A New Family of Cavernicolous Millipedes with the Description of a New Genus and Species from Idaho (Diplopoda: Chordeumida: Chordeumidea)

The Chordeumidea is accumulating species names faster than any other group of North American Diplopoda. About one-half its species, 47, have been described since 1950. This recent growth has occurred because the small size, localized populations, and, frequently, cave habitus of these millipeds have obstructed thorough collection in the past. These factors have only recently been overcome by comprehensive collecting. As a result of this rapidgrowth and the many artificial groupings which result from it, much organization of the higher classification remains to be done. Hoffman (1961) emphasizes that co- operation between workers, more thorough descriptions, more accurate illustrations, and revisions are necessary if a proper classification is to be attained. Described herein is a new cave form unique among the known North American Chordeumidea. Related to Cleidogonidae, Conotylidae, and Bactropidae, it is distinguished from these families by having the ninth legs reduced and unsegmented. This species represents the type of a new family, which we name after the state in which it was collected

Feasibility Study of a Bi-directional Centrifugal Pump for DBT class 45 CST Gearbox Used in Underground Coal mining Operation

This paper presents a feasibility study of using a bi-directional centrifugal pump into DBT’s Series 45 CST gearbox. The suitability of other pumps for cooling and the design of a new symmetrical centrifugal pump that would be suited to the series 45 CST gearbox have been reviewed with financial versus functionality and usability. The analysis and results of this study indicate that by introducing the newly designed bi-directional pump, DBT may save over $370k in production costs over 10 years. This equates to a savings of$1850 per gearbox which is about a 26% saving on the current set-up, and thus bi-directional pump is reasonably feasible

The impact of item parceling ratios and strategies on the internal structure of assessment center ratings: A study using confirmatory factor analysis.

The aim of the present study was to investigate whether using item parcels instead of single indicators would increase support for the factorial validity of assessment center (AC) ratings in factor analytic applications. Factor analytic analyses of AC ratings are often plagued by poor model fit as well as admissibility and termination problems. In the present study, three purposive item parceling strategies, in conjunction with three parceling approaches (specifying different ratios of indicators to dimensions), were investigated in relation to five confirmatory factor analysis specifications of AC ratings across two AC samples (Sample 1: N = 244; Sample 2: N = 320). The findings were equivocal across the two samples. Nonetheless, a three-parcel approach using a factorial allocation strategy performed better that a one-parcel approach (akin to the postexercise dimension rating). (PsycInfo Database Record (c) 2021 APA, all rights reserved

Absorption of Manganese and Iron in a Mouse Model of Hemochromatosis

Hereditary hemochromatosis, an iron overload disease associated with excessive intestinal iron absorption, is commonly caused by loss of HFE gene function. Both iron and manganese absorption are regulated by iron status, but the relationships between the transport pathways of these metals and how they are affected by HFE-associated hemochromatosis remain poorly understood. Loss of HFE function is known to alter the intestinal expression of DMT1 (divalent metal transporter-1) and Fpn (ferroportin), transporters that have been implicated in absorption of both iron and manganese. Although the influence of HFE deficiency on dietary iron absorption has been characterized, potential effects on manganese metabolism have yet to be explored. To investigate the role of HFE in manganese absorption, we characterized the uptake and distribution of the metal in Hfe−/− knockout mice after intravenous, intragastric, and intranasal administration of 54Mn. These values were compared to intravenous and intragastric administration of 59Fe. Intestinal absorption of 59Fe was increased and clearance of injected 59Fe was also increased in Hfe−/− mice compared to controls. Hfe−/− mice displayed greater intestinal absorption of 54Mn compared to wild-type Hfe+/+ control mice. After intravenous injection, the distribution of 59Fe to heart and liver was greater in Hfe−/− mice but no remarkable differences were observed for 54Mn. Although olfactory absorption of 54Mn into blood was unchanged in Hfe−/− mice, higher levels of intranasally-instilled 54Mn were associated with Hfe−/− brain compared to controls. These results show that manganese transport and metabolism can be modified by HFE deficiency

