HISTORICAL AND ARCHAEOSEISMIC STUDIES IN THE POLLINO AREA

Section 1. Reappraisal of the January 8, 1693 Pollino earthquake Section 2. Archaeoseismic field survey Section 3. Investigation of damaged speleothem

Preditores de comportamentos de autocuidado em indivíduos com insuficiência cardíaca no Brasil

Objetivo: Identificar preditores de comportamentos de autocuidado em indivíduos com insuficiência cardíaca no Brasil.Método: Estudo transversal com 405 pacientes com insuficiência cardíaca. Os comportamentos de autocuidado foram analisados através do Self-Careof Heart Failure Index (Índice de Autocuidado na Insuficiência Cardíaca). Características clínicas e sociodemográficas foram investigadas como preditores da manutenção do autocuidado, de sua administração, e da confiança, por meio de regressões logísticas. Resultados: Os preditores da manutenção do autocuidado foram o número de filhos (p<0.01), a fração de ejeção do ventrículo esquerdo (p<0.01), sentimentos positivos sobre a doença (p=0.03), obesidade (p=0.02), e doença renal dialítica crônica (p<0.01). Os preditores de administração do autocuidado foram ter filhos casados (p<0.01) e apneia (p<0.01). Os preditores de confiança no autocuidado foram renda familiar (p<0.01), número de internações nos 12 meses anteriores (p=0.01), número de doses de medicação diárias (p<0.01), e sedentarismo (p<0.01).Conclusão: Encontrou-se alguns preditores associados aos comportamentos de autocuidado, de modo que educação intensiva e auxílio social deveriam ser oferecidos aos pacientes com essas características.Descritores: Insuficiência cardíaca. Autocuidado. Autogestão. Comportamento relacionados com a saúde. Enfermage

TITLE: Looking for surface faulting ancestors of the L’Aquila April 6, 2009 event: preliminary paleoseismological data and seismic hazard implications

The occurrence of the Mw 6.3, April 6, 2009 earthquake has highlighted how critical is the knowledge of the location and of the characteristics of the active faults in a seismic region. This is true not only as a contribution to the seismic hazard assessment but also for the local planning of residential areas, plants and infrastructures. The 2009 earthquake occurred on the Paganica normal fault (PF hereinafter) and produced 3 km-long, maximum 0.1 m-high surface rupture along its central section, and secondary slip along nearby tectonic structures. The PF consists of a prominent morphologic scarp formed by the tectonic juxtaposition of Pliocene-middle Pleistocene and late Pleistocene alluvial deposits, and by lower scarps in late Pleistocene-Holocene deposits. The fault, NW-SE striking and SW dipping, runs for a total length of about 20 km along the NE side of the Aterno River valley, a graben-type basin bounded by marked antithetic faults. The limited extent and the small throw of the 2009 surface ruptures, when compared to the size of the Paganica long-term fault scarp, suggest that the PF probably experienced larger Magnitude earthquakes than the 2009 seismic event. Thus, although the April 6, 2009 earthquake and associated surface faulting caused loss of lives and major damage, we believe that this event does not fully characterize the seismic hazard of the area. Therefore, a campaign of paleoseismological investigations is underway with the aim of defining the Max Magnitude, the average rate of displacement and the frequency of seismic events on the PF and on the nearby faults. An amazing “coseismic” trench, caved by the overpressure produced by the broken pipe of an aqueduct, provided the exposure of a 30-m wide fault zone of the PF. We show the preliminary results from the analysis of this site, as well as from other sites along the PF. In addition, we also present preliminary paleoseismological data from the antithetic Fossa fault. A major finding at this early stage of our field campaign is the recognition of large displacements (0.5 to 1 m) associated to individual events affecting deposits of Holocene age based on radiocarbon dating and pottery content

The liquefaction features in the area of the May-June 2012 Emilia seismic sequence: An investigation approach coupling Electric Resistivity Tomography (ERT) with coring

