28,903 research outputs found
Anopheline salivary protein genes and gene families: an evolutionary overview after the whole genome sequence of sixteen Anopheles species
Background: Mosquito saliva is a complex cocktail whose pharmacological properties play an essential role in
blood feeding by counteracting host physiological response to tissue injury. Moreover, vector borne pathogens are
transmitted to vertebrates and exposed to their immune system in the context of mosquito saliva which, in virtue
of its immunomodulatory properties, can modify the local environment at the feeding site and eventually affect
pathogen transmission. In addition, the host antibody response to salivary proteins may be used to assess human
exposure to mosquito vectors. Even though the role of quite a few mosquito salivary proteins has been clarified in
the last decade, we still completely ignore the physiological role of many of them as well as the extent of their
involvement in the complex interactions taking place between the mosquito vectors, the pathogens they transmit
and the vertebrate host. The recent release of the genomes of 16 Anopheles species offered the opportunity to get
insights into function and evolution of salivary protein families in anopheline mosquitoes.
Results: Orthologues of fifty three Anopheles gambiae salivary proteins were retrieved and annotated from 18
additional anopheline species belonging to the three subgenera Cellia, Anopheles, and Nyssorhynchus. Our analysis
included 824 full-length salivary proteins from 24 different families and allowed the identification of 79 novel
salivary genes and re-annotation of 379 wrong predictions. The comparative, structural and phylogenetic analyses
yielded an unprecedented view of the anopheline salivary repertoires and of their evolution over 100 million years
of anopheline radiation shedding light on mechanisms and evolutionary forces that contributed shaping the
anopheline sialomes.
Conclusions: We provide here a comprehensive description, classification and evolutionary overview of the main
anopheline salivary protein families and identify two novel candidate markers of human exposure to malaria vectors
worldwide. This anopheline sialome catalogue, which is easily accessible as hyperlinked spreadsheet, is expected to
be useful to the vector biology community and to improve the capacity to gain a deeper understanding of
mosquito salivary proteins facilitating their possible exploitation for epidemiological and/or pathogen-vector-host
interaction studies
Theory of interlayer exchange interactions in magnetic multilayers
This paper presents a review of the phenomenon of interlayer exchange
coupling in magnetic multilayers. The emphasis is put on a pedagogical
presentation of the mechanism of the phenomenon, which has been successfully
explained in terms of a spin-dependent quantum confinement effect. The
theoretical predictions are discussed in connection with corresponding
experimental investigations.Comment: 18 pages, 4 PS figures, LaTeX with IOP package; v2: ref. added.
Further (p)reprints available from http://www.mpi-halle.de/~theory
Charge Distributions in Metallic Alloys: a Charge Excess Functional theory approach
Charge Distributions in Metallic Alloys: a Charge Excess Functional theory
approachComment: 13 pages, 5 figure
Pose consensus based on dual quaternion algebra with application to decentralized formation control of mobile manipulators
This paper presents a solution based on dual quaternion algebra to the
general problem of pose (i.e., position and orientation) consensus for systems
composed of multiple rigid-bodies. The dual quaternion algebra is used to model
the agents' poses and also in the distributed control laws, making the proposed
technique easily applicable to time-varying formation control of general
robotic systems. The proposed pose consensus protocol has guaranteed
convergence when the interaction among the agents is represented by directed
graphs with directed spanning trees, which is a more general result when
compared to the literature on formation control. In order to illustrate the
proposed pose consensus protocol and its extension to the problem of formation
control, we present a numerical simulation with a large number of free-flying
agents and also an application of cooperative manipulation by using real mobile
manipulators
Anomalous Hall Effect due to the spin chirality in the Kagom\'{e} lattice
We consider a model for a two dimensional electron gas moving on a kagom\'{e}
lattice and locally coupled to a chiral magnetic texture. We show that the
transverse conductivity does not vanish even if spin-orbit
coupling is not present and it may exhibit unusual behavior. Model parameters
are the chirality, the number of conduction electrons and the amplitude of the
local coupling. Upon varying these parameters, a topological transition
characterized by change of the band Chern numbers occur. As a consequence,
can be quantized, proportional to the chirality or have a non
monotonic behavior upon varying these parameters.Comment: 8 pages, 7 figure
General method for extracting the quantum efficiency of dispersive qubit readout in circuit QED
We present and demonstrate a general three-step method for extracting the
quantum efficiency of dispersive qubit readout in circuit QED. We use active
depletion of post-measurement photons and optimal integration weight functions
on two quadratures to maximize the signal-to-noise ratio of the
non-steady-state homodyne measurement. We derive analytically and demonstrate
experimentally that the method robustly extracts the quantum efficiency for
arbitrary readout conditions in the linear regime. We use the proven method to
optimally bias a Josephson traveling-wave parametric amplifier and to quantify
different noise contributions in the readout amplification chain.Comment: 10 pages, 6 figure
Topological Hall effect and Berry phase in magnetic nanostructures
We discuss the anomalous Hall effect in a two-dimensional electron gas
subject to a spatially varying magnetization. This topological Hall effect
(THE) does not require any spin-orbit coupling, and arises solely from Berry
phase acquired by an electron moving in a smoothly varying magnetization. We
propose an experiment with a structure containing 2D electrons or holes of
diluted magnetic semiconductor subject to the stray field of a lattice of
magnetic nanocylinders. The striking behavior predicted for such a system (of
which all relevant parameters are well known) allows to observe unambiguously
the THE and to distinguish it from other mechanisms.Comment: 5 pages with 4 figure
The aging male: investigation, treatment and monitoring of late-onset hypogonadism in males
Androgen deficiency in the aging male has become a topic of increasing interest and debate throughout the world. The demographics clearly demonstrate the increasing percentage of the population that is in the older age groups. The data also support the concept that testosterone falls progressively with age and that a significant percentage of men over the age of 60 years have serum testosterone levels that are below the lower limits of young adults (age 20-30 years) men. The principal questions raised by these observations are whether older hypogonadal men will benefit from testosterone treatment and what will be the risks associated with such intervention. The past decade has brought evidence of benefit of androgen treatment on multiple target organs of hypogonadal men and recent studies show short-term beneficial effects of testosterone in older men that are similar to those in younger men. Long-term data on the effects of testosterone treatment in the older population are limited and specific risk data on the prostate and cardiovascular systems are needed. Answers to key questions of functional benefits that may retard frailty of the elderly are not yet available. The recommendations described below were prepared for the International Society of Andrology (ISA) and the International Society for the Study of the Aging Male (ISSAM) following a panel discussion with active participation from the audience sponsored by the ISA on the topic at the 4th ISSAM Congress in Prague in February 2004.peer-reviewe
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