A Voltage-Dependent Persistent Sodium Current in Mammalian Hippocampal-Neurons

ABSTRACT Currents generated by depolarizing voltage pulses were recorded in neurons from the pyramidal cell layer of the CA1 region of rat or guinea pig hip-pocampus with single electrode voltage-clamp or tight-seal whole-cell voltage-clamp techniques. In neurons in situ in slices, and in dissociated neurons, subtrac-tion of currents generated by identical depolarizing voltage pulses before and after exposure to tetrodotoxin revealed a small, persistent current after the transient current. These currents could also be recorded directly in dissociated neurons in which other ionic currents were effectively suppressed. It was concluded that the persistent current was carded by sodium ions because it was blocked by TIX, decreased in amplitude when extraceUular sodium concentration was reduced, and was not blocked by cadmium. The amplitude of the persistent sodium current var-ied with clamp potential, being detectable at potentials as negative as- 70 mV and reaching a maximum at ~-40 mV. The maximum amplitude at-40 mV in 21 cells in slices was-0.34 0.05 nA (mean 1 SEM) and-0.21 0.05 nA in 10 dissociated neurons. Persistent sodium conductance increased sigmoidally with

The transformation of xenoestrogenic prenylated flavonoids from hop (Humulus lupulus) inflorescences during the beer brewing process.

Hops contain many prenylated flavonoids, some of which are estrogenic, i.e. they mimic the female sex hormone 17β-estradiol. Being exposed to excess estrogenic compounds (estrogens) is problematic to health by causing developmental disorders. For example, genital abnormalities and augmentation of breast cancer. The most potent phytoestrogen known is 8-prenylnaringenin and is present in hops and beer. In addition, xanthohumol and isoxanthohumol can be transformed by the gut microflora into 8-prenylnaringenin, increasing the estrogenic potential of hops. Studies have shown that during the beer brewing process the concentration of the prenylated flavonoids decrease from start to finish, but there have been no studies carried out on an industrial scale. Therefore, an analysis of the fate of the potential estrogens during the beer brewing process on an industrial scale in the present project was carried out. The findings show that the beer brewing process causes these compounds to decrease in concentration during the brewing process and that xanthohumol isomerises into isoxanthohumol. Also, beer contains compounds that have the potential to be estrogenic, but the concentration of these are far less than what would cause a detrimental health affect in humans. Lastly, analysis was difficult due to their low concentrations found in beer and this is why a method using chemiluminescence was carried out with the aim of improving the analysis

General performance factors and group differences in assessment center ratings

PURPOSE – The purpose of this paper is to establish the extent of general performance factors (GPF) in assessment center (AC) exercises and dimensions. The study further aims to determine if larger GPF contributes to larger ethnic group differences across exercises and dimensions that are more cognitively loaded in an emerging market context. DESIGN/METHODOLOGY/APPROACH – The authors analyzed data across three independent AC samples (Sample 1: N = 172; Sample 2: N = 281; Sample 3: N = 428). The Schmid-Leiman solution was used to determine the extent of GPF in AC exercises and dimensions. An independent samples t-test and Cohen’s d was used to determine the size of ethnic group differences across exercises and dimensions. FINDINGS – The results indicate that GPF is consistently large for the in-basket exercise. Furthermore, dimensions that are more cognitively loaded, such as problem solving, strategic thinking, and business acumen, seem to produce the largest ethnic group differences. Overall, the research indicates that larger GPF is associated with larger ethnic group differences in relation to specific AC dimensions and exercises. ORIGINALITY/VALUE – The authors add to the literature by investigating the prevalence of a GPF in AC ratings across AC exercises and dimensions. A novel contribution of the research attempts to link the prevalence of a GPF in AC ratings to group membership in South Africa. The study offers an alternative statistical analysis procedure to examine GPF in AC ratings.IS

Best practice guidelines for the use of the assessment centre method in South Africa (5th edition)

