Physiological Coregulation Intervention Over Video Call in New Relational Dyads

Physiological linkage, the degree to which physiological behavior of one partner in a relationship is related to the physiological behavior of the other partner, is a well-documented process. Electrodermal activity (EDA) and heart rate variability (HRV) are two physiological measures for which physiological linkage has been observed (Timmons, et al., 2015). A more specific term, coregulation, has been proposed to specify a process of mutual physiological regulation within a relational dyad towards a homeostatic set point (Butler & Randall, 2013). While an important construct, there is a present lack of intervention studies seeking to increase the capacity for coregulation in relational dyads. Furthermore, there has been a recent massive increase in video call technologies, in response to the global Covid-19 pandemic. Therefore, this author conducted an intervention study over video call that sought to observe if: a) physiological linkage occurs between relational dyads interfacing via video call and b) the relational capacity for coregulation can be increased over time via a relational play intervention carried out over three weeks on video call. Results showed partial support for hypothesis one, partnered participants’ HRV was significantly correlated at baseline and during the stress-inducing exercise, regardless of group assignment. Results supported the null hypothesis for hypothesis two, demonstrating that the intervention dyads did not exhibit a higher degree of coregulation during posttest compared to the control dyads. However, all dyads demonstrated a return to homeostatic baseline after a stressor at both pretest and posttest, suggesting that relational dyads can effectively coregulate in response to a stressor while interacting over video call. Implications will be discussed below

799-2 Left Ventricular (LV) and Myocyte Electrophysiology with the Development of Dilated Cardiomyopathy (DCM); Effects of Angiotensin II Receptor (AT1 AT-II) Blockade

Ventricular arrhythmias are a significant cause of morbidity and mortality with DCM, and AT1 AT-II receptor activation has been implicated to play a role in arrhythmogenesis. However, the effects of AT1, AT-II receptor activation on changes in LV function and myocyte electrophysiology during the progression of DCM remain unexplored. Accordingly, this study measured weekly changes in LV function (ejection fraction, LVEF; peak systolic wall stress, LVWS) and surface electrocardiography (R-R interval, QRS duration, QTc interval), and myocyte action potentials (resting membrane, RM; upstroke velocity, Vmax; duration at 90% repolarization, APD90) at terminal study in 3 groups of dogs (n=6/group): DCM, chronic pace (216 bpm, 4 weeks); DCM/AT-BLOCK, chronic pace and treatment with a specific non-peptide AT1 AT-II antagonist (SR 47436 (BMS 186295); 30mg/kg BID); and control (CON). All measurements were made with the pacemaker deactivated.LVEF (%)LVWS (g/cm2)R-R (ms).QRS (ms).QTc (ms)Week 2:CON68.7±3.2133±14646±9958.4±1.3291±13DCM40.9±4.1*184±16*519±4060.7±1.9316±9DCM/AT-Block44.1±3.7*138±10+540±566.32±1.2*325±9Week4:CON73.1±2.4127±10629±4557.6±1.4314±9DCM35.2±3.5*223±16*505±41*62.0±1.9313±9DCM/AT-Block35.2±2.7*160±13*+578±4865.7±1.5*296±6*p<0.05 vs CON+p<0.05 vs DCMWith DCM, RM (-71±l* vs -78±1mV) and APD90 (257±9* vs 226±7ms) increased, and Vmax decreased (121±5* vs 158±9V/s) compared to CON. In contrast, with AT-BLOCK, RM became more negative (-76±1+mV), APD90 was reduced (183±14*+) and Vmax increased (165±13+).SummaryAT1 AT-II receptor blockade during the progression of DCM caused significant changes in LV myocardial conduction and myocyte action potentials. These results suggest that AT1 AT-II receptor activation plays a contributory role toward the changes in LV electrophysiology with DCM

System support software for the Space Ultrareliable Modular Computer (SUMC)

The highly transportable programming system designed and implemented to support the development of software for the Space Ultrareliable Modular Computer (SUMC) is described. The SUMC system support software consists of program modules called processors. The initial set of processors consists of the supervisor, the general purpose assembler for SUMC instruction and microcode input, linkage editors, an instruction level simulator, a microcode grid print processor, and user oriented utility programs. A FORTRAN 4 compiler is undergoing development. The design facilitates the addition of new processors with a minimum effort and provides the user quasi host independence on the ground based operational software development computer. Additional capability is provided to accommodate variations in the SUMC architecture without consequent major modifications in the initial processors

