199 research outputs found
Topology-aware indexing system for Urban Knowledge
Maps are being widely used as tools for presenting or retrieving information with spatial attributes. Existing map-based applications do not use the full potential of digital maps and geographical data: social media are disconnected from the underlying geographical entities; maps as visualization tools do not use the urban topology to cluster point of interest; maps as input systems are intrinsically ambiguous. This work presents a topology-aware indexing system supporting a new metaphor for a real integration between social media and digital maps. The methodology and technical solutions required to build and populate the indexing table starting from OpenStreetMap spatial primitives are introduced
Collaborative Multi-Perspective Urban Knowledge and Civic Media: A Never-Ending Design Challenge
Developing a civic social network requires to consider
users meeting in real life, collaborating on digital entries related
to real urban entities. This makes necessary to think about
collaboration tools in a new perspective: ensuring the
participation of users with different levels and forms of
legitimacy to represent complex relations among entities, and
ensuring the accountability of each contributor. We present a
set of technical solutions allowing the collaboration on complex
entities, keeping interactions simple, and representing multiple
perspectives about shared entities
Tracking azimuthons in nonlocal nonlinear media
We study the formation of azimuthons, i.e., rotating spatial solitons, in
media with nonlocal focusing nonlinearity. We show that whole families of these
solutions can be found by considering internal modes of classical non-rotating
stationary solutions, namely vortex solitons. This offers an exhaustive method
to identify azimuthons in a given nonlocal medium. We demonstrate formation of
azimuthons of different vorticities and explain their properties by considering
the strongly nonlocal limit of accessible solitons.Comment: 11 pages, 7 figure
Pediatric sinonasal neuroendocrine carcinoma following treatment for retinoblastoma. Human Pathology, 2009; 40:750-755.
Irisin, the novel myokine responsible for benefits of physical exercise on bone
It has been recently reported that, after physical exercise activity, the skeletal muscle releases Irisin, the newly identified myokine able of driving transition of white adipocytes into brown, following a phenomenon known as the browning response. This result suggested that skeletal muscle is crucial in the regulation of energy homeostasis, supporting its role as endocrine organ that targets adipose tissue by promoting energy expenditure. In accordance with this new finding, we demonstrated that conditioned media (CM) collected from primary myoblasts of exercised mice were able to induce osteoblast differentiation in a greater extent than those of mice housed in resting conditions and this effect is Irisin-mediated. In view of further proving the involvement of Irisin in bone metabolism, we validate its direct effect on osteoblasts by using r-Irisin. Here we show that phosphorylation of MAP kinase ERK and expression of Atf 4 (p<0,001), the key trascription factor of osteoblast differentiation, were significantly increased after Irisin treatment. Furthermore, ALP and pro-Collagen I mRNA resulted up regulated (p<0,001), as we already demonstrated by treating osteoblasts with conditioned medium from primary myoblasts of exercised mice. To recapitulate in vivo the effect of physical exercise, we injected mice with r-Irisin. Our results show that BV/TV of Irisin-treated mice was higher than vehicle-injected mice. In elderly, the severe decline of skeletal muscle function, known as Sarcopenia, is associated with impaired function of bone (Osteopenia) and these two simultaneous losses of function lead to increased risk of bone fractures. In order to reveal new strategies for treatment of sarcopenia and osteopenia, we also analyzed the effect of physical activity in old mice. Our findings demonstrate that mRNA levels of the most relevant bone proteins resulted up regulated in ex-vivo osteoblast obtained from exercised old mice compared with mice kept in resting conditions. Our data highlight a novel link in muscle-fat-bone axis demonstrating that Irisin targets bone tissue directly. Future perspectives, based on these studies, could satisfy the ongoing research of exercise-mimetic therapies with anabolic action on the skeleton
TNM staging and T-cell receptor gamma expression in colon adenocarcinoma. Correlation with disease progression?
Ultra-high-field targeted imaging of focal cortical dysplasia: The intracortical black line sign in type IIB
BACKGROUND AND PURPOSE: Conventional MR imaging has limitations in detecting focal cortical dysplasia. We assessed the added value of 7T in patients with histologically proved focal cortical dysplasia to highlight correlations between neuropathology and ultra-high-field imaging. MATERIALS AND METHODS: Between 2013 and 2019, we performed a standardized 7T MR imaging protocol in patients with drug-resistant focal epilepsy. We focused on 12 patients in whom postsurgical histopathology revealed focal cortical dysplasia and explored the diagnostic yield of preoperative 7T versus 1.5/3T MR imaging and the correlations of imaging findings with histopathology. We also assessed the relationship between epilepsy surgery outcome and the completeness of surgical removal of the MR imaging-visible structural abnormality. RESULTS: We observed clear abnormalities in 10/12 patients using 7T versus 9/12 revealed by 1.5/3T MR imaging. In patients with focal cortical dysplasia I, 7T MR imaging did not disclose morphologic abnormalities (n = 0/2). In patients with focal cortical dysplasia II, 7T uncovered morphologic signs that were not visible on clinical imaging in 1 patient with focal cortical dysplasia IIa (n = 1/4) and in all those with focal cortical dysplasia IIb (n = 6/6). T2*WI provided the highest added value, disclosing a peculiar intracortical hypointense band (black line) in 5/6 patients with focal cortical dysplasia IIb. The complete removal of the black line was associated with good postsurgical outcome (n = 4/5), while its incomplete removal yielded unsatisfactory results (n = 1/5). CONCLUSIONS: The high sensitivity of 7T T2*-weighted images provides an additional tool in defining potential morphologic markers of high epileptogenicity within the dysplastic tissue of focal cortical dysplasia IIb and will likely help to more precisely plan epilepsy surgery and explain surgical failures
NF2 gene expression in sporadic meningiomas: relation to grades or histotypes real time-pCR study.
NF2 expression levels of gastrointestinal stromal tumors: a quantitative real-time PCR study.
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