EXPLICIT STRONG SOLUTIONS OF MULTIDIMENSIONAL STOCHASTIC DIFFERENTIAL EQUATIONS

Herein, we characterize strong solutions of multidimensional stochastic differential equations (formula) that can be represented locally as (formula) where W is an multidimensional Brownian motion and U, (symbole) are continuous functions. Assuming that (symbole) is continuously differentiable, we find that (symbole) must satisfy a commutation relation for such explicit solutions to exist and we identify all drift terms b as well as U and (symbole) that will allow X to be represented in this manner. Our method is based on the existence of a local change of coordinates in terms of a diffeomorphism between the solutions X and the strong solutions to a simpler Ito integral equation.Diffeomorphism, Ito processes, explicit solutions.

Arthrodendron borberensis sp. nov., a large protist (Foraminifera) from the Pagliaro Formation (Paleocene), Northern Apennines, Italy

Arthrodendron borberensis sp. nov. is described from the Pagliaro Formation (Paleocene) of the Northern Apennines. Specimens of the new species are preserved on the sole of a turbiditic sandstone bed. Arthrodendron borberensis sp. nov. is characterized by its long chambers (some exceeding 10 mm in length), its generally straight course, and rare branching at an acute angle. This large foraminifer lived infaunally within the sediment and possibly as epifauna after exhumation by erosion, prior to the deposition of the host turbiditic sandstone bed. Assemblages of smaller agglutinated foraminifera (a flysch-type fauna) and trace fossils (Nereites ichnofacies) point to a deep-sea environment for the discussed protist

Predicting cancer drug mechanisms of action using molecular network signatures

Molecular signatures are a powerful approach to characterize novel small molecules and derivatized small molecule libraries. While new experimental techniques are being developed in diverse model systems, informatics approaches lag behind these exciting advances. We propose an analysis pipeline for signature based drug annotation. We develop an integrated strategy, utilizing supervised and unsupervised learning methodologies that are bridged by network based statistics. Using this approach we can: 1, predict new examples of drug mechanisms that we trained our model upon; 2, identify “New” mechanisms of action that do not belong to drug categories that our model was trained upon; and 3, update our training sets with these “New” mechanisms and accurately predict entirely distinct examples from these new categories. Thus, not only does our strategy provide statistical generalization but it also offers biological generalization. Additionally, we show that our approach is applicable to diverse types of data, and that distinct biological mechanisms characterize its resolution of categories across different data types. As particular examples, we find that our predictive resolution of drug mechanisms from mRNA expression studies relies upon the analog measurement of a cell stress-related transcriptional rheostat along with a transcriptional representation of cell cycle state; whereas, in contrast, drug mechanism resolution from functional RNAi studies rely upon more dichotomous (e.g., either enhances or inhibits) association with cell death states. We believe that our approach can facilitate molecular signature-based drug mechanism understanding from different technology platforms and across diverse biological phenomena.National Cancer Institute (U.S.) (NCI Integrative Cancer Biology Program grant U54-CA112967

Immigration Legislation and Issues in the 114th Congress

The House and the Senate have considered immigration measures on a variety of issues in the 114th Congress. The Consolidated Appropriations Act, 2016 (P.L. 114-113) extends four immigration programs through September 30, 2016: the EB-5 immigrant investor Regional Center Pilot Program, the E-Verify employment eligibility verification system, the Conrad State program for foreign medical graduates, and the special immigrant religious worker program. P.L. 114-113 also contains provisions on the Visa Waiver Program and certain nonimmigrant visa categories. Other enacted immigration-related measures include the Border Jobs for Veterans Act of 2015 (P.L. 114-68) on border security personnel, the Adoptive Family Relief Act (P.L. 114-70) on intercountry adoption, and the National Defense Authorization Act for Fiscal Year 2016 (P.L. 114-92) on the Afghan special immigrant visa program. The House has passed several other immigration-related bills. Among them are the Northern Border Security Review Act (H.R. 455), the Preclearance Authorization Act of 2015 (H.R. 998), the Border Security Technology Accountability Act of 2015 (H.R. 1634), the Enforce the Law for Sanctuary Cities Act (H.R. 3009), and the American SAFE Act of 2015 (H.R. 4038). H.R. 998 has also been reported by the Senate Homeland Security and Governmental Affairs Committee with an amendment in the nature of a substitute. In addition, various bills on border security, interior enforcement, visa security, and asylum, among other issues, have been considered by a House or Senate committee. Border security- related measures have been reported or ordered to be reported by the House Homeland Security Committee (H.R. 399, H.R. 3583, H.R. 3586), or the Senate Homeland Security and Governmental Affairs Committee (S. 750, S. 1808, S. 1864,S. 1873). Interior enforcement provisions are included in bills ordered to be reported by the House Judiciary Committee (H.R. 1147, H.R. 1148, H.R. 1153) or reported by the House Appropriations Committee (H.R. 3128). S. 1635, as reported by the Senate Foreign Relations Committee, also contains interior enforcement- related provisions. Several of these interior enforcement bills also contain key provisions on other immigration issues. Among the other issues addressed in these bills are employment eligibility verification (H.R. 1147); visa security and naturalization (H.R. 1148); and expedited removal, asylum, parole, and unaccompanied alien children (H.R. 1153). H.R. 1149, as ordered to be reported by the House Judiciary Committee, also addresses unaccompanied alien children. This report discusses these and other immigration-related issues that have received legislative action or are of significant congressional interest in the 114th Congress. Department of Homeland Security appropriations are addressed in CRS Report R44053, Department of Homeland Security Appropriations: FY2016, and, for the most part, are not covered here

