Securitization as an Instrument of Administration of Territorial Self-Government Units’ Finances

Celem niniejszego artykułu jest przedstawienie możliwości zastosowania instytucji sekutyryzacji przez jednostki samorządu terytorialnego dla efektywnego zarządzania środkami budżetowymi. Dokonana analiza opiera się na regulacjach ustawy o finansach publicznych z 2005 r. Autor próbuje zaklasyfikować środki nabyte w ramach sekularyzacji do jednej z kategorii środków publicznych wymienionych w art. 5 ustawy. Ponadto rozważa zastosowanie sekutyryzacji w różnych jednostkach samorządu terytorialnego stosownie do ustawy o dochodach jednostek samorządu terytorialnego z 2003 r.The University of Szczecin (Poland

Acknowledgments

From January to June 2015, eleven students from the Bachelor Programmes Arts and Culture and European Studies participated in the course Transparency in Perspective at Maastricht University. This course was organised in the context of the Maastricht University Research Based Learning Project (MaRBLe), and was supervised by Dr. Nico Randeraad. This book includes shortened versions of the original papers of the students who have participated in the course. We would like to thank the organisers of the MaRBLe project, our external advisers, and in particular Dr. Nico Randeraad, for their support throughout the entire research process

Conclusion

Based on the Baconian imperative that "knowledge is power", the drive for transparency gathers up ever-more speed. Especially in politics and economics, transparency has become a widely used catchphrase. Transparency is supposed to alter information asymmetries, improve market efficiency and establish a more inclusive and fair political praxis. While transparency is hoped to alter power relations, and thus to be a revolutionary or at least a reformative tool, surveillance is the privilege of those already in power, and thus regarded as a reactionary tool.        The studies in this joint volume have investigated this dichotomy by looking at various actors in regard to their possibility to change or cement existing power relations, symmetries, improve market efficiency, and establish a more inclusive and fair political praxis. While transparency is hoped to alter power relations, and thus to be a revolutionary or at least a reformative tool, surveillance is the privilege of those already in power. Each contribution, in its unique way, took a skeptical stance towards potential power shifts induced through societal or behavioral changes. This book examined a multitude of societal actors and the power relations between them. Although all contributions highlighted very different subject matters, some common themes emerged. These common themes ought to be highlighted in this final section. Moreover, this final chapter allows us to briefly summarise the central themes and most important finding of each article.        The first contribution treats surveillance and transparency as two sides of the same coin in the sense that both are attempts at changing behaviour by increasing the visibility of actors. Zeijl examines several attempts at transparency from a wide variety of actors. He argues that transparency, as it is currently put in practice by governments and companies, is more lip service than real concern with accountability and openness. Zeijl claims that these attempts at transparency are influenced by the logic of surveillance and therefore consolidate already existing power relations. While there are alternative ways of constructing transparency, they all have possible adverse effects that cannot and should not be easily cast aside. Therefore, one needs to critically assess what the exact benefits of transparency are in order to reach a balanced judgement on whether these possible adverse effects are worth the risk. Since transparency is more often invoked than defined, it is absolutely crucial to pay attention to the structure that transparency is supposed to assume, its organisation, its agents, and its potential impacts. Otherwise, transparency becomes a metaphysical catchphrase to graze (political) support rather than a real concern for accountability and openness

Introduction

"Scientia potentia est" – knowledge is power. Many people seem to read this phrase, attributed to Francis Bacon, as a mission statement. If knowledge is power, then it is easy to understand why people demand more transparency and why at the same time surveillance increases. Transparency and surveillance are means to acquire knowledge and information. For centuries, governments have been surveilling their people to ensure that they behave according to their wishes

From bench to bedside: in vitro and in vivo evaluation of a neonate-focused nebulized surfactant delivery strategy.

