271 research outputs found
The incidence of all-cause, cardiovascular and respiratory disease admission among 20,252 users of lisinopril vs. perindopril: a cohort study
Background:
Major international guidelines do not offer explicit recommendations on any specific angiotensin-converting enzyme inhibitor (ACEI) agent over another within the same drug group. This study compared the effectiveness of lisinopril vs. perindopril in reducing the incidence of hospital admission due to all-cause, cardiovascular disease and respiratory disease.
Methods:
Adult patients who received new prescriptions of lisinopril or perindopril from 2001 to 2005 in all public hospitals and clinics in Hong Kong were included, and followed up for ≥2 years. The incidence of admissions due to all-cause, cardiovascular disease and respiratory disease were evaluated, respectively, by using Cox proportional hazard regression models. The regression models were constructed with propensity score matching to minimize indication biases.
Results:
A total of 20,252 eligible patients with an average age of 64.5 years (standard deviation 15.0) were included. The admission rate at 24 months within the date of index prescription due to any cause, cardiovascular disease and respiratory disease among lisinopril vs. perindopril users was 24.8% vs. 24.8%, 13.7% vs. 14.0% and 6.9% vs. 6.3%, respectively. Lisinopril users were significantly more likely to be admitted due to respiratory diseases (adjusted hazard ratios [AHR] = 1.25, 95% CI 1.08 to 1.43, p = 0.002 at 12 months; AHR = 1.17, 95% CI 1.04 to 1.31, p = 0.009 at 24 months) and all causes (AHR = 1.12, 95% CI 1.05 to 1.19, p < 0.001 at 24 months) than perindopril users.
Conclusions:
These findings support intra-class differences in the effectiveness of ACEIs, which could be considered by clinical guidelines when the preferred first-line antihypertensive drugs are recommended
Bailing Out the Milky Way: Variation in the Properties of Massive Dwarfs Among Galaxy-Sized Systems
Recent kinematical constraints on the internal densities of the Milky Way's
dwarf satellites have revealed a discrepancy with the subhalo populations of
simulated Galaxy-scale halos in the standard CDM model of hierarchical
structure formation. This has been dubbed the "too big to fail" problem, with
reference to the improbability of large and invisible companions existing in
the Galactic environment. In this paper, we argue that both the Milky Way
observations and simulated subhalos are consistent with the predictions of the
standard model for structure formation. Specifically, we show that there is
significant variation in the properties of subhalos among distinct host halos
of fixed mass and suggest that this can reasonably account for the deficit of
dense satellites in the Milky Way. We exploit well-tested analytic techniques
to predict the properties in a large sample of distinct host halos with a
variety of masses spanning the range expected of the Galactic halo. The
analytic model produces subhalo populations consistent with both Via Lactea II
and Aquarius, and our results suggest that natural variation in subhalo
properties suffices to explain the discrepancy between Milky Way satellite
kinematics and these numerical simulations. At least ~10% of Milky Way-sized
halos host subhalo populations for which there is no "too big to fail" problem,
even when the host halo mass is as large as M_host = 10^12.2 h^-1 M_sun.
Follow-up studies consisting of high-resolution simulations of a large number
of Milky Way-sized hosts are necessary to confirm our predictions. In the
absence of such efforts, the "too big to fail" problem does not appear to be a
significant challenge to the standard model of hierarchical formation.
[abridged]Comment: 12 pages, 3 figures; accepted by JCAP. Replaced with published
versio
Effect of halo modelling on WIMP exclusion limits
WIMP direct detection experiments are just reaching the sensitivity required
to detect galactic dark matter in the form of neutralinos. Data from these
experiments are usually analysed under the simplifying assumption that the
Milky Way halo is an isothermal sphere with maxwellian velocity distribution.
