3,411 research outputs found
On the evolution of young radio-loud AGN
This paper describes an investigation of the early evolution of extragalactic
radio sources using samples of faint and bright Gigahertz Peaked Spectrum (GPS)
and Compact Steep Spectrum (CSS) radio galaxies. Correlations found between
their peak frequency, peak flux density and angular size provide strong
evidence that synchrotron self absorption is the cause of the spectral
turnovers, and indicate that young radio sources evolve in a self-similar way.
In addition, the data seem to suggest that the sources are in equipartition
while they evolve. If GPS sources evolve to large size radio sources, their
redshift dependent birth-functions should be the same. Therefore, since the
lifetimes of radio sources are thought to be short compared to the Hubble time,
the observed difference in redshift distribution between GPS and large size
sources must be due to a difference in slope of their luminosity functions. We
argue that this slope is strongly affected by the luminosity evolution of the
individual sources. A scenario for the luminosity evolution is proposed in
which GPS sources increase in luminosity and large scale radio sources decrease
in luminosity with time. This evolution scenario is expected for a ram-pressure
confined radio source in a surrounding medium with a King profile density. In
the inner parts of the King profile, the density of the medium is constant and
the radio source builds up its luminosity, but after it grows large enough the
density of th e surrounding medium declines and the luminosity of the radio
source decreases. A comparison of the local luminosity function (LLF) of GPS
galaxies with that of extended sources is a good test for this evolution
scenario [abridged].Comment: LaTeX, 11 pages, 8 figures; Accepted by MNRAS. Related papers may be
found at http://www.ast.cam.ac.uk/~snellen . Valuable comments of referee
incorporated. More discussion on simulation
The LOFAR Magnetism Key Science Project
Measuring radio waves at low frequencies offers a new window to study cosmic
magnetism, and LOFAR is the ideal radio telescope to open this window widely.
The LOFAR Magnetism Key Science Project (MKSP) draws together expertise from
multiple fields of magnetism science and intends to use LOFAR to tackle
fundamental questions on cosmic magnetism by exploiting a variety of
observational techniques. Surveys will provide diffuse emission from the Milky
Way and from nearby galaxies, tracking the propagation of long-lived cosmic-ray
electrons through magnetic field structures, to search for radio halos around
spiral and dwarf galaxies and for magnetic fields in intergalactic space.
Targeted deep-field observations of selected nearby galaxies and suspected
intergalactic filaments allow sensitive mapping of weak magnetic fields through
Rotation Measure (RM) grids. High-resolution observations of protostellar jets
and giant radio galaxies reveal structures on small physical scales and at high
redshifts, whilst pulsar RMs map large-scale magnetic structures of the
Galactic disk and halo in revolutionary detail. The MKSP is responsible for the
development of polarization calibration and processing, thus widening the
scientific power of LOFAR.Comment: Proceedings of "Magnetic Fields in the Universe: From Laboratory and
Stars to Primordial Structures", 2011 Aug. 21-27 in Zakopane/Poland, eds. M.
Soida et a
How does a cadaver model work for testing ultrasound diagnostic capability for rheumatic-like tendon damage?
To establish whether a cadaver model can serve as an effective surrogate for the detection of tendon damage characteristic of rheumatoid arthritis (RA). In addition, we evaluated intraobserver and interobserver agreement in the grading of RA-like tendon tears shown by US, as well as the concordance between the US findings and the surgically induced lesions in the cadaver model. RA-like tendon damage was surgically induced in the tibialis anterior tendon (TAT) and tibialis posterior tendon (TPT) of ten ankle/foot fresh-frozen cadaveric specimens. Of the 20 tendons examined, six were randomly assigned a surgically induced partial tear; six a complete tear; and eight left undamaged. Three rheumatologists, experts in musculoskeletal US, assessed from 1 to 5 the quality of US imaging of the cadaveric models on a Likert scale. Tendons were then categorized as having either no damage, (0); partial tear, (1); or complete tear (2). All 20 tendons were blindly and independently evaluated twice, over two rounds, by each of the three observers. Overall, technical performance was satisfactory for all items in the two rounds (all values over 2.9 in a Likert scale 1-5). Intraobserver and interobserver agreement for US grading of tendon damage was good (mean Îș values 0.62 and 0.71, respectively), with greater reliability found in the TAT than the TPT. Concordance between US findings and experimental tendon lesions was acceptable (70-100 %), again greater for the TAT than for the TPT. A cadaver model with surgically created tendon damage can be useful in evaluating US metric properties of RA tendon lesions
Reliability Exercise for the Polymyalgia Rheumatica Classification Criteria Study: The Oranjewoud Ultrasound Substudy
Objective. A study supported by the EULAR and the ACR being conducted to establish classification criteria for polymyalgia rheumatica (PMR) will include ultrasound examination of the shoulders and hips. Ultrasound (US) depicts glenohumeral joint effusion, biceps tenosynovitis, subdeltoid bursitis, hip joint synovitis, and trochanteric bursitis in PMR. These findings may aid in distinguishing PMR from other diseases. The purpose of this study was to assess standards and US interreader agreement of participants in the PMR classification criteria study.