BACKGROUND: Non-invasive delivery of nebulized surfactant has been a neonatology long-pursued goal. Nevertheless, the clinical efficacy of nebulized surfactant remains inconclusive, in part, due to the great technical challenges of depositing nebulized drugs in the lungs of preterm infants. The aim of this study was to investigate the feasibility of delivering nebulized surfactant (poractant alfa) in vitro and in vivo with an adapted, neonate-tailored aerosol delivery strategy. METHODS: Particle size distribution of undiluted poractant alfa aerosols generated by a customized eFlow-Neos nebulizer system was determined by laser diffraction. The theoretical nebulized surfactant lung dose was estimated in vitro in a clinical setting replica including a neonatal continuous positive airway pressure (CPAP) circuit, a cast of the upper airways of a preterm neonate, and a breath simulator programmed with the tidal breathing pattern of an infant with mild respiratory distress syndrome (RDS). A dose-response study with nebulized surfactant covering the 100-600\u2009mg/kg nominal dose-range was conducted in RDS-modelling, lung-lavaged spontaneously-breathing rabbits managed with nasal CPAP. The effects of nebulized poractant alfa on arterial gas exchange and lung mechanics were assessed. Exogenous alveolar disaturated-phosphatidylcholine (DSPC) in the lungs was measured as a proxy of surfactant deposition efficacy. RESULTS: Laser diffraction studies demonstrated suitable aerosol characteristics for inhalation (mass median diameter, MMD\u2009=\u20093\u2009\u3bcm). The mean surfactant lung dose determined in vitro was 13.7%\u2009\ub1\u20094.0 of the 200\u2009mg/kg nominal dose. Nebulized surfactant delivered to spontaneously-breathing rabbits during nasal CPAP significantly improved arterial oxygenation compared to animals receiving CPAP only. Particularly, the groups of animals treated with 200\u2009mg/kg and 400\u2009mg/kg of nebulized poractant alfa achieved an equivalent pulmonary response in terms of oxygenation and lung mechanics as the group of animals treated with instilled surfactant (200\u2009mg/kg). CONCLUSIONS: The customized eFlow-Neos vibrating-membrane nebulizer system efficiently generated respirable aerosols of undiluted poractant alfa. Nebulized surfactant delivered at doses of 200\u2009mg/kg and 400\u2009mg/kg elicited a pulmonary response equivalent to that observed after treatment with an intratracheal surfactant bolus of 200\u2009mg/kg. This bench-characterized nebulized surfactant delivery strategy is now under evaluation in Phase II clinical trial (EUDRACT No.:2016-004547-36)

From bench to bedside: In vitro and in vivo evaluation of a neonate-focused nebulized surfactant delivery strategy

Background: Non-invasive delivery of nebulized surfactant has been a neonatology long-pursued goal. Nevertheless, the clinical efficacy of nebulized surfactant remains inconclusive, in part, due to the great technical challenges of depositing nebulized drugs in the lungs of preterm infants. The aim of this study was to investigate the feasibility of delivering nebulized surfactant (poractant alfa) in vitro and in vivo with an adapted, neonate- tailored aerosol delivery strategy. Methods: Particle size distribution of undiluted poractant alfa aerosols generated by a customized eFlow-Neos nebulizer system was determined by laser diffraction. The theoretical nebulized surfactant lung dose was estimated in vitro in a clinical setting replica including a neonatal continuous positive airway pressure (CPAP) circuit, a cast of the upper airways of a preterm neonate, and a breath simulator programmed with the tidal breathing pattern of an infant with mild respiratory distress syndrome (RDS). A dose-response study with nebulized surfactant covering the 100\u2013600 mg/kg nominal dose-range was conducted in RDS-modelling, lung-lavaged spontaneously-breathing rabbits managed with nasal CPAP. The effects of nebulized poractant alfa on arterial gas exchange and lung mechanics were assessed. Exogenous alveolar disaturated-phosphatidylcholine (DSPC) in the lungs was measured as a proxy of surfactant deposition efficacy. Results: Laser diffraction studies demonstrated suitable aerosol characteristics for inhalation (mass median diameter, MMD = 3 \u3bcm). The mean surfactant lung dose determined in vitro was 13.7% \ub1 4.0 of the 200 mg/kg nominal dose. Nebulized surfactant delivered to spontaneously-breathing rabbits during nasal CPAP significantly improved arterial oxygenation compared to animals receiving CPAP only. Particularly, the groups of animals treated with 200 mg/kg and 400 mg/kg of nebulized poractant alfa achieved an equivalent pulmonary response in terms of oxygenation and lung mechanics as the group of animals treated with instilled surfactant (200 mg/kg). Conclusions: The customized eFlow-Neos vibrating-membrane nebulizer system efficiently generated respirable aerosols of undiluted poractant alfa. Nebulized surfactant delivered at doses of 200 mg/kg and 400 mg/kg elicited a pulmonary response equivalent to that observed after treatment with an intratracheal surfactant bolus of 200 mg/kg. This bench-characterized nebulized surfactant delivery strategy is now under evaluation in Phase II clinical trial (EUDRACT No.:2016\u2013004547-36)