Observations and numerical simulations indicate that galaxy halos are in fact
triaxial and anisotropic. Furthermore, in the cold dark matter paradigm
galactic halos form via the merger of smaller subhalos, and at least some
residual substructure survives. We examine the effect of halo modelling on WIMP
exclusion limits, taking into account the detector response. Triaxial and
anisotropic halo models, with parameters motivated by observations and
numerical simulations, lead to significant changes which are different for
different experiments, while if the local WIMP distribution is dominated by
small scale clumps then the exclusion limits are changed dramatically.Comment: 9 pages, 9 figures, version to appear in Phys. Rev. D, minor change
Simulation techniques for cosmological simulations
Modern cosmological observations allow us to study in great detail the
evolution and history of the large scale structure hierarchy. The fundamental
problem of accurate constraints on the cosmological parameters, within a given
cosmological model, requires precise modelling of the observed structure. In
this paper we briefly review the current most effective techniques of large
scale structure simulations, emphasising both their advantages and
shortcomings. Starting with basics of the direct N-body simulations appropriate
to modelling cold dark matter evolution, we then discuss the direct-sum
technique GRAPE, particle-mesh (PM) and hybrid methods, combining the PM and
the tree algorithms. Simulations of baryonic matter in the Universe often use
hydrodynamic codes based on both particle methods that discretise mass, and
grid-based methods. We briefly describe Eulerian grid methods, and also some
variants of Lagrangian smoothed particle hydrodynamics (SPH) methods.Comment: 42 pages, 16 figures, accepted for publication in Space Science
Reviews, special issue "Clusters of galaxies: beyond the thermal view",
Editor J.S. Kaastra, Chapter 12; work done by an international team at the
International Space Science Institute (ISSI), Bern, organised by J.S.
Kaastra, A.M. Bykov, S. Schindler & J.A.M. Bleeke
The Physics of Cluster Mergers
Clusters of galaxies generally form by the gravitational merger of smaller
clusters and groups. Major cluster mergers are the most energetic events in the
Universe since the Big Bang. Some of the basic physical properties of mergers
will be discussed, with an emphasis on simple analytic arguments rather than
numerical simulations. Semi-analytic estimates of merger rates are reviewed,
and a simple treatment of the kinematics of binary mergers is given. Mergers
drive shocks into the intracluster medium, and these shocks heat the gas and
should also accelerate nonthermal relativistic particles. X-ray observations of
shocks can be used to determine the geometry and kinematics of the merger. Many
clusters contain cooling flow cores; the hydrodynamical interactions of these
cores with the hotter, less dense gas during mergers are discussed. As a result
of particle acceleration in shocks, clusters of galaxies should contain very
large populations of relativistic electrons and ions. Electrons with Lorentz
factors gamma~300 (energies E = gamma m_e c^2 ~ 150 MeV) are expected to be
particularly common. Observations and models for the radio, extreme
ultraviolet, hard X-ray, and gamma-ray emission from nonthermal particles
accelerated in these mergers are described.Comment: 38 pages with 9 embedded Postscript figures. To appear in Merging
Processes in Clusters of Galaxies, edited by L. Feretti, I. M. Gioia, and G.
Giovannini (Dordrecht: Kluwer), in press (2001
Inflation, cold dark matter, and the central density problem
A problem with high central densities in dark halos has arisen in the context
of LCDM cosmologies with scale-invariant initial power spectra. Although n=1 is
often justified by appealing to the inflation scenario, inflationary models
with mild deviations from scale-invariance are not uncommon and models with
significant running of the spectral index are plausible. Even mild deviations
from scale-invariance can be important because halo collapse times and
densities depend on the relative amount of small-scale power. We choose several
popular models of inflation and work out the ramifications for galaxy central
densities. For each model, we calculate its COBE-normalized power spectrum and
deduce the implied halo densities using a semi-analytic method calibrated
against N-body simulations. We compare our predictions to a sample of dark
matter-dominated galaxies using a non-parametric measure of the density. While
standard n=1, LCDM halos are overdense by a factor of 6, several of our example
inflation+CDM models predict halo densities well within the range preferred by
observations. We also show how the presence of massive (0.5 eV) neutrinos may
help to alleviate the central density problem even with n=1. We conclude that
galaxy central densities may not be as problematic for the CDM paradigm as is