Methods. Sixteen physicians in four groups examined shoulders and hips of 4 patients and 4 healthy adults with ultrasound. Overall agreement and interobserver agreement were calculated. Results. The overall agreement (OA) between groups was 87%. The OA for healthy shoulders was 88.8%, for healthy hips 100%, for shoulders with pathology 85.2%, and 74.3% for hips with pathology, respectively. Conclusion. There was a high degree of agreement found for the examination of healthy shoulders and pathologic hips. Agreement was moderate for pathologic shoulders and perfect for healthy hips. US of shoulder and hips performed by different examiners is a reliable and feasible tool for assessment of PMR related disease pathology and can be incorporated into a classification criteria study
Alendronate or alfacalcidol in glucocorticoid-induced osteoporosis
BACKGROUND: Treatment with glucocorticoids is associated with bone loss starting soon after therapy is initiated and an increased risk of fracture. METHODS: We performed a randomized, double-placebo, double-blind clinical trial of 18 months' duration among patients with a rheumatic disease who were starting glucocorticoids at a daily dose that was equivalent to at least 7.5 mg of prednisone. A total of 201 patients were assigned to receive either alendronate (10 mg) and a placebo capsule of alfacalcidol daily or alfacalcidol (1 mu g) and a placebo tablet of alendronate daily. The primary outcome was the change in bone mineral density of the lumbar spine in 18 months; the secondary outcome was the incidence of morphometric vertebral deformities. RESULTS: A total of 100 patients received alendronate, and 101 received alfacalcidol; 163 patients completed the study. The bone mineral density of the lumbar spine increased by 2.1 percent in the alendronate group (95 percent confidence interval, 1.1 to 3.1 percent) and decreased by 1.9 percent in the alfacalcidol group (95 percent confidence interval, -3.1 to -0.7 percent). At 18 months, the mean difference of change in bone mineral density between the two groups was 4.0 percent (95 percent confidence interval, 2.4 to 5.5 percent). Three patients in the alendronate group had a new vertebral deformity, as compared with eight patients in the alfacalcidol group (of whom three had symptomatic vertebral fractures) (hazard ratio, 0.4; 95 percent confidence interval, 0.1 to 1.4). CONCLUSIONS: During this 18-month trial in patients with rheumatic diseases, alendronate was more effective in the prevention of glucocorticoid-induced bone loss than was alfacalcidol
Uveal Melanoma Patients Have a Distinct Metabolic Phenotype in Peripheral Blood
Uveal melanomas (UM) are detected earlier. Consequently, tumors are smaller, allowing for novel eye-preserving treatments. This reduces tumor tissue available for genomic profiling. Additionally, these small tumors can be hard to differentiate from nevi, creating the need for minimally invasive detection and prognostication. Metabolites show promise as minimally invasive detection by resembling the biological phenotype. In this pilot study, we determined metabolite patterns in the peripheral blood of UM patients (n = 113) and controls (n = 46) using untargeted metabolomics. Using a random forest classifier (RFC) and leave-one-out cross-validation, we confirmed discriminatory metabolite patterns in UM patients compared to controls with an area under the curve of the receiver operating characteristic of 0.99 in both positive and negative ion modes. The RFC and leave-one-out cross-validation did not reveal discriminatory metabolite patterns in high-risk versus low-risk of metastasizing in UM patients. Ten-time repeated analyses of the RFC and LOOCV using 50% randomly distributed samples showed similar results for UM patients versus controls and prognostic groups. Pathway analysis using annotated metabolites indicated dysregulation of several processes associated with malignancies. Consequently, minimally invasive metabolomics could potentially allow for screening as it distinguishes metabolite patterns that are putatively associated with oncogenic processes in the peripheral blood plasma of UM patients from controls at the time of diagnosis.</p
A very brief description of LOFAR - the Low Frequency Array
LOFAR (Low Frequency Array) is an innovative radio telescope optimized for
the frequency range 30-240 MHz. The telescope is realized as a phased aperture
array without any moving parts. Digital beam forming allows the telescope to
point to any part of the sky within a second. Transient buffering makes
retrospective imaging of explosive short-term events possible. The scientific
focus of LOFAR will initially be on four key science projects (KSPs): 1)
detection of the formation of the very first stars and galaxies in the universe
during the so-called epoch of reionization by measuring the power spectrum of
the neutral hydrogen 21-cm line (Shaver et al. 1999) on the ~5' scale; 2)
low-frequency surveys of the sky with of order expected new sources; 3)
all-sky monitoring and detection of transient radio sources such as gamma-ray
bursts, x-ray binaries, and exo-planets (Farrell et al. 2004); and 4) radio
detection of ultra-high energy cosmic rays and neutrinos (Falcke & Gorham 2003)
allowing for the first time access to particles beyond 10^21 eV (Scholten et
al. 2006). Apart from the KSPs open access for smaller projects is also
planned. Here we give a brief description of the telescope.Comment: 2 pages, IAU GA 2006, Highlights of Astronomy, Volume 14, K.A. van
der Hucht, e
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