ORIENTATION : Assessment Centres (ACs) have a long and successful track record in South Africa when used for selection and development purposes. The popularity of the approach is mainly attributable to the ACs’ numerous strengths, which include the perceived fairness, practical utility and strong associations with on-the-job performance. To maintain the integrity of the AC, it is important for practitioners and decision makers to apply the method in a consistent and standardised manner. RESEARCH PURPOSE : The purpose of the report is to provide practitioners and decision makers with practical guidelines and concrete procedures when using ACs as part of the organisation’s human resource management strategy. MOTIVATION FOR THE STUDY : The past decade has seen significant advances in the science and practice of ACs. Now in its fifth edition, the revised Guidelines seek to provide important information to practitioners and decision makers on a number of factors when used in conjunction with the AC method, namely, technology, validation, legislation, ethics and culture. MAIN FINDINGS : The Guidelines provide specific suggestions and recommendations for using technology as part of the manner of delivery. Issues of culture, diversity and representation are also discussed. New features of the Guidelines include more concrete guidance on how to conduct a validation study as well as unpacking several ethical dilemmas that practitioners may encounter. Of critical importance is a position statement on the use of ACs in relation to new legislation (Employment Equity Amendment Act, Section 8, clause d) pertaining to psychometric testing. PRACTICAL/MANAGERIAL IMPLICATIONS : The Guidelines serve as a benchmark of best practice for practitioners and decision makers who intend on, or are currently, using ACs in their organisations. CONTRIBUTION/VALUE-ADD : In the absence of formal standards governing the use of ACs in South Africa, the Guidelines provide an important step towards establishing standardisation in the use of the AC method. The Guidelines provide (1) guidance to industrial and organisational psychologists, organisational consultants, human resource management specialists, generalists and the Department of Labour, and others designing and conducting ACs; (2) information to managers deciding whether to introduce AC methods; (3) instructions to assessors taking part in the AC; (4) guidance on the use of technology and navigating diverse cultural contexts; and (5) a reference for professionals on best practice considerations in the useof the AC method.http://www.sajip.co.zaam2016Human Resource Managemen

Ferristatin II Promotes Degradation of Transferrin Receptor-1 In Vitro and In Vivo

Previous studies have shown that the small molecule iron transport inhibitor ferristatin (NSC30611) acts by down-regulating transferrin receptor-1 (TfR1) via receptor degradation. In this investigation, we show that another small molecule, ferristatin II (NSC8679), acts in a similar manner to degrade the receptor through a nystatin-sensitive lipid raft pathway. Structural domains of the receptor necessary for interactions with the clathrin pathway do not appear to be necessary for ferristatin II induced degradation of TfR1. While TfR1 constitutively traffics through clathrin-mediated endocytosis, with or without ligand, the presence of Tf blocked ferristatin II induced degradation of TfR1. This effect of Tf was lost in a ligand binding receptor mutant G647A TfR1, suggesting that Tf binding to its receptor interferes with the drug’s activity. Rats treated with ferristatin II have lower TfR1 in liver. These effects are associated with reduced intestinal 59Fe uptake, lower serum iron and transferrin saturation, but no change in liver non-heme iron stores. The observed hypoferremia promoted by degradation of TfR1 by ferristatin II appears to be due to induced hepcidin gene expression

Sperm selection in natural conception:what can we learn from Mother Nature to improve assisted reproduction outcomes?

BACKGROUND: In natural conception only a few sperm cells reach the ampulla or the site of fertilization. This population is a selected group of cells since only motile cells can pass through cervical mucus and gain initial entry into the female reproductive tract. In animals, some studies indicate that the sperm selected by the reproductive tract and recovered from the uterus and the oviducts have higher fertilization rates but this is not a universal finding. Some species show less discrimination in sperm selection and abnormal sperm do arrive at the oviduct. In contrast, assisted reproductive technologies (ART) utilize a more random sperm population. In this review we contrast the journey of the spermatozoon in vivo and in vitro and discuss this in the context of developing new sperm preparation and selection techniques for ART. METHODS: A review of the literature examining characteristics of the spermatozoa selected in vivo is compared with recent developments in in vitro selection and preparation methods. Contrasts and similarities are presented. RESULTS AND CONCLUSIONS: New technologies are being developed to aid in the diagnosis, preparation and selection of spermatozoa in ART. To date progress has been frustrating and these methods have provided variable benefits in improving outcomes after ART. It is more likely that examining the mechanisms enforced by nature will provide valuable information in regard to sperm selection and preparation techniques in vitro. Identifying the properties of those spermatozoa which do reach the oviduct will also be important for the development of more effective tests of semen quality. In this review we examine the value of sperm selection to see how much guidance for ART can be gleaned from the natural selection processes in vivo