Finding counterparts for All-sky X-ray surveys with Nway: a Bayesian algorithm for cross-matching multiple catalogues

We release the AllWISE counterparts and Gaia matches to 106,573 and 17,665 X-ray sources detected in the ROSAT 2RXS and XMMSL2 surveys with |b|>15. These are the brightest X-ray sources in the sky, but their position uncertainties and the sparse multi-wavelength coverage until now rendered the identification of their counterparts a demanding task with uncertain results. New all-sky multi-wavelength surveys of sufficient depth, like AllWISE and Gaia, and a new Bayesian statistics based algorithm, NWAY, allow us, for the first time, to provide reliable counterpart associations. NWAY extends previous distance and sky density based association methods and, using one or more priors (e.g., colors, magnitudes), weights the probability that sources from two or more catalogues are simultaneously associated on the basis of their observable characteristics. Here, counterparts have been determined using a WISE color-magnitude prior. A reference sample of 4524 XMM/Chandra and Swift X-ray sources demonstrates a reliability of ~ 94.7% (2RXS) and 97.4% (XMMSL2). Combining our results with Chandra-COSMOS data, we propose a new separation between stars and AGN in the X-ray/WISE flux-magnitude plane, valid over six orders of magnitude. We also release the NWAY code and its user manual. NWAY was extensively tested with XMM-COSMOS data. Using two different sets of priors, we find an agreement of 96% and 99% with published Likelihood Ratio methods. Our results were achieved faster and without any follow-up visual inspection. With the advent of deep and wide area surveys in X-rays (e.g. SRG/eROSITA, Athena/WFI) and radio (ASKAP/EMU, LOFAR, APERTIF, etc.) NWAY will provide a powerful and reliable counterpart identification tool.Comment: MNRAS, Paper accepted for publication. Updated catalogs are available at www.mpe.mpg.de/XraySurveys/2RXS_XMMSL2 . NWAY available at https://github.com/JohannesBuchner/nwa

Psychostimulant Drug Abuse and Personality Factors in Medical Students

Purpose: This study was designed to examine the prevalence of psychostimulant drug abuse among medical students and to test the hypothesis that medical students who use psychostimulant drugs for non-medical reasons are characterized by a sensation seeking and aggressive-hostility personality and exhibit lower empathy

Spin pseudogap in Ni-doped SrCuO2

The S=1/2 spin chain material SrCuO2 doped with 1% S=1 Ni-impurities is studied by inelastic neutron scattering. At low temperatures, the spectrum shows a pseudogap \Delta ~ 8 meV, absent in the parent compound, and not related to any structural phase transition. The pseudogap is shown to be a generic feature of quantum spin chains with dilute defects. A simple model based on this idea quantitatively accounts for the exprimental data measured in the temperature range 2-300 K, and allows to represent the momentum-integrated dynamic structure factor in a universal scaling form.Comment: 5 pages, 3 figure

Impact of 5-HT3 receptor antagonists on chemotherapy-induced nausea and vomiting: a retrospective cohort study

BACKGROUND: 1(st) generation 5-hydroxytryptamine receptor antagonists (5-HT(3) RAs), and palonosetron, a 2(nd) generation 5-HT(3) RA, are indicated for the prevention of chemotherapy (CT)-induced nausea and vomiting (CINV) associated with moderately (MEC) and highly emetogenic CT agents (HEC). This study explores the impact of step therapy policies requiring use of an older 5-HT(3) RA before palonosetron on risk of CINV associated with hospital or emergency department (ED) admissions. METHODS: Patients who received cyclophosphamide post breast cancer (BC) surgery or who were diagnosed with lung cancer on carboplatin (LC-carboplatin) or cisplatin (LC-cisplatin) were selected from PharMetrics’ (IMS LifeLink) claims dataset (2005-2008). Patients were followed for 6 months from initial CT administration for CINV events identified through ICD-9-CM codes. Patients were grouped into those initiated with older, generic 5-HT(3) RAs (ondansetron, granisetron, and dolasetron) and those initiated and maintained on palonosetron throughout study follow-up. CINV events and CINV days were analyzed using multivariate regressions controlling for demographic and clinical variables. RESULTS: Eligible patients numbered 3,606 in BC, 4,497 in LC-carboplatin and 1,154 in LC-cisplatin cohorts, with 52%, 40%, and 34% in the palonosetron group, respectively. There was no significant difference between the two 5-HT(3) RA groups in age or Charlson Comorbidity Index among the two MEC cohorts (BC and LC-carboplatin). Among the LC-cisplatin cohort, palonosetron users were older with more males than the older 5-HT(3) RA group (age: 60.1 vs. 61.3; males, 66.9% vs. 56.9%). Compared to the older 5-HT(3) RAs, the palonosetron groups incurred 22%-51% fewer 5-HT(3) RA pharmacy claims, had fewer patients with CINV events (3.5% vs. 5.5% in BC, 9.5% vs. 12.8% in LC-carboplatin, 16.4% vs. 21.7% in LC-cisplatin), and had lower risk for CINV events (odds ratios 0.62, 0.71, or 0.71, respectively; p < 0.05). The BC and LC-carboplatin palonosetron groups experienced 50% and 30% fewer CINV days than the generic 5-HT(3) RA group (p < 0.05). CONCLUSIONS: Patients with breast or lung cancer initiated and maintained on palonosetron were at significantly lower risk for potentially costly CINV versus those on older 5-HT(3) RAs. Further studies on impact of step therapy policy are warranted in order to minimize the clinical and economic burden of CINV