sometimes assumed: rather than telling us something about the nature of the
dark matter, galaxy rotation curves may be telling us something about inflation
and/or neutrinos. An important test of this idea will be an eventual consensus
on the value of sigma_8, the rms overdensity on the scale 8 h^-1 Mpc. Our
successful models have values of sigma_8 approximately 0.75, which is within
the range of recent determinations. Finally, models with n>1 (or sigma_8 > 1)
are highly disfavored.Comment: 13 pages, 6 figures. Minor changes made to reflect referee's
Comments, error in Eq. (18) corrected, references updated and corrected,
conclusions unchanged. Version accepted for publication in Phys. Rev. D,
scheduled for 15 August 200
Observing the First Stars and Black Holes
The high sensitivity of JWST will open a new window on the end of the
cosmological dark ages. Small stellar clusters, with a stellar mass of several
10^6 M_sun, and low-mass black holes (BHs), with a mass of several 10^5 M_sun
should be directly detectable out to redshift z=10, and individual supernovae
(SNe) and gamma ray burst (GRB) afterglows are bright enough to be visible
beyond this redshift. Dense primordial gas, in the process of collapsing from
large scales to form protogalaxies, may also be possible to image through
diffuse recombination line emission, possibly even before stars or BHs are
formed. In this article, I discuss the key physical processes that are expected
to have determined the sizes of the first star-clusters and black holes, and
the prospect of studying these objects by direct detections with JWST and with
other instruments. The direct light emitted by the very first stellar clusters
and intermediate-mass black holes at z>10 will likely fall below JWST's
detection threshold. However, JWST could reveal a decline at the faint-end of
the high-redshift luminosity function, and thereby shed light on radiative and
other feedback effects that operate at these early epochs. JWST will also have
the sensitivity to detect individual SNe from beyond z=10. In a dedicated
survey lasting for several weeks, thousands of SNe could be detected at z>6,
with a redshift distribution extending to the formation of the very first stars
at z>15. Using these SNe as tracers may be the only method to map out the
earliest stages of the cosmic star-formation history. Finally, we point out
that studying the earliest objects at high redshift will also offer a new
window on the primordial power spectrum, on 100 times smaller scales than
probed by current large-scale structure data.Comment: Invited contribution to "Astrophysics in the Next Decade: JWST and
Concurrent Facilities", Astrophysics & Space Science Library, Eds. H.
Thronson, A. Tielens, M. Stiavelli, Springer: Dordrecht (2008
The PHENIX Experiment at RHIC
The physics emphases of the PHENIX collaboration and the design and current
status of the PHENIX detector are discussed. The plan of the collaboration for
making the most effective use of the available luminosity in the first years of
RHIC operation is also presented.Comment: 5 pages, 1 figure. Further details of the PHENIX physics program
available at http://www.rhic.bnl.gov/phenix
On the spin distributions of CDM haloes
We used merger trees realizations, predicted by the extended Press-Schechter
theory, in order to study the growth of angular momentum of dark matter haloes.
Our results showed that: 1) The spin parameter resulting from the
above method, is an increasing function of the present day mass of the halo.
The mean value of varies from 0.0343 to 0.0484 for haloes with
present day masses in the range of to
. 2)The distribution of is close to
a log-normal, but, as it is already found in the results of N-body simulations,
the match is not satisfactory at the tails of the distribution. A new
analytical formula that approximates the results much more satisfactorily is
presented. 3) The distribution of the values of depends only weakly
on the redshift. 4) The spin parameter of an halo depends on the number of
recent major mergers. Specifically the spin parameter is an increasing function
of this number.Comment: 10 pages, 8 figure
Baryons: What, When and Where?
We review the current state of empirical knowledge of the total budget of
baryonic matter in the Universe as observed since the epoch of reionization.
Our summary examines on three milestone redshifts since the reionization of H
in the IGM, z = 3, 1, and 0, with emphasis on the endpoints. We review the
observational techniques used to discover and characterize the phases of
baryons. In the spirit of the meeting, the level is aimed at a diverse and
non-expert audience and additional attention is given to describe how space
missions expected to launch within the next decade will impact this scientific
field.Comment: Proceedings Review for "Astrophysics in the Next Decade: JWST and
Concurrent Facilities", ed. X. Tielens, 38 pages, 10 color figures. Revised
to address comments from the communit
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