17,646 research outputs found

    Usability of digital libraries

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    Health and cancer prevention: knowledge and beliefs of children and young people

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    Objective: To collect information from children and young people about their knowledge of and attitudes towards cancer and their understanding of health and health related behaviours to inform future health promotion work. Design: Questionnaire survey of 15-16 year olds, and interviews with play materials with 9-10 year old children. Setting: Six inner city, suburban, and rural schools. Subjects: 226 children aged 15-16 years and 100 aged 9-10 years. Main outcome measures: Knowledge about different types of cancer; beliefs about health; sources of information; quality of research data obtainable from young children about cancer and health. Results: Both samples knew most about lung cancer, but there was also some knowledge of breast and skin cancer and leukaemia. Smoking, together with pollution and other environmental factors, were seen as the dominant causes of cancer. Environmental factors were mentioned more often by the inner city samples. Television and the media were the most important sources of information. Young people were more worried about unemployment than about ill health. More than half the young people did not describe their health as good, and most said they did not have a healthy lifestyle. Children were able to provide detailed information about their knowledge and understanding by using drawings as well as interviews. Conclusions: Children and young people possess considerable knowledge about cancer, especially about lung cancer and smoking, and show considerable awareness of predominant health education messages. Despite this knowledge, many lead less than healthy lifestyles. Health is not seen as the most important goal in life by many young people; the circumstances in which many children and young people live are not experienced as health promoting

    The androgen receptor and signal-transduction pathways in hormone-refractory prostate cancer. Part 1: modifications to the androgen receptor

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    Prostate cancer is the second most common male malignancy in the western world an increasing incidence in an ageing population. Treatment of advanced prostate cancer relies on androgen deprivation. Although the majority of patients initially respond favourably to androgen deprivation therapy, the mean time to relapse is 12-18 months. Currently there are few treatments available for men who have developed resistance to hormone therapy, due to the lack of understanding of the molecular mechanisms underlying development of this disease. Recently, however, major advances have been made in understanding both androgen receptor (AR) dependent and independent pathways which promote development of hormone resistant prostate cancer. This review will focus on modifications to the AR and associated pathways. Molecular modifications to the androgen receptor itself, e.g. mutations and/or amplification, although involved in the development of hormone resistance cannot explain all cases. Phosphorylation of AR, via either Ras/MAP kinase or PI3K/Akt signal transduction pathways, have been shown to activate AR in both a ligand (androgen) dependent and independent fashion. During this review we will discuss the clinical evidence to support AR dependent pathways as mediators of hormone resistance

    TicQR: Flexible, Lightweight Linking of Paper and Digital Content Using Mobile Phones

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    In this paper we introduce TicQR - a photo-based checkbox-enabled interface which bridges the physical and digital document domains, allowing automatic download or processing of useful data from paper documents. There is a long demonstrated need for people to be able to connect between printed material and digital information and services. By using a combination of image recognition and QR codes we are able to detect user marks on paper documents via a single photograph taken with a standard smart phone. This information can then be used to access the equivalent digital content, save contacts or URLs, or even order goods directly from local retailers

    Fishes of the Red River in Arkansas

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    Fishes were collected from Red River mainstem habitats in Arkansas with seines, rotenone, hoop nets, gill nets, and trotlines from 1995 through 2001. Seventy-two species were identified distributed among 17 families, and 15 species were new records for the Red River in Arkansas. Eighty-three species are now historically known from the Arkansas segment of the Red River. Approximately 67% of the fishes known from the entire Red River have been found in the Arkansas segment, which is only 11% of the entire river length. Baseline data on the fish fauna of the Red River is critical for the analysis of potential effects to aquatic systems, and because of the potential for deleterious effects from alteration of aquatic habitats by a proposed project to extend the Red River Navigation System upstream from Shreveport, Louisiana to Index, Arkansas and by desalination projects upstream in Texas

    Depression, School Performance, and the Veridicality of Perceived Grades and Causal Attributions