In order to geometrically characterize the liquefaction features observed in the epicentral sector of the 2012 Emilia seismic sequence and to evaluate the potential for recording palaeoseismic features of the area, we performed two electric resistivity tomographic sections and 4 shallow corings, coupled with 14C datings and archaeological age estimates in selected sites. Preliminary results show that there is a good agreement between ERT sections and core-logs; moreover a major role in determining the scalar relationships of the liquefaction features is played by the local geomorphological and topographic setting. The high sedimentation rates obtained through core datings (4 – 20 mm/yr) suggest that the described methodological approach can cover time windows of only a few centuries, thus hardly encompassing, in this tectonic setting, a significant period for paleoseismological purposes.Published206-2092T. Deformazione crostale attivaN/A or not JC

Evidence for surface faulting earthquakes on the Montereale fault system (Abruzzi Apennines, central Italy)

We conducted paleoseismic studies along the Montereale fault system (MFS; central Italy). The MFS shows geomorphological evidence of Late Quaternary activity and falls within the highest seismic hazard zone of central Apennines, between the epicentral areas of two recent earthquake sequences: 2009 L’Aquila and 2016–2017 central Italy. We excavated two trenches along the San Giovanni fault splay of the system, one intercepting the N140° striking bedrock main fault plane and the other cutting two subparallel fault scarps on the colluvial/alluvial deposits on the fault hanging wall. Excavations revealed repeated fault reactivation with surface faulting in prehistorical and historical times. We recognized and dated seven events in the last 26 kyr. The most recent ground-rupturing event (evb1) possibly occurred 650–1,820 AD, consistent with one of the three main shocks that struck the area in 1,703 AD. A previous event (evb2) occurred between 5,330 BC and 730 BC, while older events occurred at 6,590–5,440 BC (evb3), 9,770–6,630 BC (evb4), and 16,860–13,480 BC (evb5). We documented two older displacement events (evb7 and evb6) between 23,780 BC and 16,850 BC. The minimum vertical slip rate at the trench site in the last 28–24 kyr is 0.3–0.4 mm/year. The inferred average recurrence interval for surface-faulting events along the MFS is no longer than ~4 kyr. Based on the surface fault length ranging between 12 and 20 km, earthquakes with ≥M 6.0 are possible for the MFS. The MFS is an independent earthquake source, and its paleoseismic data are fully comparable with those known for faults in central Apennines.Published2758-27766T. Studi di pericolosità sismica e da maremotoJCR Journa

Laryngopharyngeal reflux diagnosis in obstructive sleep apnea patients using the pepsin salivary test

Background: To investigate the presence of laryngopharyngeal reflux in patients with obstructive sleep apnea (OSA) employing the salivary pepsin concentration method. To compare the results of pepsin concentration with the severity of the pathology. Methods: Seventy-five OSA patients (44 males, 31 females) were enrolled in the study. For each patient, the AHI (apnea–hypopnea index) and the BMI (body mass index) were initially evaluated. All the patients enrolled were assessed using the reflux symptom index (RSI) and the reflux finding score (RFS) in order to perform a clinical diagnosis of laryngopharyngeal reflux. In all patients a salivary sample was taken to estimate the presence of pepsin and its concentration. Results: The incidence of LPR (laryngopharyngeal reflux) in OSA patients, evaluated using the salivary pepsin concentration test (PEP-test), was found to be 32% of cases. Linear regression testing did not show any correlation between AHI and pepsin concentration in salivary samples (p = 0.1). Conclusion: A high number of patients with OSA seem to show positivity for salivary pepsin, correlated to an LPR. There does not appear to be a correlation between the severity of apnea and the grade of salivary pepsin reflux. On the other hand, direct correlation between BMI and the value of pepsin in salivary specimens was observed

What is the future for agroforestry in Italy?