Multistage Zeeman deceleration of metastable neon

A supersonic beam of metastable neon atoms has been decelerated by exploiting the interaction between the magnetic moment of the atoms and time-dependent inhomogeneous magnetic fields in a multistage Zeeman decelerator. Using 91 deceleration solenoids, the atoms were decelerated from an initial velocity of 580m/s to final velocities as low as 105m/s, corresponding to a removal of more than 95% of their initial kinetic energy. The phase-space distribution of the cold, decelerated atoms was characterized by time-of-flight and imaging measurements, from which a temperature of 10mK was obtained in the moving frame of the decelerated sample. In combination with particle-trajectory simulations, these measurements allowed the phase-space acceptance of the decelerator to be quantified. The degree of isotope separation that can be achieved by multistage Zeeman deceleration was also studied by performing experiments with pulse sequences generated for $^{20}$Ne and $^{22}$Ne.Comment: 16 pages, 15 figure

Goodness-of-fit tests for complete spatial randomness based on Minkowski functionals of binary images

We propose a class of goodness-of-fit tests for complete spatial randomness (CSR). In contrast to standard tests, our procedure utilizes a transformation of the data to a binary image, which is then characterized by geometric functionals. Under a suitable limiting regime, we derive the asymptotic distribution of the test statistics under the null hypothesis and almost sure limits under certain alternatives. The new tests are computationally efficient, and simulations show that they are strong competitors to other tests of CSR. The tests are applied to a real data set in gamma-ray astronomy, and immediate extensions are presented to encourage further work

Large astrorhizid foraminifera from Oligocene - Lower Miocene deep-sea sediments, Northern Apennines, Italy : a new perspective on the genus Astrorhizinoides Stschedrina, 1969

Nulliporites bombicoides Sacco, 1888 and Nulliporites stellaris Sacco, 1888 from the Oligocene - Lower Miocene deep-sea turbiditic sediments of Liguria and Piedmont (Monastero and Rocchetta formations) appear to belarge, agglutinated astrorhizid foraminiferids both assigned in this study tothe genus Astrorhizinoides Stschedrina, 1969 under a single species, Astrorhizinoides bombicoides (Sacco, 1888). This foraminiferis characterized by a simple, straight to slightly curved or rarely branched test, which displays a thick, smooth, finely agglutinated wall, with constrictions, and a very thin chamber lumen, whose apertures are observed at least at one of the terminal ends of the test. The tests, partly crushed, are preserved mostly on the soles of thin turbiditic sandstones, where they may be aligned. Probably, the foraminifer was originally a semi-infaunal, free-standing form, the test of which was partly flexible

Versatile in vivo regulation of tumor phenotypes by dCas9-mediated transcriptional perturbation

Targeted transcriptional regulation is a powerful tool to study genetic mediators of cellular behavior. Here, we show that catalytically dead Cas9 (dCas9) targeted to genomic regions upstream or downstream of the transcription start site allows for specific and sustainable gene-expression level alterations in tumor cells in vitro and in syngeneic immune-competent mouse models. We used this approach for a high-coverage pooled gene-activation screen in vivo and discovered previously unidentified modulators of tumor growth and therapeutic response. Moreover, by using dCas9 linked to an activation domain, we can either enhance or suppress target gene expression simply by changing the genetic location of dCas9 binding relative to the transcription start site. We demonstrate that these directed changes in gene-transcription levels occur with minimal off-target effects. Our findings highlight the use of dCas9-mediated transcriptional regulation as a versatile tool to reproducibly interrogate tumor phenotypes in vivo. Keywords: cancer genetics; cancer models; cancer therapeutic resistance; gene regulation; CRISPRNational Cancer Institute (U.S.) (Grant U54-CA112967-06)National Cancer Institute (U.S.) (Grant P30-CA14051

Autonomous Light Management in Flexible Photoelectrochromic Films Integrating High Performance Silicon Solar Microcells

Commercial smart window technologies for dynamic light and heat management in building and automotive environments traditionally rely on electrochromic (EC) materials powered by an external source. This design complicates building-scale installation requirements and substantially increases costs for applications in retrofit construction. Self-powered photoelectrochromic (PEC) windows are an intuitive alternative wherein a photovoltaic (PV) material is used to power the electrochromic device, which modulates the transmission of the incident solar flux. The PV component in this application must be sufficiently transparent and produce enough power to efficiently modulate the EC device transmission. Here, we propose Si solar microcells (μ-cells) that are i) small enough to be visually transparent to the eye, and ii) thin enough to enable flexible PEC devices. Visual transparency is achieved when Si μ-cells are arranged in high pitch (i.e. low-integration density) form factors while maintaining the advantages of a single-crystalline PV material (i.e., long lifetime and high performance). Additionally, the thin dimensions of these Si μ-cells enable fabrication on flexible substrates to realize these flexible PEC devices. The current work demonstrates this concept using WO₃ as the EC material and V₂O₅ as the ion storage layer, where each component is fabricated via sol-gel methods that afford improved prospects for scalability and tunability in comparison to thermal evaporation methods. The EC devices display fast switching times, as low as 8 seconds, with a modulation in transmission as high as 33%. Integration with two Si μ-cells in series (affording a 1.12 V output) demonstrates an integrated PEC module design with switching times of less than 3 minutes, and a modulation in transmission of 32% with an unprecedented EC:PV areal ratio