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    An external criterion was assessed to test whether depressives have distorted perceptions of covariation information and whether their attributions are consistent with this information. Students’ actual and self-perceived grades, depression status, and attributions for failures were assessed. Furthermore, partici pants estimated average grades. Generally, self-perceived own past grades were inflated. Depressed students and those with low grades distorted their own grades (but not the average grade) more to their favor than individuals low in depression and those with high grades. Depression went along with lower actual grades and with internal, stable, and global failure attributions. Mood differences in attributions were not due to differences in previous grades. Depressed individuals drew (unrealistically) more depressogenic causal inferences when they perceived average grades to be low than when average grades were perceived to be high. However, they (realistically) attributed failure more in a depressogenic fashion than did nondepressives when their own grade history was low

    The Electronic and Superconducting Properties of Oxygen-Ordered MgB2 compounds of the form Mg2B3Ox

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    Possible candidates for the Mg2B3Ox nanostructures observed in bulk of polycrystalline MgB2 (Ref.1) have been studied using a combination of Z-contrast imaging, electron energy loss spectroscopy (EELS) and first-principles calculations. The electronic structures, phonon modes, and electron phonon coupling parameters are calculated for two oxygen-ordered MgB2 compounds of composition Mg2B3O and Mg2B3O2, and compared with those of MgB2. We find that the density of states for both Mg2B3Ox structures show very good agreement with EELS, indicating that they are excellent candidates to explain the observed coherent oxygen precipitates. Incorporation of oxygen reduces the transition temperature and gives calculated TC values of 18.3 K and 1.6 K for Mg2B3O and Mg2B3O2, respectively.Comment: Submitted to PR

    Testing the ΔS=ΔQ\Delta S=\Delta Q Rule with Exclusive Semi-Leptonic Kaon Decays

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    We consider the possibility of violations of the selection rule ΔS=ΔQ\Delta S=\Delta Q at an appreciable level in {\it exclusive} semi-leptonic decays of Kaons. At Φ\Phi-Factories, intense Kaon beams will be available and will probe among others, the semi-leptonic decays Kl4K_{l4} and Kl3γK_{l3\gamma} in addition to Kl3K_{l3} and could provide novel testing grounds for the ΔS=ΔQ\Delta S=\Delta Q rule. In particular, the branching ratio of Kl3γK_{l3\gamma} is non-negligible and could be used to probe new phenomena associated with the violation of this selection rule. Furthermore, we modify certain di-lepton event rate ratios and asymmetries and time asymmetries that have been constructed by Dass and Sarma for di-lepton events from Beon decays to test the ΔB=ΔQ\Delta B=\Delta Q at the Υ(4S)\Upsilon (4S), to the Kaon system at the ϕ(1020)\phi(1020). We find that the large width of the KSK_S relative to that of KLK_L plays an important role in enhancing some of the time asymmetries.Comment: 10 pages, Plain Latex, To be run twice

    WFPC2 LRF Imaging of Emission Line Nebulae in 3CR Radio Galaxies

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    We present HST/WFPC2 Linear Ramp Filter images of high surface brightness emission lines (either [OII], [OIII], or H-alpha+[NII]) in 80 3CR radio sources. We overlay the emission line images on high resolution VLA radio images (eight of which are new reductions of archival data) in order to examine the spatial relationship between the optical and radio emission. We confirm that the radio and optical emission line structures are consistent with weak alignment at low redshift (z < 0.6) except in the Compact Steep Spectrum (CSS) radio galaxies where both the radio source and the emission line nebulae are on galactic scales and strong alignment is seen at all redshifts. There are weak trends for the aligned emission line nebulae to be more luminous, and for the emission line nebula size to increase with redshift and/or radio power. The combination of these results suggests that there is a limited but real capacity for the radio source to influence the properties of the emission line nebulae at these low redshifts (z < 0.6). Our results are consistent with previous suggestions that both mechanical and radiant energy are responsible for generating alignment between the radio source and emission line gas.Comment: 80 pages, 54 figures. Accepted for publication in ApJ
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