X-ray constraints on the fraction of obscured AGN at high accretion luminosities

The wide-area XMM-XXL X-ray survey is used to explore the fraction of obscured AGN at high accretion luminosities, $L_X (\rm 2-10 \, keV) > 10^{44} \, erg \,s ^{-1}$, and out to redshift $z\approx1.5$. The sample covers an area of about $\rm14\,deg^2$ and provides constraints on the space density of powerful AGN over a wide range of neutral hydrogen column densities extending beyond the Compton-thick limit, $\rm N_H\approx10^{24}\,cm^{-2}$. The fraction of obscured Compton-thin ($\rm N_H=10^{22}-10^{24}\,cm^{-2}$) AGN is estimated to be $\approx0.35$ for luminosities $L_X(\rm 2-10\,keV)>10^{44}\,erg\,s^{-1}$ independent of redshift. For less luminous sources the fraction of obscured Compton-thin AGN increases from $0.45\pm0.10$ at $z=0.25$ to $0.75\pm0.05$ at $z=1.25$. Studies that select AGN in the infrared via template fits to the observed Spectral Energy Distribution of extragalactic sources estimate space densities at high accretion luminosities consistent with the XMM-XXL constraints. There is no evidence for a large population of AGN (e.g. heavily obscured) identified in the infrared and missed at X-ray wavelengths. We further explore the mid-infrared colours of XMM-XXL AGN as a function of accretion luminosity, column density and redshift. The fraction of XMM-XXL sources that lie within the mid-infrared colour wedges defined in the literature to select AGN is primarily a function of redshift. This fraction increases from about 20-30% at z=0.25 to about 50-70% at $z=1.5$.Comment: MNRAS accepte

The X-ray luminosity function of Active Galactic Nuclei in the redshift interval z=3-5

We combine deep X-ray survey data from the Chandra observatory and the wide-area/shallow XMM-XXL field to estimate the AGN X-ray luminosity function in the redshift range z=3-5. The sample consists of nearly 340 sources with either photometric (212) or spectroscopic (128) redshift in the above range. The combination of deep and shallow survey fields provides a luminosity baseline of three orders of magnitude, Lx(2-10keV)~1e43-1e46erg/s at z>3. We follow a Bayesian approach to determine the binned AGN space density and explore their evolution in a model-independent way. Our methodology accounts for Poisson errors in the determination of X-ray fluxes and uncertainties in photometric redshift estimates. We demonstrate that the latter is essential for unbiased measurement of space densities. We find that the AGN X-ray luminosity function evolves strongly between the redshift intervals z=3-4 and z=4-5. There is also suggestive evidence that the amplitude of this evolution is luminosity dependent. The space density of AGN with Lx<1e45erg/s drops by a factor of 5 between the redshift intervals above, while the evolution of brighter AGN appears to be milder. Comparison of our X-ray luminosity function with that of UV/optical selected QSOs at similar redshifts shows broad agreement at bright luminosities, Lx>1e45erg/s. The faint-end slope of UV/optical luminosity functions however, is steeper than for X-ray selected AGN. This implies that the type-I AGN fraction increases with decreasing luminosity at z>3, opposite to trends established at lower redshift. We also assess the significance of AGN in keeping the hydrogen ionised at high redshift. Our X-ray luminosity function yields ionising photon rate densities that are insufficient to keep the Universe ionised at redshift z>4. A source of uncertainty in this calculation is the escape fraction of UV photons for X-ray selected AGN.Comment: MNRAS accepte

Instantaneous Normal Mode analysis of liquid HF

We present an Instantaneous Normal Modes analysis of liquid HF aimed to clarify the origin of peculiar dynamical properties which are supposed to stem from the arrangement of molecules in linear hydrogen-bonded network. The present study shows that this approach is an unique tool for the understanding of the spectral features revealed in the analysis of both single molecule and collective quantities. For the system under investigation we demonstrate the relevance of hydrogen-bonding ``stretching'' and fast librational motion in the interpretation of these features.Comment: REVTeX, 7 pages, 5 eps figures included. Minor changes in the text and in a figure. Accepted for publication in Phys. Rev. Let