Gades and the Mediterranean: a Process of Integration

The impetus for this paper is to present possible contributions of the Network Theory approach to the analysis of the Roman presence in Turdetania by the end of the 1st millennium BC. Firstly, we discuss how some written sources, such as Strabo’s Geography, describe this region and how the countryside and coastal areas are mentioned. Secondly, we present how contemporary historiography makes use of Network Theory to investigate numerous issues of Ancient History. Finally, we point out a proposal for Social Network Analysis (SNA) to questions regarding Turdetania before and after Roman occupation

Nitric Oxide Regulates Neurogenesis in the Hippocampus following Seizures

Hippocampal neurogenesis is changed by brain injury. When neuroinflammation accompanies injury, activation of resident microglial cells promotes the release of inflammatory cytokines and reactive oxygen/nitrogen species like nitric oxide (NO). In these conditions, NO promotes proliferation of neural stem cells (NSC) in the hippocampus. However, little is known about the role of NO in the survival and differentiation of newborn cells in the injured dentate gyrus. Here we investigated the role of NO following seizures in the regulation of proliferation, migration, differentiation, and survival of NSC in the hippocampus using the kainic acid (KA) induced seizuremouse model. We show that NO increased the proliferation of NSC and the number of neuroblasts following seizures but was detrimental to the survival of newborn neurons. NO was also required for the maintenance of long-term neuroinflammation. Taken together, our data show that NO positively contributes to the initial stages of neurogenesis following seizures but compromises survival of newborn neurons.Foundation for Science and Technology (FCT, Portugal); COMPETE; FEDER [PTDC/SAU-NEU/102612/2008, PTDC/NEU-OSD/0473/2012, PEst-C/SAU/LA0001/2013-2014, PEst-OE/EQB/LA0023/2013-2014]; FCT, Portugal [SFRH/BPD/78901/2011, SFRH/BD/77903/2011

Sensorimotor coordination and metastability in a situated HKB model

Oscillatory phenomena are ubiquitous in nature and have become particularly relevant for the study of brain and behaviour. One of the simplest, yet explanatorily powerful, models of oscillatory Coordination Dynamics is the Haken–Kelso–Bunz (HKB) model. The metastable regime described by the HKB equation has been hypothesised to be the signature of brain oscillatory dynamics underlying sensorimotor coordination. Despite evidence supporting such a hypothesis, to our knowledge, there are still very few models (if any) where the HKB equation generates spatially situated behaviour and, at the same time, has its dynamics modulated by the behaviour it generates (by means of the sensory feedback resulting from body movement). This work presents a computational model where the HKB equation controls an agent performing a simple gradient climbing task and shows (i) how different metastable dynamical patterns in the HKB equation are generated and sustained by the continuous interaction between the agent and its environment; and (ii) how the emergence of functional metastable patterns in the HKB equation – i.e. patterns that generate gradient climbing behaviour – depends not only on the structure of the agent's sensory input but also on the coordinated coupling of the agent's motor–sensory dynamics. This work contributes to Kelso's theoretical framework and also to the understanding of neural oscillations and sensorimotor coordination

BNDES, industrial policies and Brazilian regional dynamics in the 21st century

Fil: Santos, Leandro Bruno. Universidad Fluminense de Brasi