Exploración con biomicroscopio ocular : Técnicas y protocolo de intervención

Exploración con biomicroscopio ocular es un libro que puede ser utilizado desde los primeros semestres en los programas de Óptica y Optometría, por su manera clara y sencilla de explicar cada una de las partes del segmento anterior y las diferentes técnicas de iluminación a través del examen de biomicroscopía, entendiendo que éste examen es uno de los más importantes y necesarios para el manejo adecuado de la salud visual y ocular de nuestros pacientes. Es por ello que el libro inicia en su primer capítulo con el tema del “Rol social y profesional del contactólogo”, explicando el porqué debemos como profesionales de la salud visual capacitarnos y prepararnos para hacer de manera adecuada la atención primaria en salud visual. Continúa explicando las técnicas de iluminación paso por paso de manera sencilla y detallada, permitiendo de una manera clara y específica que el lector entienda el cómo utilizarlas de manera adecuada. Los demás capítulos profundizan en la descripción anatómica, fisiológica y patológica de las estructuras del segmento anterior. (del prólogo de Margarita María Ayala Cárdenas)Facultad de Ciencias Exacta

Building a rheumatology biobank for reliable basic/translational research and precision medicine

Research biobanks are non-profit structures that collect, manipulate, store, analyze and distribute systematically organized biological samples and data for research and development purposes. Over the recent years, we have established a biobank, the Rheumatology BioBank (RheumaBank) headed by the Medicine and Rheumatology unit of the IRCCS Istituto Ortopedico Rizzoli (IOR) in Bologna, Italy for the purpose of collecting, processing, storing, and distributing biological samples and associated data obtained from patients suffering from inflammatory joint diseases. RheumaBank is a research biobank, and its main objective is to promote large-scale, high-quality basic, translational, and clinical research studies that can help elucidate pathogenetic mechanisms and improve personalization of treatment choice in patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA) and other spondyloarthritides (SpA)

Post-Acute COVID-19 Joint Pain and New Onset of Rheumatic Musculoskeletal Diseases: A Systematic Review

As the number of reports of post-acute COVID-19 musculoskeletal manifestations is rapidly rising, it is important to summarize the current available literature in order to shed light on this new and not fully understood phenomenon. Therefore, we conducted a systematic review to provide an updated picture of post-acute COVID-19 musculoskeletal manifestations of potential rheumatological interest, with a particular focus on joint pain, new onset of rheumatic musculoskeletal diseases and presence of autoantibodies related to inflammatory arthritis such as rheumatoid factor and anti-citrullinated protein antibodies. We included 54 original papers in our systematic review. The prevalence of arthralgia was found to range from 2% to 65% within a time frame varying from 4 weeks to 12 months after acute SARS-CoV-2 infection. Inflammatory arthritis was also reported with various clinical phenotypes such as symmetrical polyarthritis with RA-like pattern similar to other prototypical viral arthritis, polymyalgia-like symptoms, or acute monoarthritis and oligoarthritis of large joints resembling reactive arthritis. Moreover, high figures of post-COVID-19 patients fulfilling the classification criteria for fibromyalgia were found, ranging from 31% to 40%. Finally, the available literature about prevalence of rheumatoid factor and anti-citrullinated protein antibodies was largely inconsistent. In conclusion, manifestations of rheumatological interest such as joint pain, new-onset inflammatory arthritis and fibromyalgia are frequently reported after COVID-19, highlighting the potential role of SARS-CoV-2 as a trigger for the development of autoimmune conditions and rheumatic musculoskeletal diseases

Covid-19 vaccine hesitancy in systemic sclerosis

Non

Aportaciones al conocimiento de la evolución paleoclimática y paleoambiental en la Península Ibérica durante los dos ultimos millones de años a partir del estudio de trasvertinos y espeleotemas

En este trabajo se contemplan los resultados principales del Proyecto" Reconstrucción Paleoclimática desde el Pleistoceno Medio a partir de análisis geocronológicos e isotópicos de travertinos españoles" (P. CEC FI2W-CT91-0075 " Paleoclimatological revision of climate evolution in the Western Mediterranean Region, Evaluation of altered scenarios) . Se seleccionaron cuatro áreas de depósitos travertínicos de carácter fluvial (Priego, Río Blanco), lacustre (Río Blanco, Banyoles) y aluvial (Tolox) así como una zona con depósitos espeleotémicos (Karst de la Cueva del Reguerillo). En ellas se obtuvieron datos sobre la evolución del paisaje y del clima, los travertinos y espeleotemas son indicadores de clima cálido s.l. que de forma abreviada son: O Mediante la geomorfología y dataciones (paleomagnetismo, U/Th, Resonancia de espín Resumen electrónico y racemización de aminoácidos), se determinó las historia fluvial de los travertinos de Priego y Río Blanco así como del Karst de la Cueva del Reguerillo donde, además, se dataron un paleosismo y fenómenos de neotectónica. La data más antigua obtenida mediante Resonancia de espín electrónico fue 950ka, mientras que mediante racemización de aminoácidos se dataron depósitos de más de 750ka. Mediante dataciones, sedimentología, análisis de isótopos estables y palinología se determinaron aspectos de la evolución climática de algunas áreas de la Península Ibérica. La correlación entre palinología e isotopía permitió la validación de algunos de los resultados. También se obtuvieron datos cualitativos sobre input hidraúlicos a los sistemas fluviales o kársticos

POS1246 COVID-19 IN ITALIAN PATIENTS WITH RHEUMATIC AUTOIMMUNE SYSTEMIC DISEASES: RESULTS OF A NATIONWIDE SURVEY STUDY

Background: SARS-CoV-2 infection poses a serious challenge for patients with rheumatic autoimmune systemic diseases (ASD), characterized by marked immune-system dysregulation and frequent visceral organ involvement. Objectives: To evaluate the impact of Covid-19 pandemic in a large series of Italian patients with ASD. Methods: Our multicenter telephone survey (8-week period, March-April 2020) included a large series of 2,994 patients (584 M, 2,410 F, mean age 58.9±13.4SD years) with ASD followed at 34 tertiary referral centers of 14 regions of northern, central, and southern Italian macro areas, characterized by different prevalence of SARS-CoV-2 infection. According to currently used criteria, Covid-19 was classified as definite Covid-19 (signs or symptoms of Covid-19 confirmed by positive oral/nasopharyngeal swabs at PCR testing) or highly suspected Covid-19 (signs or symptoms highly

New findings in osteoarthritis pathogenesis: therapeutic implications.

This review focuses on the new perspectives which can provide insight into the crucial pathways that drive cartilage-bone physiopathology. In particular, we discuss the critical signaling and effector molecules that can activate cellular and molecular processes in both cartilage and bone cells and which may be relevant in cross talk among joint compartments: growth factors (bone morphogenetic proteins and transforming growth factor), hypoxia-related factors, cell-matrix interactions [discoidin domain receptor 2 (DDR2) and syndecan 4], signaling molecules [WNT, Hedgehog (Hh)]. With the continuous progression of our knowledge on the molecular pathways involved in cartilage and bone changes in osteoarthritis (OA), an increasing number of potentially effective candidates for OA therapy are already under scrutiny in clinical trials to ascertain their possible safe use in an attempt to identify molecules active in slowing or halting OA progression and reducing joint pain. We then review the principal molecules currently under clinical investigation