate the suitability of wearable haptic fingertip devices for multi-contact teleoperation in a user study. The results show that the proposed control approach is appropriate for human-robot team interaction and that the wearable haptic fingertip devices provide suitable assistance in cooperative manipulation tasks

Photon-counting detector computed tomography in cardiac imaging

Photon-counting detector computed tomography (PCD-CT) has emerged as a revolutionary technology in CT imaging. PCD-CT offers significant advancements over conventional energy-integrating detector CT, including increased spatial resolution, artefact reduction and inherent spectral imaging capabilities. In cardiac imaging, PCD-CT can offer a more accurate assessment of coronary artery disease, plaque characterisation and the in-stent lumen. Additionally, it might improve the visualisation of myocardial fibrosis through qualitative late enhancement imaging and quantitative extracellular volume measurements. The use of PCD-CT in cardiac imaging holds significant potential, positioning itself as a valuable modality that could serve as a one-stop-shop by integrating both angiography and tissue characterisation into a single examination. Despite its potential, large-scale clinical trials, standardisation of protocols and cost-effectiveness considerations are required for its broader integration into clinical practice. This narrative review provides an overview of the current literature on PCD-CT regarding the possibilities and limitations of cardiac imaging.</p

Drought Monitoring and Assessment: Remote Sensing and Modeling Approaches for the Famine Early Warning Systems Network

Drought monitoring is an essential component of drought risk management. It is usually carried out using drought indices/indicators that are continuous functions of rainfall and other hydrometeorological variables. This chapter presents a few examples of how remote sensing and hydrologic modeling techniques are being used to generate a suite of drought monitoring indicators at dekadal (10-day), monthly, seasonal, and annual time scales for several selected regions around the world. Satellite-based rainfall estimates are being used to produce drought indicators such as standardized precipitation index, dryness indicators, and start of season analysis. The Normalized Difference Vegetation Index is being used to monitor vegetation condition. Several satellite data products are combined using agrohydrologic models to produce multiple short- and long-term indicators of droughts. All the data sets are being produced and updated in near-real time to provide information about the onset, progression, extent, and intensity of drought conditions. The data and products produced are available for download from the Famine Early Warning Systems Network (FEWS NET) data portal at http:// earlywarning.usgs.gov. The availability of timely information and products support the decision-making processes in drought-related hazard assessment, monitoring, and management with the FEWS NET. The drought-hazard monitoring approach perfected by the U.S. Geological Survey for FEWS NET through the integration of satellite data and hydrologic modeling can form the basis for similar decision support systems. Such systems can operationally produce reliable and useful regional information that is relevant for local, district-level decision making