The successful promotion of agroforestry in Italy depends on both a recognition of tradition and the opportunities for innovation. In Italy, agroforestry has traditionally been a key component of landscape management. Complex systems, based on the integration among crops–livestock–fruit/forest trees, provided a wide variety of products (e.g. food, feed, fibers, fuelwood and timber) and other ecosystem services (e.g. soil erosion control and biodiversity preservation). Silvopastoral systems have been used for centuries and are still managed in marginal areas. The integration of fruits trees (in primis olive trees) with crops and grazing was widely practiced and is still profitable. Coltura promiscua was historically developed integrating fruit and forest trees and particularly multifunctional trees (e.g. Juglans regia L. and Prunus avium L.) to support vines and intercrops. Building on recent research, projects have also focused on innovation in agroforestry. The adoption of shade tolerant forage species and crops has been studied in silvopastoral and olive systems. Silvopastoral systems can significantly offset the greenhouse gas emissions produced by livestock and shield grazing animals from “heat waves”. Integration of fast growing timber trees (like Populus) in arable systems can help reverse the decline in plantation forestry in Italy. Finally, the constraints imposed by the EU agricultural policy, especially the prevalent provisions for monocrops severely limiting the introduction of innovative agroforestry approaches, are discussed. New political measures and certification actions are strongly required

Surface ruptures database related to the 26 December 2018, MW 4.9 Mt. Etna earthquake, southern Italy

We provide a database of the surface ruptures produced by the 26 December 2018 Mw 4.9 earthquake that struck the eastern flank of Mt. Etna volcano in Sicily (southern Italy). Despite its relatively small magnitude, this shallow earthquake caused about 8 km of surface faulting, along the trace of the NNW-trending active Fiandaca Fault. Detailed field surveys have been performed in the epicentral area to map the ruptures and to characterize their kinematics. The surface ruptures show a dominant right-oblique sense of displacement with an average slip of about 0.09 m and a maximum value of 0.35 m. We have parsed and organized all observations in a concise database, with 932 homogeneous georeferenced records. The Fiandaca Fault is part of the complex active Timpe faults system affecting the eastern flank of Etna, and its seismic history indicates a prominent surface-faulting potential. Therefore, this database is essential for unravelling the seismotectonics of shallow earthquakes in volcanic areas, and contributes updating empirical scaling regressions that relate magnitude and extent of surface faulting.Publishedid 422T. Deformazione crostale attivaJCR Journa

Surface ruptures following the 26 December 2018, Mw 4.9, Mt. Etna earthquake, Sicily (Italy)

We present a 1:10,000 scale map of the coseismic surface ruptures following the 26 December 2018 Mw 4.9 earthquake that struck the eastern flank of Mt. Etna volcano (southern Italy). Detailed rupture mapping is based on extensive field surveys in the epicentral region. Despite the small size of the event, we were able to document surface faulting for about 8 km along the trace of the NNW-trending active Fiandaca Fault, belonging to the Timpe tectonic system in the eastern flank of the volcano. The mapped ruptures are characterized in most cases by perceivable opening and by a dominant right-oblique sense of slip, with an average slip of about 0.09 m and a peak value of 0.35 m. It is also noteworthy that the ruptures vary significantly in their kinematic expression, denoting locally high degree of complexity of the surface faulting.Published831-8372T. Deformazione crostale attivaJCR Journa

Short-course combination treatment for experimental chronic Chagas disease

Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, affects millions of people in the Americas and across the world, leading to considerable morbidity and mortality. Current treatment options, benznidazole (BNZ) and nifurtimox, offer limited efficacy and often lead to adverse side effects because of long treatment durations. Better treatment options are therefore urgently required. Here, we describe a pyrrolopyrimidine series, identified through phenotypic screening, that offers an opportunity to improve on current treatments. In vitro cell-based washout assays demonstrate that compounds in the series are incapable of killing all parasites; however, combining these pyrrolopyrimidines with a subefficacious dose of BNZ can clear all parasites in vitro after 5 days. These findings were replicated in a clinically predictive in vivo model of chronic Chagas disease, where 5 days of treatment with the combination was sufficient to prevent parasite relapse. Comprehensive mechanism of action studies, supported by ligand-structure modeling, show that compounds from this pyrrolopyrimidine series inhibit the Qi active site of T. cruzi cytochrome b, part of the cytochrome bc1 complex of the electron transport chain. Knowledge of the molecular target enabled a cascade of assays to be assembled to evaluate selectivity over the human cytochrome b homolog. As a result, a highly selective and efficacious lead compound was identified. The combination of our lead compound with BNZ rapidly clears T. cruzi parasites, both in vitro and in vivo, and shows great potential to overcome key issues associated with currently available treatments.</p