Field evidence for the upwind velocity shift at the crest of low dunes

Wind topographically forced by hills and sand dunes accelerates on the upwind (stoss) slopes and reduces on the downwind (lee) slopes. This secondary wind regime, however, possesses a subtle effect, reported here for the first time from field measurements of near-surface wind velocity over a low dune: the wind velocity close to the surface reaches its maximum upwind of the crest. Our field-measured data show that this upwind phase shift of velocity with respect to topography is found to be in quantitative agreement with the prediction of hydrodynamical linear analysis for turbulent flows with first order closures. This effect, together with sand transport spatial relaxation, is at the origin of the mechanisms of dune initiation, instability and growth.Comment: 13 pages, 6 figures. Version accepted for publication in Boundary-Layer Meteorolog

Prediction of preterm birth with and without preeclampsia using mid-pregnancy immune and growth-related molecular factors and maternal characteristics.

OBJECTIVE:To evaluate if mid-pregnancy immune and growth-related molecular factors predict preterm birth (PTB) with and without (±) preeclampsia. STUDY DESIGN:Included were 400 women with singleton deliveries in California in 2009-2010 (200 PTB and 200 term) divided into training and testing samples at a 2:1 ratio. Sixty-three markers were tested in 15-20 serum samples using multiplex technology. Linear discriminate analysis was used to create a discriminate function. Model performance was assessed using area under the receiver operating characteristic curve (AUC). RESULTS:Twenty-five serum biomarkers along with maternal age <34 years and poverty status identified >80% of women with PTB ± preeclampsia with best performance in women with preterm preeclampsia (AUC = 0.889, 95% confidence interval (0.822-0.959) training; 0.883 (0.804-0.963) testing). CONCLUSION:Together with maternal age and poverty status, mid-pregnancy immune and growth factors reliably identified most women who went on to have a PTB ± preeclampsia

Beam-target interaction experiments for bremsstrahlung converter applications

The authors are investigating the possible adverse effects of (1) backstreaming ion emission from the Bremsstrahlung converter target and (2) the interaction of the resultant plasma with the electron beam during subsequent pulses for multi-pulse radiography facilities. These effects would primarily manifest themselves in a static focusing system as a rapidly varying x-ray spot. To study these effects, they are conducting beam-target interaction experiments on the ETA-II accelerator (a 6.0 MeV, 2.5 kA, 70 ns FWHM pulsed, electron accelerator). They are measuring spot dynamics and characterizing the resultant plasma for various configurations. Thus far, their experiments show that the first effect is not strongly present when the beam initially interacts with the target. Electron beam pulses delivered to the target after formation of a plasma are strongly affected. They have also performed initial experiments to determine the effect of the beam propagating through the plasma. This data shows that the head of the beam is relatively robust, but that backstreaming ions from the plasma can still manifest itself as a dynamic focus toward the tail of the beam. They report on the details of the experimental work to suppress these effects

Awareness of genetic risk in the Dominantly Inherited Alzheimer Network (DIAN)

Introduction: Although some members of families with autosomal dominant Alzheimer's disease mutations learn their mutation status, most do not. How knowledge of mutation status affects clinical disease progression is unknown. This study quantifies the influence of mutation awareness on clinical symptoms, cognition, and biomarkers. / Methods: Mutation carriers and non‐carriers from the Dominantly Inherited Alzheimer Network (DIAN) were stratified based on knowledge of mutation status. Rates of change on standard clinical, cognitive, and neuroimaging outcomes were examined. / Results: Mutation knowledge had no associations with cognitive decline, clinical progression, amyloid deposition, hippocampal volume, or depression in either carriers or non‐carriers. Carriers who learned their status mid‐study had slightly higher levels of depression and lower cognitive scores. / Discussion: Knowledge of mutation status does not affect rates of change on any measured outcome. Learning of status mid‐study may confer short‐term changes in cognitive functioning, or changes in cognition may influence the determination of mutation status